Search Results - "Mitchell, D Y"

Effect of renal function on risedronate pharmacokinetics after a single oral dose by Mitchell, D. Y., St. Peter, J. V., Eusebio, R.A., Pallone, K. A., Kelly, S. C., Russell, D. A., Nesbitt, J. D., Thompson, G. A., Powell, J. H.

“…Aims  To determine the relationship between risedronate pharmacokinetics and renal function. Methods  Risedronate was administered to adult men and women…”
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The effect of dosing regimen on the pharmacokinetics of risedronate by MITCHELL, D. Y, HEISE, M. A, PALLONE, K. A, CLAY, M. E, NESBITT, J. D, RUSSELL, D. A, MELSON, C. W

“…Aims To examine the effect of timing of a risedronate dose relative to food intake on the rate and extent of risedronate absorption following single‐dose, oral…”
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Dose-Proportional Pharmacokinetics of Risedronate on Single-Dose Oral Administration to Healthy Volunteers by Mitchell, David Y., Eusebio, Rachelle A., Sacco-Gibson, Nancy A., Pallone, Karen A., Kelly, Sandra C., Nesbitt, John D., Brezovic, Christopher P, Thompson, Gary A., Powefl, James H.

“…Risedronate is a pyridinyl bisphosphonate approved for the treatment of Paget's disease (US‐FDA) and in development for the treatment and prevention of…”
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Risedronate pharmacokinetics and intra- and inter-subject variability upon single-dose intravenous and oral administration by MITCHELL, David Y, BARR, William H, EUSEBIO, Rachelle A, STEVENS, Karen A, DUKE, Frank P, RUSSELL, Darrell A, NESBITT, John D, POWELL, James H, THOMPSON, Gary A

“…To determine the pharmacokinetics and absolute bioavailability of risedronate after single-dose oral administration of 30 mg risedronate as a tablet and an…”
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Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole:  Prodrugs for the Enolic OH Group by Robinson, Ralph P, Reiter, Lawrence A, Barth, Wayne E, Campeta, Anthony M, Cooper, Kelvin, Cronin, Brian J, Destito, Rosalina, Donahue, Kathleen M, Falkner, Fred C, Fiese, Eugene F, Johnson, Diane L, Kuperman, Alexander V, Liston, Theodore E, Malloy, Deborah, Martin, John J, Mitchell, David Y, Rusek, Frank W, Shamblin, Sheri L, Wright, Charles F

“…Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and screened as potential prodrugs of 1. This effort led to the discovery…”
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Risedronate gastrointestinal absorption is independent of site and rate of administration by MITCHELL, D. Y, EUSEBIO, R. A, DUNLAP, L. E, PALLONE, K. A, NESBITT, J. D, RUSSELL, D. A, CLAY, M. E, BEKKER, P. J

“…Two studies were conducted to compare the absorption of risedronate administered as a solution to three different gastrointestinal sites (study A) and to…”
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Relationship between age, renal function and bone mineral density in the US population by KLAWANSKY, Sidney, KOMAROFF, Eugene, CAVANAUGH, Paul F, MITCHELL, David Y, GORDON, Matthew J, CONNELLY, Janet E, ROSS, Susan D

“…Bisphosphonate drugs for treating osteoporosis are excreted by the kidney. However, many of the major trials on efficacy and safety of the bisphophonates for…”
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Metabolism of the glutathione-acrolein adduct, S-(2-aldehydo-ethyl)glutathione, by rat liver alcohol and aldehyde dehydrogenase by Mitchell, D Y, Petersen, D R

“…The oxidative and reductive metabolism of the acrolein-glutathione adduct, S-(2,aldehydo-ethyl)glutathione, by rat liver aldehyde dehydrogenase (ALDH) and…”
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Inhibition of rat liver aldehyde dehydrogenases by acrolein by Mitchell, D Y, Petersen, D R

“…Acrolein, the lowest member of the ethylenic aldehyde series, has been widely studied as a result of the diverse toxicities associated with it. Previous…”
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Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase-mediated acetaldehyde oxidation by trans-4-hydroxy-2-nonenal by Mitchell, D Y, Petersen, D R

“…The hepatic oxidation of ethanol has been demonstrated to cause peroxidation of cellular membranes, resulting in the production of aldehydes that are…”
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The oxidation of alpha-beta unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases by Mitchell, D Y, Petersen, D R

“…Lipid peroxidation of microsomal membranes produces a large number of aldehydes, alcohols, and ketones, of which some are cytotoxic. trans-4-Hydroxy-2-nonenal…”
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Inhibition of rat liver mitochondrial and cytosolic aldehyde dehydrogenases by crotonaldehyde by Mitchell, D Y, Petersen, D R

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Effect of P-450 inducers on biliary excretion of glutathione and its hydrolysis products. Correlation between hepatic gamma-glutamyltranspeptidase activity and the proportion of glutathione hydrolysis products in bile by Madhu, C, Mitchell, D Y, Klaassen, C D

“…This study was designed to determine if a relationship exists between hepatic gamma-glutamyltranspeptidase (gamma-GT) activity and the biliary excretion of…”
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Oxidation of aldehydic products of lipid peroxidation by rat liver microsomal aldehyde dehydrogenase by Mitchell, D Y, Petersen, D R

“…Lipid peroxidation in microsomal membranes produces a large number of aldehydes, alcohols, and ketones, some of which have been shown to be cytotoxic. This…”
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Simultaneous determination of tenidap and its stable isotope analog in serum by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry by Avery, M J, Mitchell, D Y, Falkner, F C, Fouda, H G

“…A specific high-performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for the quantitative determination…”
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Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer by RINEHART, John, ADJEI, Alex A, GULYAS, Stephen, MITCHELL, David Y, HERRERA, Roman, SEBOLT-LEOPOLD, Judith S, MEYER, Mark B, LORUSSO, Patricia M, WATERHOUSE, David, HECHT, J. Randolph, NATALE, Ronald B, HAMID, Oday, VARTERASIAN, Mary, ASBURY, Peggy, KALDJIAN, Eric P

“…This multicenter, open-label, phase II study was undertaken to assess the antitumor activity and safety of the oral mitogen-activated extracellular signal…”
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Phase I and Pharmacodynamic Study of the Oral MEK Inhibitor CI-1040 in Patients With Advanced Malignancies by Lorusso, Patricia M, Adjei, Alex A, Varterasian, Mary, Gadgeel, Shirish, Reid, Joel, Mitchell, David Y, Hanson, Lorelei, DeLuca, Pamela, Bruzek, Laura, Piens, Jill, Asbury, Peggy, Van Becelaere, Keri, Herrera, Roman, Sebolt-Leopold, Judith, Meyer, Mark B

“…This phase I study was undertaken to define the toxicity, pharmacokinetics, pharmacodynamics, maximum tolerated dose (MTD), and clinical activity of CI-1040, a…”
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Aldehydic products of lipid peroxidation: substrates or inhibitors of hepatic aldehyde dehydrogenase? by Petersen, D R, Hjelle, J J, Mitchell, D Y

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Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis by Griffiths, R J, Pettipher, E R, Koch, K, Farrell, C A, Breslow, R, Conklyn, M J, Smith, M A, Hackman, B C, Wimberly, D J, Milici, A J

“…Leukotriene B4 (LTB4) is a product of the 5-lipoxygenase pathway of arachidonic acid metabolism. LTB4 is a potent chemotactic factor for neutrophils and has…”
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Evaluation of the pharmacodynamic and pharmacokinetic interaction between pagoclone and ethanol by Haig, G. M., Giordani, B., Randinitis, E. J., Mitchell, D. Y.

“…Clinical Pharmacology & Therapeutics (2003) 73, P93–P93; doi:…”
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