Search Results - "Mitamura, Yasutaka"

Type 2 immunity in the skin and lungs by Akdis, Cezmi A., Arkwright, Peter D., Brüggen, Marie-Charlotte, Busse, William, Gadina, Massimo, Guttman‐Yassky, Emma, Kabashima, Kenji, Mitamura, Yasutaka, Vian, Laura, Wu, Jianni, Palomares, Oscar

“…There has been extensive progress in understanding the cellular and molecular mechanisms of inflammation and immune regulation in allergic diseases of the skin…”
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IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases by Mitamura, Yasutaka, Nunomura, Satoshi, Furue, Masutaka, Izuhara, Kenji

“…Interleukin (IL)-24 is a member of the IL-20 family of cytokines and is produced by various types of cells, such as CD4+ T cells, NK cells, mast cells,…”
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Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease by Celebi Sozener, Zeynep, Ozdel Ozturk, Betul, Cerci, Pamir, Turk, Murat, Gorgulu Akin, Begum, Akdis, Mubeccel, Altiner, Seda, Ozbey, Umus, Ogulur, Ismail, Mitamura, Yasutaka, Yilmaz, Insu, Nadeau, Kari, Ozdemir, Cevdet, Mungan, Dilsad, Akdis, Cezmi A.

“…Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and…”
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Advances and recent developments in asthma in 2020 by Cevhertas, Lacin, Ogulur, Ismail, Maurer, Debbie J., Burla, Daniel, Ding, Mei, Jansen, Kirstin, Koch, Jana, Liu, Chengyao, Ma, Siyuan, Mitamura, Yasutaka, Peng, Yaqi, Radzikowska, Urszula, Rinaldi, Arturo O., Satitsuksanoa, Pattraporn, Globinska, Anna, Veen, Willem, Sokolowska, Milena, Baerenfaller, Katja, Gao, Ya‐dong, Agache, Ioana, Akdis, Mübeccel, Akdis, Cezmi A.

“…In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and…”
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IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis by Vu, Yen Hai, Hashimoto-Hachiya, Akiko, Takemura, Masaki, Yumine, Ayako, Mitamura, Yasutaka, Nakahara, Takeshi, Furue, Masutaka, Tsuji, Gaku

“…Skin barrier dysfunction, including reduced filaggrin (FLG) and loricrin (LOR) expression, plays a critical role in atopic dermatitis (AD) development. Since…”
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Intrinsic TGF-β signaling attenuates proximal tubule mitochondrial injury and inflammation in chronic kidney disease by Kayhan, Merve, Vouillamoz, Judith, Rodriguez, Daymé Gonzalez, Bugarski, Milica, Mitamura, Yasutaka, Gschwend, Julia, Schneider, Christoph, Hall, Andrew, Legouis, David, Akdis, Cezmi A., Peter, Leary, Rehrauer, Hubert, Gewin, Leslie, Wenger, Roland H., Khodo, Stellor Nlandu

“…Excessive TGF-β signaling and mitochondrial dysfunction fuel chronic kidney disease (CKD) progression. However, inhibiting TGF-β failed to impede CKD in…”
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Risk heterogeneity of bullous pemphigoid among dipeptidyl peptidase‐4 inhibitors: A population‐based cohort study using Japanese Latter‐Stage Elderly Healthcare Database by Harano, Yumi, Mitamura, Yasutaka, Jiang, Peng, Fujita, Takako, Babazono, Akira

“…ABSTRACT Aims/Introduction Although the association between dipeptidyl peptidase‐4 (DPP‐4) inhibitors and bullous pemphigoid (BP) has begun to be established,…”
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Hierarchical control of interleukin 13 (IL-13) signals in lung fibroblasts by STAT6 and SOX11 by Mitamura, Yasutaka, Nunomura, Satoshi, Nanri, Yasuhiro, Arima, Kazuhiko, Yoshihara, Tomohito, Komiya, Kosaku, Fukuda, Shogo, Takatori, Hiroaki, Nakajima, Hiroshi, Furue, Masutaka, Izuhara, Kenji

“…Interleukin (IL)-13 is a signature cytokine of type 2 inflammation important for the pathogenesis of various diseases, including allergic diseases. Signal…”
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Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration by Traidl‐Hoffmann, Claudia, Afghani, Jamie, Akdis, Cezmi A., Akdis, Mübecel, Aydin, Handan, Bärenfaller, Katja, Behrendt, Heidrun, Bieber, Thomas, Bigliardi, Paul, Bigliardi‐Qi, Mei, Bonefeld, Charlotte Menné, Bösch, Stefanie, Brüggen, Marie Charlotte, Diemert, Sebastian, Duchna, Hans‐Werner, Fähndrich, Martina, Fehr, Danielle, Fellmann, Marc, Frei, Remo, Garvey, Lena H., Gharbo, Raschid, Gökkaya, Mehmet, Grando, Karin, Guillet, Carole, Guler, Erman, Gutermuth, Jan, Herrmann, Nadine, Hijnen, Dirk Jan, Hülpüsch, Claudia, Irvine, Alan D., Jensen‐Jarolim, Erika, Kong, Heidi H., Koren, Hillel, Lang, Claudia C. V., Lauener, Roger, Maintz, Laura, Mantel, Pierre‐Yves, Maverakis, Emanuel, Möhrenschlager, Matthias, Müller, Svenja, Nadeau, Kari, Neumann, Avidan U., O'Mahony, Liam, Rabenja, Fahafahantsoa Rapelanoro, Renz, Harald, Rhyner, Claudio, Rietschel, Ernst, Ring, Johannes, Roduit, Caroline, Sasaki, Mari, Schenk, Mirjam, Schröder, Jens, Simon, Dagmar, Simon, Hans‐Uwe, Sokolowska, Milena, Ständer, Sonja, Steinhoff, Martin, Piccirillo, Doris Straub, Taïeb, Alain, Takaoka, Roberto, Tapparo, Martin, Teixeira, Henrique, Thyssen, Jacob Pontoppidan, Traidl, Stephan, Uhlmann, Miriam, Veen, Willem, Hage, Marianne, Virchow, Christian, Wollenberg, Andreas, Yasutaka, Mitamura, Zink, Alexander, Schmid‐Grendelmeier, Peter

“…The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by…”
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Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts by Nunomura, Satoshi, Ejiri, Naoko, Kitajima, Midori, Nanri, Yasuhiro, Arima, Kazuhiko, Mitamura, Yasutaka, Yoshihara, Tomohito, Fujii, Kazuki, Takao, Keizo, Imura, Johji, Fehling, Hans Joerg, Izuhara, Kenji, Kitajima, Isao

“…Atopic dermatitis is a chronic inflammatory skin disease with persistent pruritus. To clarify its molecular mechanism, it is important to establish a mouse…”
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Epithelial barrier hypothesis and the development of allergic and autoimmune diseases by Yazici, Duygu, Ogulur, Ismail, Kucukkase, Ozan, Li, Manru, Rinaldi, Arturo O., Pat, Yagiz, Wallimann, Alexandra, Wawrocki, Sebastian, Celebi Sozener, Zeynep, Buyuktiryaki, Betul, Sackesen, Cansin, Akdis, Mubeccel, Mitamura, Yasutaka, Akdis, Cezmi A.

“…The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial barrier–damaging agents…”
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Constitutive overexpression of periostin delays wound healing in mouse skin by Nunomura, Satoshi, Nanri, Yasuhiro, Ogawa, Masahiro, Arima, Kazuhiko, Mitamura, Yasutaka, Yoshihara, Tomohito, Hasuwa, Hidetoshi, Conway, Simon J, Izuhara, Kenji

“…Periostin is a matricellular protein involved in development, maintenance, and regulation of tissues and organs via by binding to cell surface integrin…”
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Induction of Airway Allergic Inflammation by Hypothiocyanite via Epithelial Cells by Suzuki, Shoichi, Ogawa, Masahiro, Ohta, Shoichiro, Nunomura, Satoshi, Nanri, Yasuhiro, Shiraishi, Hiroshi, Mitamura, Yasutaka, Yoshihara, Tomohito, Lee, James J., Izuhara, Kenji

“…Hypothiocyanite (OSCN−) serves as a potent innate defense system against microbes in the lungs. OSCN− is generated by the catalysis of peroxidases using…”
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Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort by Takeuchi, Satoshi, Furusyo, Norihiro, Ono, Junya, Azuma, Yoshinori, Takemura, Masaki, Esaki, Hitokazu, Yamamura, Kazuhiko, Mitamura, Yasutaka, Tsuji, Gaku, Kiyomatsu-Oda, Mari, Hayashi, Jun, Izuhara, Kenji, Furue, Masutaka

“…We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and…”
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NRF2 Activation Inhibits Both TGF-β1- and IL-13-Mediated Periostin Expression in Fibroblasts: Benefit of Cinnamaldehyde for Antifibrotic Treatment by Furue, Masutaka, Mitoma, Chikage, Murai, Mika, Mitamura, Yasutaka

“…Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin…”
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The potential for repositioning antithyroid agents as antiasthma drugs by Suzuki, Shoichi, PhD, Ogawa, Masahiro, PhD, Ohta, Shoichiro, MD, PhD, Arima, Kazuhiko, MD, PhD, Nunomura, Satoshi, PhD, Nanri, Yasuhiro, PhD, Mitamura, Yasutaka, MD, Yoshihara, Tomohito, MD, Nakamura, Yutaka, MD, PhD, Yamauchi, Kohei, MD, PhD, Chibana, Kazuyuki, MD, PhD, Ishii, Yoshiki, MD, PhD, Lee, James J., PhD, Aratani, Yasuaki, PhD, Kakuta, Shigeru, PhD, Kubo, Sachiko, PhD, Iwakura, Yoichiro, PhD, Yoshida, Hiroki, MD, PhD, Izuhara, Kenji, MD, PhD

“…Next, we used mice deficient in each of the 3 peroxidases (Mpo, Epx, and Lpo) to determine which peroxidase dominantly contributes to the setting of allergic…”
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The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma by Yoshihara, Tomohito, Nanri, Yasuhiro, Nunomura, Satoshi, Ogawa, Masahiro, Suzuki, Shoichi, Izuhara, Kenji, Mitamura, Yasutaka

“…Inhaled corticosteroids (ICSs) are used as first-line drugs for asthma, and various novel antiasthma drugs targeting type 2 immune mediators are now under…”
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Clarithromycin attenuates IL-13-induced periostin production in human lung fibroblasts by Komiya, Kosaku, Ohta, Shoichiro, Arima, Kazuhiko, Ogawa, Masahiro, Suzuki, Shoichi, Mitamura, Yasutaka, Nunomura, Satoshi, Nanri, Yasuhiro, Yoshihara, Tomohito, Kawaguchi, Atsushi, Kadota, Jun-Ichi, Rubin, Bruce K, Izuhara, Kenji

“…Periostin is a biomarker indicating the presence of type 2 inflammation and submucosal fibrosis; serum periostin levels have been associated with asthma…”
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Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 1 by Tsuji, Gaku, Hashimoto-Hachiya, Akiko, Yen, Vu Hai, Miake, Sho, Takemura, Masaki, Mitamura, Yasutaka, Ito, Takamichi, Murata, Maho, Furue, Masutaka, Nakahara, Takeshi

“…IL-33, one of the IL-1 superfamily cytokines, has been shown to be associated with pruritus and inflammation in atopic dermatitis (AD). Furthermore, IL-33…”
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Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation by Ioana Agache, Cezmi Akdis, Cezmi Akdis, Mubeccel Akdis, Ali Al-Hemoud, Isabella Annesi-Maesano, Isabella Annesi-Maesano, John Balmes, John Balmes, Lorenzo Cecchi, Athanasios Damialis, Tari Haahtela, Adam L. Haber, Jaime E. Hart, Jaime E. Hart, Marek Jutel, Marek Jutel, Yasutaka Mitamura, Blandina T. Mmbaga, Blandina T. Mmbaga, Jae-Won Oh, Abbas Ostadtaghizadeh, Ruby Pawankar, Mary Prunicki, Harald Renz, Harald Renz, Harald Renz, Mary B. Rice, Nelson Augusto Rosario Filho, Vanitha Sampath, Chrysanthi Skevaki, Chrysanthi Skevaki, Francis Thien, Claudia Traidl-Hoffmann, Claudia Traidl-Hoffmann, Claudia Traidl-Hoffmann, Gary W. K. Wong, Kari C. Nadeau

“…Global warming and climate change have increased the pollen burden and the frequency and intensity of wildfires, sand and dust storms, thunderstorms, and…”
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