Search Results - "Misra, Saurav"

A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase by Shang, Pengcheng, Misra, Saurav, Hause, Ben, Fang, Ying

“…Enteroviruses (EVs) are implicated in a wide range of diseases in humans and animals. In this study, a novel enterovirus (enterovirus species G [EVG]) (EVG…”
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Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase by Stuehr, Dennis J., Misra, Saurav, Dai, Yue, Ghosh, Arnab

“…Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates many molecules of cGMP in response to its ligand nitric oxide (NO);…”
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Antiviral Effects of Ivermectin in COVID-19- Clinically Plausible? by Shukla, Dr. Ajay Kumar, Misra, Dr. Saurav

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Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism by Dai, Yue, Schlanger, Simon, Haque, Mohammad Mahfuzul, Misra, Saurav, Stuehr, Dennis J.

“…The enzyme soluble guanylyl cyclase (sGC) is a heterodimer composed of an α subunit and a heme-containing β subunit. It participates in signaling by generating…”
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A coevolution-guided model for the rotor of the bacterial flagellar motor by Khan, Shahid, Guo, Tai Wei, Misra, Saurav

“…The Salmonella typhimurium trans-membrane FliF MS ring templates assembly of the rotary bacterial flagellar motor, which also contains a cytoplasmic C-ring. A…”
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A swine arterivirus deubiquitinase stabilizes two major envelope proteins and promotes production of viral progeny by Guo, Rui, Yan, Xingyu, Li, Yanhua, Cui, Jin, Misra, Saurav, Firth, Andrew E, Snijder, Eric J, Fang, Ying

“…Arteriviruses are enveloped positive-strand RNA viruses that assemble and egress using the host cell's exocytic pathway. In previous studies, we demonstrated…”
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Agreement between WHO-UMC causality scale and the Naranjo algorithm for causality assessment of adverse drug reactions by Shukla, Ajay, Jhaj, Ratinder, Misra, Saurav, Ahmed, Shah, Nanda, Malaya, Chaudhary, Deepa

“…Background: The Pharmacovigilance Program of India recommends the use of the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) scale, while many…”
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Structure of an integrin αIIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation by Yang, Jun, Ma, Yan-Qing, Page, Richard C, Misra, Saurav, Plow, Edward F, Qin, Jun

“…Heterodimeric integrin adhesion receptors regulate diverse biological processes including angiogenesis, thrombosis and wound healing. The…”
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A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins by Zhang, Huaqun, Amick, Joseph, Chakravarti, Ritu, Santarriaga, Stephanie, Schlanger, Simon, McGlone, Cameron, Dare, Michelle, Nix, Jay C., Scaglione, K. Matthew, Stuehr, Dennis J., Misra, Saurav, Page, Richard C.

“…The ubiquitin ligase CHIP plays an important role in cytosolic protein quality control by ubiquitinating proteins chaperoned by Hsp70/Hsc70 and Hsp90, thereby…”
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Treatment Cost Along With Pattern of Disease and Therapy in the Intensive Care Unit of a Tertiary Care Teaching Hospital in India by Atal, Shubham, Najmi, Ahmad, Pathan, Saman, Misra, Saurav, Santenna, Chenchula

“…Background The intensive care unit (ICU) represents an important platform for conducting drug utilization analysis using defined daily dose (DDD)/100 bed-days…”
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Act1, a U-box E3 ubiquitin ligase for IL-17 signaling by Liu, Caini, Qian, Wen, Qian, Youcun, Giltiay, Natalia V, Lu, Yi, Swaidani, Shadi, Misra, Saurav, Deng, Li, Chen, Zhijian J, Li, Xiaoxia

“…Interleukin-17 (IL-17), a proinflammatory cytokine mainly produced by cells of the T helper 17 (T(H)17) lineage, is required for host defense against bacterial…”
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Safety monitoring of precautionary third dose of COVID-19 vaccines in a district in Northern India by Deb, Tirthankar, Misra, Saurav, Kaur, Manmeet, Verma, Neelam, Kairi, Jayant Kumar, Sindhu, Nitika

“…The World Health Organization (WHO) declared Coronavirus disease-19 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) a…”
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Adverse events following Covaxin administration among adolescents (15-18 years) - A pharmacovigilance study in a district in Northern India by Deb, Tirthankar, Kaur, Manmeet, Misra, Saurav, Verma, Neelam, Sindhu, Nitika, Kairi, Jayant

“…The study was undertaken to observe the adverse event following immunization (AEFI) to the Covaxin vaccine in young adolescents in the age group of 15-18 years…”
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Clinical inertia in elderly for vaccination by Shukla, Ajay, Misra, Saurav

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Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics by Choudhary, Gaurav S, Tat, Trinh T, Misra, Saurav, Hill, Brian T, Smith, Mitchell R, Almasan, Alexandru, Mazumder, Suparna

“…Cyclin E/Cdk2 kinase activity is frequently deregulated in human cancers, resulting in impaired apoptosis. Here, we show that cyclin E/Cdk2 phosphorylates and…”
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Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase by Ye, Zhaofeng, Needham, Patrick G., Estabrooks, Samuel K., Whitaker, Susan K., Garcia, Brandon L., Misra, Saurav, Brodsky, Jeffrey L., Camacho, Carlos J.

“…C-terminus of Hsc/p70-Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase. Each CHIP monomer consists of a tetratricopeptide-repeat (TPR),…”
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Crystal structure of the nucleotide‐binding domain of mortalin, the mitochondrial Hsp70 chaperone by Amick, Joseph, Schlanger, Simon E., Wachnowsky, Christine, Moseng, Mitchell A., Emerson, Corey C., Dare, Michelle, Luo, Wen‐I, Ithychanda, Sujay S., Nix, Jay C., Cowan, J. A., Page, Richard C., Misra, Saurav

“…Mortalin, a member of the Hsp70‐family of molecular chaperones, functions in a variety of processes including mitochondrial protein import and quality control,…”
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Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2 by Herr, Andrew B, Patterson, Cam, Nix, Jay C, Xu, Zhen, Kohli, Ekta, Misra, Saurav, Gomes, Michelle M, Page, Richard C

“…Bag2 acts as a nucleotide-exchange factor for Hsp70 and also binds misfolded substrates. Now structural work reveals that Bag2 promotes nucleotide exchange via…”
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Apical targeting of syntaxin 3 is essential for epithelial cell polarity by Sharma, Nikunj, Low, Seng Hui, Misra, Saurav, Pallavi, Bhattaram, Weimbs, Thomas

“…In polarized epithelial cells, syntaxin 3 localizes to the apical plasma membrane and is involved in membrane fusion of apical trafficking pathways. We show…”
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Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes by Xu, Zhen, Kohli, Ekta, Devlin, Karl I, Bold, Michael, Nix, Jay C, Misra, Saurav

“…Ubiquitin (E3) ligases interact with specific ubiquitin conjugating (E2) enzymes to ubiquitinate particular substrate proteins. As the combination of E2 and E3…”
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