Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents

We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively...

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Bibliographic Details
Published in:	Biomaterials science Vol. 5; no. 3; p. 432
Main Authors:	Sivakumar, Balasubramanian, Aswathy, Ravindran Girija, Romero-Aburto, Rebeca, Mitcham, Trevor, Mitchel, Keith A, Nagaoka, Yutaka, Bouchard, Richard R, Ajayan, Pulickel M, Maekawa, Toru, Sakthikumar, Dasappan Nair
Format:	Journal Article
Language:	English
Published:	England 01-03-2017
Subjects:	Aptamers, Nucleotide - chemistry Cell Line, Tumor Contrast Media - chemistry Drug Carriers - chemistry Drug Delivery Systems - methods Humans Lactic Acid - chemistry Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Multimodal Imaging - methods Nanocomposites - chemistry Neoplasms - diagnostic imaging Optical Imaging - methods Photoacoustic Techniques - methods Polyglycolic Acid - chemistry
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Summary:	We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics. The hyperthermic ability of these nanocomposites was mediated by SPIONs upon NIR-laser irradiation. In vitro cytotoxicity was shown by curcumin-loaded nanoparticles as well as the photothermal ablation of cancer cells mediated by the drug-encapsulated nanocomposite demonstrated the potential therapeutic effect of the nanocomposite. In short, we portray the aptamer-conjugated nanocomposite as a multimodal material capable of serving as a contrast agent for MR, photoacoustic and optical imaging. Furthermore, the nanocomposite functions as a targetable drug nanocarrier and a NIR-laser inducible hyperthermic material that is capable of ablating PANC-1 and MIA PaCa-2 cancer cell lines.
ISSN:	2047-4849
DOI:	10.1039/c6bm00621c