Search Results - "Misteli, T"

Controlled droplet discretization and manipulation using membrane displacement traps by Padmanabhan, S, Misteli, T, DeVoe, D L

“…An innovative platform enabling complex discretization and manipulation of aqueous droplets is described. The system uses simple membrane displacement trap…”
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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome by Misteli, Tom, Scaffidi, Paola

“…Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of…”
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Functional architecture in the cell nucleus by Dundr, M, Misteli, T

“…The major functions of the cell nucleus, including transcription, pre-mRNA splicing and ribosome assembly, have been studied extensively by biochemical,…”
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Cancer epigenetics: from disruption of differentiation programs to the emergence of cancer stem cells by Scaffidi, P, Misteli, T

“…Cancer is a disease of the genome. Whereas efforts to understand the molecular basis of cancer have in the past largely focused on the role of mutations,…”
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high-throughput system for segmenting nuclei using multiscale techniques by Gudla, Prabhakar R, Nandy, K, Collins, J, Meaburn, K.J, Misteli, T, Lockett, S.J

“…Automatic segmentation of cell nuclei is critical in several high-throughput cytometry applications whereas manual segmentation is laborious and…”
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Analysis of nuclear actin in human progeria cells by Takahashi, Y., Machida, N., Misteli, T., Grosse, R., Miyamoto, K., Harata, M.

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature disorder caused by de novo single base substitution in the lamin A gene. Lamin A contributes to…”
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The Dynamics of Postmitotic Reassembly of the Nucleolus by Dundr, Miroslav, Misteli, Tom, Mark O. J. Olson

“…Mammalian cell nucleoli disassemble at the onset of M-phase and reassemble during telophase. Recent studies showed that partially processed preribosomal RNA…”
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Beyond the Sequence: Cellular Organization of Genome Function by Misteli, Tom

“…Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their…”
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On the Contribution of Spatial Genome Organization to Cancerous Chromosome Translocations by Soutoglou, Evi, Misteli, Tom

“…The formation of cancer translocations requires the physical interaction of the translocating chromosomes. It has been postulated that the nonrandom spatial…”
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Segmentation of Whole Cells and Cell Nuclei From 3-D Optical Microscope Images Using Dynamic Programming by McCullough, D.P., Gudla, P.R., Harris, B.S., Collins, J.A., Meaburn, K.J., Nakaya, M.-A., Yamaguchi, T.P., Misteli, T., Lockett, S.J.

“…Communications between cells in large part drive tissue development and function, as well as disease-related processes such as tumorigenesis. Understanding the…”
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Higher-order genome organization in human disease by Misteli, Tom

“…Genomes are organized into complex higher-order structures by folding of the DNA into chromatin fibers, chromosome domains, and ultimately chromosomes. The…”
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Time-Resolved Analysis and Visualization of Dynamic Processes in Living Cells by Tvaruskó, W., Bentele, M., Misteli, T., Rudolf, R., Kaether, C., Spector, D. L., Gerdes, H. H., Eils, R.

“…Recent development of in vivo microscopy techniques, including green fluorescent proteins, has allowed the visualization of a wide range of dynamic processes…”
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Spatial genome organization during T-cell differentiation by Kim, S H, McQueen, P G, Lichtman, M K, Shevach, E M, Parada, L A, Misteli, T

“…The spatial organization of genomes within the mammalian cell nucleus is non-random. The functional relevance of spatial genome organization might be in…”
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Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors by Misteli, T, Spector, D L

“…HeLa cell nuclei were permeabilized and reconstituted with nuclear extract to identify soluble nuclear factors which play a role in the organization of…”
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Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing by Misteli, Tom, Scaffidi, Paola

“…The premature-ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by constitutive production of progerin, a mutant form of the nuclear…”
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Mitotic Phosphorylation Prevents the Binding of HMGN Proteins to Chromatin by Prymakowska-Bosak, M, Misteli, T, Herrera, J E, Shirakawa, H, Birger, Y, Garfield, S, Bustin, M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Spatial Positioning: A New Dimension in Genome Function by Misteli, Tom

“…The eukaryotic cell nucleus is a heterogeneous organelle. Chromosomes are nonrandomly positioned within the nuclear space, and individual gene loci experience…”
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Where the nucleus comes from by Misteli, Tom

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Biogenesis of nuclear bodies by Dundr, Miroslav, Misteli, Tom

“…The nucleus is unique amongst cellular organelles in that it contains a myriad of discrete suborganelles. These nuclear bodies are morphologically and…”
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The lamin protein family by Dittmer, Travis A, Misteli, Tom

“…The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for…”
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