Search Results - "Mitchell, Aaron C."

Engineering growth factors for regenerative medicine applications by Mitchell, Aaron C., Briquez, Priscilla S., Hubbell, Jeffrey A., Cochran, Jennifer R.

“…[Display omitted] Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their…”
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A novel protein‐engineered hepatocyte growth factor analog released via a shear‐thinning injectable hydrogel enhances post‐infarction ventricular function by Steele, Amanda N., Cai, Lei, Truong, Vi N., Edwards, Bryan B., Goldstone, Andrew B., Eskandari, Anahita, Mitchell, Aaron C., Marquardt, Laura M., Foster, Abbygail A., Cochran, Jennifer R., Heilshorn, Sarah C., Woo, Y. Joseph

“…ABSTRACT In the last decade, numerous growth factors and biomaterials have been explored for the treatment of myocardial infarction (MI). While pre‐clinical…”
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Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein by Mitchell, Aaron C., Kannan, Deepti, Hunter, Sean A., Parra Sperberg, R. Andres, Chang, Cheryl H., Cochran, Jennifer R.

“…Dysregulated matriptase activity has been established as a key contributor to cancer progression through its activation of growth factors, including the…”
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Development of a Protease Biosensor Based on a Dimerization-Dependent Red Fluorescent Protein by Mitchell, Aaron C, Alford, Spencer C, Hunter, Sean A, Kannan, Deepti, Parra Sperberg, R. Andres, Chang, Cheryl H, Cochran, Jennifer R

“…Dysregulated activity of the protease matriptase is a key contributor to aggressive tumor growth, cancer metastasis, and osteoarthritis. Methods for the…”
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Degradable Acetalated Dextran Microparticles for Tunable Release of an Engineered Hepatocyte Growth Factor Fragment by Suarez, Sophia L, Muñoz, Adam, Mitchell, Aaron C, Braden, Rebecca L, Luo, Colin, Cochran, Jennifer R, Almutairi, Adah, Christman, Karen L

“…Injectable biomaterials are promising as new therapies to treat myocardial infarction (MI). One useful property of biomaterials is the ability to protect and…”
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Abstract 20275: A Novel Engineered Hepatocyte Growth Factor Analog Released via a Temperature-Responsive, Shear-Thinning Hydrogel Enhances Post-Infarction Ventricular Function by Steele, Amanda N, Cai, Lei, Goldstone, Andrew B, Edwards, Bryan B, Mitchell, Aaron C, Eskandari, Anahita, Stapleton, Lyndsay M, Kawamura, Masashi, Patel, Jay, Hopkins, Michael, Cochran, Jennifer R, Heilshorn, Sarah C, Woo, Y Joseph

“…ObjectiveHepatocyte growth factor is cardioprotective, anti-apoptotic, and pro-angiogenic; yet, is limited in clinical translation due to its high…”
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