Search Results - "Mistrik, Pavel"

A preoperative dose of the pyridoindole AC102 improves the recovery of residual hearing in a gerbil animal model of cochlear implantation by Nieratschker, Michael, Yildiz, Erdem, Gerlitz, Matthias, Bera, Sujoy, Gadenstaetter, Anselm J., Kramer, Anne-Margarethe, Kwiatkowska, Monika, Mistrik, Pavel, Landegger, Lukas D., Braun, Susanne, Schlingensiepen, Reimar, Honeder, Clemens, Arnoldner, Christoph, Rommelspacher, Hans

“…Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Due to the heterogeneity of causes for SNHL, effective treatment options remain…”
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Computational Evaluation of Cochlear Implant Surgery Outcomes Accounting for Uncertainty and Parameter Variability by Mangado, Nerea, Pons-Prats, Jordi, Coma, Martí, Mistrík, Pavel, Piella, Gemma, Ceresa, Mario, González Ballester, Miguel Á

“…Cochlear implantation (CI) is a complex surgical procedure that restores hearing in patients with severe deafness. The successful outcome of the implanted…”
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NANOCI—Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons by Senn, Pascal, Roccio, Marta, Hahnewald, Stefan, Frick, Claudia, Kwiatkowska, Monika, Ishikawa, Masaaki, Bako, Peter, Li, Hao, Edin, Fredrik, Liu, Wei, Rask-Andersen, Helge, Pyykkö, Ilmari, Zou, Jing, Mannerström, Marika, Keppner, Herbert, Homsy, Alexandra, Laux, Edith, Llera, Miguel, Lellouche, Jean-Paul, Ostrovsky, Stella, Banin, Ehud, Gedanken, Aharon, Perkas, Nina, Wank, Ute, Wiesmüller, Karl-Heinz, Mistrík, Pavel, Benav, Heval, Garnham, Carolyn, Jolly, Claude, Gander, Filippo, Ulrich, Peter, Müller, Marcus, Löwenheim, Hubert

“…Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain…”
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The Murine HCN3 Gene Encodes a Hyperpolarization-activated Cation Channel with Slow Kinetics and Unique Response to Cyclic Nucleotides by Mistrík, Pavel, Mader, Robert, Michalakis, Stylianos, Weidinger, Martha, Pfeifer, Alexander, Biel, Martin

“…Hyperpolarization-activated cation channels of the HCN gene family are crucial for the regulation of cell excitability. Importantly, these channels play a…”
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The role of potassium recirculation in cochlear amplification by Mistrik, Pavel, Ashmore, Jonathan

“…Normal cochlear function depends on maintaining the correct ionic environment for the sensory hair cells. Here we review recent literature on the cellular…”
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A Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase[boxs] by Zong, Xiangang, Eckert, Christian, Yuan, Haixin, Wahl-Schott, Christian, Abicht, Heike, Fang, Longfou, Li, Rongxia, Mistrik, Pavel, Gerstner, Andrea, Much, Barbara, Baumann, Ludwig, Michalakis, Stylianos, Zeng, Rong, Chen, Zhengjun, Biel, Martin

“…Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) play a crucial role in the regulation of cell excitability. Importantly, they contribute…”
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Three-dimensional current flow in a large-scale model of the cochlea and the mechanism of amplification of sound by Mistrík, Pavel, Mullaley, Chris, Mammano, Fabio, Ashmore, Jonathan

“…) recirculation. We have included experimentally determined parameters of cochlear macromechanics, which govern sound transduction, and data on hair cells'…”
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Silicone-based AC102-loaded cochlear implant coatings protect residual hearing in an animal model of cochlear implantation by Nieratschker, Michael, Mistrik, Pavel, Petrasek, Zdenek, Yildiz, Erdem, Gadenstaetter, Anselm J., Gerlitz, Matthias, Kramer, Anne-Margarethe, Kwiatkowska, Monika, Braun, Susanne, Schlingensiepen, Reimar, Honeder, Clemens, Arnoldner, Christoph

“…•The Higuchi model of drug release predicts the release from AC102-loaded electrodes.•AC102-loaded electrodes reduce CAP threshold shifts in the middle and low…”
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Reduced Electromotility of Outer Hair Cells Associated with Connexin-Related Forms of Deafness: An In silico Study of a Cochlear Network Mechanism by Mistrík, Pavel, Ashmore, Jonathan F.

“…Mutations in the GJB2 gene encoding for the connexin 26 (Cx26) protein are the most common source of nonsyndromic forms of deafness. Cx26 is a building block…”
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Challenging aspects of contemporary cochlear implant electrode array design by Mistrík, Pavel, Jolly, Claude, Sieber, Daniel, Hochmair, Ingeborg

“…Objective A design comparison of current perimodiolar and lateral wall electrode arrays of the cochlear implant (CI) is provided. The focus is on functional…”
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The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration by Mistrík, Pavel, Pfeifer, Alexander, Biel, Martin

“…The hyperpolarization-activated cation current I (f) plays a key role in the modulation of rhythmic activity in cardiac pacemaker cells and spontaneously…”
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Functional simulation of the cochlea for implant optimization by Ceresa, Mario, Perez, Frederic, Vera, Sergio, Carranza, Noemi, Herrero Jover, Javier, Mistrik, Pavel, Gonzalez Ballester, Miguel A.

“…Cochlear implantation is a surgical technique which aims to restore hearing in people with deep hearing loss. However, outcomes of the surgery still exhibit a…”
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Towards a Complete In Silico Assessment of the Outcome of Cochlear Implantation Surgery by Mangado, Nerea, Ceresa, Mario, Benav, Heval, Mistrik, Pavel, Piella, Gemma, González Ballester, Miguel A.

“…Cochlear implantation (CI) surgery is a very successful technique, performed on more than 300,000 people worldwide. However, since the challenge resides in…”
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A multiscale imaging and modelling dataset of the human inner ear by Gerber, Nicolas, Reyes, Mauricio, Barazzetti, Livia, Kjer, Hans Martin, Vera, Sergio, Stauber, Martin, Mistrik, Pavel, Ceresa, Mario, Mangado, Nerea, Wimmer, Wilhelm, Stark, Thomas, Paulsen, Rasmus R., Weber, Stefan, Caversaccio, Marco, Ballester, Miguel A. González

“…Understanding the human inner ear anatomy and its internal structures is paramount to advance hearing implant technology. While the emergence of imaging…”
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Automatic Model Generation Framework for Computational Simulation of Cochlear Implantation by Mangado, Nerea, Ceresa, Mario, Duchateau, Nicolas, Kjer, Hans Martin, Vera, Sergio, Dejea Velardo, Hector, Mistrik, Pavel, Paulsen, Rasmus R., Fagertun, Jens, Noailly, Jérôme, Piella, Gemma, González Ballester, Miguel Ángel

“…Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However,…”
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From the outer ear to the nerve: A complete computer model of the peripheral auditory system by Tichacek, Ondrej, Mistrík, Pavel, Jungwirth, Pavel

“…Computer models of the individual components of the peripheral auditory system - the outer, middle, and inner ears and the auditory nerve - have been developed…”
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Cochlear implant electrode localization in post-operative CT using a spherical measure by Braithwaite, Benjamin, Kjer, H. Martin, Fagertun, Jens, Gonzalez Ballester, Miguel A., Dhanasingh, Anandhan, Mistrik, Pavel, Gerber, Nicolas, Paulsen, Rasmus R.

“…When implanting cochlear implants the positions of electrodes have a large impact on the quality of the restored hearing. Due to metal artifacts it is…”
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Patient-specific simulation of implant placement and function for cochlear implantation surgery planning by Ceresa, Mario, Lopez, Nerea Mangado, Velardo, Hector Dejea, Herrezuelo, Noemi Carranza, Mistrik, Pavel, Kjer, Hans Martin, Vera, Sergio, Paulsen, Rasmus R, González Ballester, Miguel Angel

“…We present a framework for patient specific electrical stimulation of the cochlea, that allows to perform in-silico analysis of implant placement and function…”
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Virtual cochlear electrode insertion via parallel transport frame by Duchateau, N., Mangado, N., Ceresa, M., Mistrik, P., Vera, S., Gonzalez Ballester, M. A.

“…We present an automatic, fast and parametrizable algorithm to perform the virtual insertion of a cochlear electrode array into a pre-existent mesh of the human…”
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Pore topology of the hyperpolarization-activated cyclic nucelotide-gated channel from sea urchin sperm by Roncaglia, Paola, Mistrik, Pavel, Torre, Vincent

“…The current flow through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, referred to as Ih, plays a major role in several fundamental…”
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