Search Results - "Missios, Pavlos"

Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target by Franses, Joseph W., Philipp, Julia, Missios, Pavlos, Bhan, Irun, Liu, Ann, Yashaswini, Chittampalli, Tai, Eric, Zhu, Huili, Ligorio, Matteo, Nicholson, Benjamin, Tassoni, Elizabeth M., Desai, Niyati, Kulkarni, Anupriya S., Szabolcs, Annamaria, Hong, Theodore S., Liss, Andrew S., Fernandez-del Castillo, Carlos, Ryan, David P., Maheswaran, Shyamala, Haber, Daniel A., Daley, George Q., Ting, David T.

“…Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs)…”
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The developmental stage of the hematopoietic niche regulates lineage in MLL- rearranged leukemia by Rowe, R Grant, Lummertz da Rocha, Edroaldo, Sousa, Patricia, Missios, Pavlos, Morse, Michael, Marion, William, Yermalovich, Alena, Barragan, Jessica, Mathieu, Ronald, Jha, Deepak Kumar, Fleming, Mark D, North, Trista E, Daley, George Q

“…Leukemia phenotypes vary with age of onset. Delineating mechanisms of age specificity in leukemia could improve disease models and uncover new therapeutic…”
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Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma by Bitzer, Michael, Spahn, Stephan, Babaei, Sepideh, Horger, Marius, Singer, Stephan, Schulze-Osthoff, Klaus, Missios, Pavlos, Gatidis, Sergios, Nann, Dominik, Mattern, Sven, Scheble, Veit, Nikolaou, Konstantin, Armeanu-Ebinger, Sorin, Schulze, Martin, Schroeder, Christopher, Biskup, Saskia, Beha, Janina, Claassen, Manfred, Ruhm, Kristina, Poso, Antti, Malek, Nisar P.

“…Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions. In…”
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LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors by Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., Look, A. Thomas

“…LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 micro-RNA biogenesis. Here, we report…”
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LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy by Missios, Pavlos, da Rocha, Edroaldo Lummertz, Pearson, Daniel S, Philipp, Julia, Aleman, Maria M, Pirouz, Mehdi, Farache, Dorian, Franses, Joseph W, Kubaczka, Caroline, Tsanov, Kaloyan M, Jha, Deepak K, Pepe-Mooney, Brian, Powers, John T, Gregory, Richard I, Lee, Amy Sy, Dominguez, Daniel, Ting, David T, Daley, George Q

“…High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed…”
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Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice by Missios, Pavlos, Zhou, Yuan, Guachalla, Luis Miguel, von Figura, Guido, Wegner, Andre, Chakkarappan, Sundaram Reddy, Binz, Tina, Gompf, Anne, Hartleben, Götz, Burkhalter, Martin D., Wulff, Veronika, Günes, Cagatay, Sattler, Rui Wang, Song, Zhangfa, Illig, Thomas, Klaus, Susanne, Böhm, Bernhard O., Wenz, Tina, Hiller, Karsten, Rudolph, K. Lenhard

“…DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral glucose administration at advanced age increases health and lifespan of…”
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The Age of the Hematopoietic Microenvironment Specifies Lineage Commitment in MLL-Rearranged Leukemia by Rowe, Grant, Lummertz da Rocha, Edroaldo, Sousa, Patricia, Missios, Pavlos, Morse, Michael, Barragan, Jessica, Mathieu, Ronald, Daley, George Q

“…Leukemias are a heterogenous group of hematologic malignancies classified by their pathobiologic characteristics including differentiation lineage (myeloid,…”
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Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer by Eser, Pınar Özden, Paranal, Raymond M, Son, Jieun, Ivanova, Elena, Kuang, Yanan, Haikala, Heidi M, To, Ciric, Okoro, Jeffrey J, Dholakia, Kshiti H, Choi, Jihyun, Eum, Yoonji, Ogino, Atsuko, Missios, Pavlos, Ercan, Dalia, Xu, Man, Poitras, Michael J, Wang, Stephen, Ngo, Kenneth, Dills, Michael, Yanagita, Masahiko, Lopez, Timothy, Lin, Mika, Tsai, Jeanelle, Floch, Nicolas, Chambers, Emily S, Heng, Jennifer, Anjum, Rana, Santucci, Alison D, Michael, Kesi, Schuller, Alwin G, Cross, Darren, Smith, Paul D, Oxnard, Geoffrey R, Barbie, David A, Sholl, Lynette M, Bahcall, Magda, Palakurthi, Sangeetha, Gokhale, Prafulla C, Paweletz, Cloud P, Daley, George Q, Jänne, Pasi A

“…The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in -mutant non–small cell lung cancer is limited by the development of drug…”
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Abstract 1732: Switch to MET oncogene dependence as a novel mechanism of drug resistance in EGFR- mutant lung cancer by Eser, Pinar Ö., Paranal, Raymond M., Poitras, Michael J., Xu, Man, Wang, Stephen, Ogino, Atsuko, Choi, Jihyun, Missios, Pavlos, Haikala, Heidi M., Son, Jieun, Lin, Mika, Yanagita, Masahiko, Gokhale, Prafulla C., Daley, George Q., Jänne, Pasi A.

“…Abstract Introduction: Non-small cell lung cancers harboring sensitizing gain-of-function mutations in the epidermal growth factor receptor (EGFR) are treated…”
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Novel Epigenetic Vulnerabilities for Diffuse Large B-Cell Lymphoma by Jha, Deepak, Daley, George Q., Laurent, Benoit, Zhang, Cheng, Kubaczka, Caroline, Chapuy, Bjoern, Sousa, Patricia, Missios, Pavlos, Rowe, R. Grant, Huang, Yu-Chung, Tan, Yang, Barragan, Jessica, North, Trista, Schlaeger, Thorsten, Li, Hu, Shi, Yang, Shipp, Margaret A.

“…Diffuse Large B Cell Lymphoma (DLBCL) is the most common form of B-cell Non-Hodgkin Lymphoma (NHL), representing a third of all new cases. DLBCL is further…”
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Abstract 1040: LIN28B-mediated let-7 independent activation of AKT promotes neuroblastoma pathogenesis by Tao, Ting, Powers, John T., Shi, Hui, Missios, Pavlos, Perez-Atayde, Antonio R., Zhu, Shizhen, Daley, George Q., Look, Thomas A.

“…Abstract LIN28 is well known as a RNA-binding protein and a suppressor of microRNA biogenesis, by selectively blocking the processing of let-7 precursors. It…”
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3090 – KDM4A/C SUSTAIN AN ONCOGENIC PROGRAM BY EPIGENETIC REWIRING OF ONCOGENIC AND LINEAGE ENHANCERS by Jha, Deepak, Daley, George, Dominguez, Daniel, Keogh, Michael-Christopher, Li, Hu, Schlaeger, Thorsten, Shi, Yang, Shipp, Margaret, Bhan, Arunoday, Chapuy, Bjoern, Cote, Claire, da Rocha, Edroaldo, Gillespie, Zachary, Howard, Sarah, Huang, Yu-Chung, Jing, Ran, Marunde, Matthew, Missios, Pavlos, Morris, Vivian, Morse, Michael, North, Trista, Rowe, Robert, Tang, Yang, Najia, Mohamad Toufic, Vaidya, Anup, Kubaczka, Caroline, Laurent, Benoit, Zhang, Cheng

“…Many prior studies have focused on the role of mutations in epigenetic factors in cancer (e.g., EZH2, CREBBP, EP300, KMT2C, KMT2D) but drugs targeting these…”
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Das molekulare Tumorboard by Missios, Pavlos, Beha, Janina, Bitzer, Michael, Malek, Nisar P.

“…Zusammenfassung Hintergrund Nach Einführung neuer Sequenzierungsmethoden ergeben sich neue Möglichkeiten in der Diagnostik maligner Erkrankungen. Dies…”
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The molecular tumor board by Missios, Pavlos, Beha, Janina, Bitzer, Michael, Malek, Nisar P

“…BACKGROUNDNew diagnostic tools in the field of oncology that became available with introduction of the next generation sequencing call for adjustments in the…”
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Transgastric biliary drainage through a biliodigestive efferent loop using a lumen-apposing metal stent by Büringer, Karsten, Fusco, Stefano, Wichmann, Dörte, Schempf, Ulrike, Missios, Pavlos, Stein-Thöringer, Christoph, Zinsser, Dominik, Malek, Nisar P., Werner, Christoph R.

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Das molekulare Tumorboard by Missios, Pavlos, Beha, Janina, Bitzer, Michael, Malek, Nisar P.

“…Zusammenfassung Hintergrund Nach Einführung neuer Sequenzierungsmethoden ergeben sich neue Möglichkeiten in der Diagnostik maligner Erkrankungen. Dies…”
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