USE OF A NEW FORM OF IBUPROFEN IN CHILDREN WITH FEVER AND ACUTE RESPIRATORY TRACT INFECTIONS

USE OF A NEW FORM OF IBUPROFEN IN CHILDREN WITH FEVER AND ACUTE RESPIRATORY TRACT INFECTIONS

Aim: to study clinical efficacy, tolerance and safety of a new pelleted ibuprofen form for children in treatment of fever in patients with acute respiratory tract infection. Patients and methods: children aged from 6 to 12 years old with clinical manifestation of respiratory tract infections and req...

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Bibliographic Details
Published in:Voprosy sovremennoĭ pediatrii Vol. 12; no. 4; pp. 166 - 171
Main Authors: Lokshina, E. E., Zaitseva, S. V., Zaitseva, O. V., Klendar, G. A., Stepanova, I. G., Misurenko, O. N., Selivanova, I. N., Shamonina, N. V., Kasatkina, M. S., Ravshanova, L. S.
Format: Journal Article
Language:English
Published: "Paediatrician" Publishers LLC 12-07-2013
Subjects:
acute respiratory tract infections
children
fever
ibuprofen
pain
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Summary:Aim: to study clinical efficacy, tolerance and safety of a new pelleted ibuprofen form for children in treatment of fever in patients with acute respiratory tract infection. Patients and methods: children aged from 6 to 12 years old with clinical manifestation of respiratory tract infections and requiring antipyretic treatment were included into the study. Children (n = 50) were administered ibuprofen at a single dose of 5–10 mg/kg of body weight, not more than 3–4 times per day. The efficacy assessment included time needed for temperature decrease (assessment was performed in 15, 30 and 60 minutes) and duration of the antipyretic effect (assessment in 6, 8 and 12 hours). Rapidity of analgesic effect in children with ear ache, headache and myalgias was performed in 15, 30, 60 minutes and 6, 8 and 12 hours after the drug intake. Results: antipyretic effect of pelleted ibuprofen for children begins in 15 minutes after its intake. Stable temperature decrease during the first 6 hours was observed in 58% of children (the mean temperature was 37,1 ± 0,3) and maintained up for 12 hours. Relief of pain intensity was established in 62,1% of patients during the first 3 hours, and in 37,9% the pain syndrome was arrested completely. Conclusions: the new pelleted form of ibuprofen for children was proved to have high clinical efficacy and safety in treatment of fever in children with acute respiratory tract infections.
ISSN:1682-5535
1682-5527
1682-5535
DOI:10.15690/vsp.v12i4.746