Search Results - "Misra, Pinaki"

Alpha‐Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure by Singer, Wolfgang, Schmeichel, Ann M., Shahnawaz, Mohammad, Schmelzer, James D., Sletten, David M., Gehrking, Tonette L., Gehrking, Jade A., Olson, Anita D., Suarez, Mariana D., Misra, Pinaki P., Soto, Claudio, Low, Phillip A.

“…Objective To explore the role of alpha‐synuclein (αSyn) oligomers and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) of patients with pure…”
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Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway by Misra, Pinaki, Kodali, Ravindra, Chemuru, Saketh, Kar, Karunakar, Wetzel, Ronald

“…Since early oligomeric intermediates in amyloid assembly are often transient and difficult to distinguish, characterize and quantify, the mechanistic basis of…”
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Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation by Blancas-Mejía, Luis M, Misra, Pinaki, Ramirez-Alvarado, Marina

“…Light chain (AL) amyloidosis is a lethal disease characterized by the deposition of the immunoglobulin light chain into amyloid fibrils, resulting in organ…”
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Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells by Jordan, Torri L., Maar, Khansaa, Redhage, Keely R., Misra, Pinaki, Blancas-Mejia, Luis M., Dick, Christopher J., Wall, Jonathan S., Williams, Angela, Dietz, Allan B., van Wijnen, Andre J., Lin, Yi, Ramirez-Alvarado, Marina

“…Light chain (AL) amyloidosis is a progressive, degenerative disease characterized by the misfolding and amyloid deposition of immunoglobulin light chain (LC)…”
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Volumetric and calorimetric investigations of molecular interactions in some amino acids and peptides in the combined presence of surfactants and glycine betaine by Misra, Pinaki P., Kishore, Nand

“…► Glycine betaine in presence of surfactants shows enhanced polar interaction in amino acids with small –R groups. ► Both HTAB and SDS at post CMC shows polar…”
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Biophysical analysis of partially folded state of α-lactalbumin in the presence of cationic and anionic surfactants by Misra, Pinaki P., Kishore, Nand

“…Structural changes in bovine α-lactalbumin in presence of cationic and anionic surfactants and the role of different interactions in the stability of molten…”
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Pathologic light chain amyloidosis oligomer detection in urinary extracellular vesicles as a diagnostic tool for response and progression of disease by Cooper, Shawna A., Dick, Christopher J., Misra, Pinaki, Leung, Nelson, Schinstock, Carrie A., Ramirez-Alvarado, Marina

“…Light Chain (AL) Amyloidosis is a plasma cell dyscrasia producing amyloidogenic light chains (LC) that misfold and form amyloid deposits that cause damage in…”
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Glycine betaine: A widely reported osmolyte induces differential and selective conformational stability and enhances aggregation in some proteins in the presence of surfactants by Misra, Pinaki P., Kishore, Nand

“…In this study, we extensively report the effect of glycine betaine during the refolding of partially folded bovine α‐lactalbumin (α‐LA) in presence of…”
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Differential Modulation in Binding of Ketoprofen to Bovine Serum Albumin in the Presence and Absence of Surfactants: Spectroscopic and Calorimetric Insights by Misra, Pinaki P., Kishore, Nand

“…Surfactants have long been implicated in the unique static and dynamic effect on the structure and function of serum albumins. However, there is very little…”
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Early events in light chain aggregation at physiological pH reveal new insights on assembly, stability, and aggregate dissociation by Misra, Pinaki, Ramirez-Alvarado, Marina

“…Early events in immunoglobulin light chain (AL) amyloid formation are especially important as some early intermediates formed during the aggregation reaction…”
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Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains by Misra, Pinaki, Blancas-Mejia, Luis M, Ramirez-Alvarado, Marina

“…Little is known about the mechanism of amyloid assembly in immunoglobulin light chain (AL) amyloidosis, in contrast to other amyloid diseases. Early events in…”
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An Aggregate Weight-Normalized Thioflavin-T Measurement Scale for Characterizing Polymorphic Amyloids and Assembly Intermediates by Wetzel, Ronald, Chemuru, Saketh, Misra, Pinaki, Kodali, Ravi, Mukherjee, Smita, Kar, Karunakar

“…The red shift in the fluorescence excitation spectra of thioflavin dyes upon binding to fibrils has been a boon to the amyloid field, offering simple and…”
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Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chains by Misra, Pinaki, Tischer, Alexander, Lampe, Lindsey, Pierluissi-Ruiz, Valeria, Dick, Christopher J., Bragantini, Benoit, Kormshchikov, Nikita, Auton, Matthew, Ramirez-Alvarado, Marina

“…Immunoglobulin light chain (AL) amyloidosis involves the deposition of insoluble monoclonal AL protein fibrils in the extracellular space of different organs…”
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Structural Insights into Aggregation Mechanism of Immunoglobulin Light Chain Variable Domain by Misra, Pinaki, Blancas Mejia, Luis, Ramirez-Alvarado, Marina

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Cell Damage in Light Chain Amyloidosis: FIBRIL INTERNALIZATION, TOXICITY AND CELL-MEDIATED SEEDING by Marin-Argany, Marta, Lin, Yi, Misra, Pinaki, Williams, Angela, Wall, Jonathan S, Howell, Kyle G, Elsbernd, Laura R, McClure, Megan, Ramirez-Alvarado, Marina

“…Light chain (AL) amyloidosis is an incurable human disease characterized by the misfolding, aggregation, and systemic deposition of amyloid composed of…”
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Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure (S30.002) by Singer, Wolfgang, Schmeichel, Ann, Shahnawaz, Mohammad, Schmelzer, James, Sletten, David, Gehrking, Tonette, Gehrking, Jade, Suarez, Mariana, Misra, Pinaki, Soto, Claudio, Low, Phillip

“…Abstract only…”
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Blood-Based Nanoparticle-Enhanced Quaking-Induced Conversion (Nano-QuIC): Inhibitor-Resistant Detection of Seeding Activity in Patients Diagnosed with Parkinson’s Disease by Christenson, Peter R., Jeong, Hyeonjeong, Li, Manci, Ahn, Hyerim, Schmeichel, Ann M., Misra, Pinaki, Li, Danni, Savica, Rodolfo, Low, Phillip A., Singer, Wolfgang, Larsen, Peter A., Park, Hye Yoon, Oh, Sang-Hyun

“…A hallmark of α-synucleinopathies (e.g., Parkinson's disease) is the misfolding and aggregation of α-synuclein in tissues and biological fluids. Protein…”
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Target engagement and immunogenicity of an active immunotherapeutic targeting pathological α-synuclein: a phase 1 placebo-controlled trial by Eijsvogel, Pepijn, Misra, Pinaki, Concha-Marambio, Luis, Boyd, Justin D., Ding, Shuang, Fedor, Lauren, Hsieh, Yueh-Ting, Sun, Yu Shuang, Vroom, Madeline M., Farris, Carly M., Ma, Yihua, de Kam, Marieke L., Radanovic, Igor, Vissers, Maurits F. J. M., Mirski, Dario, Shareghi, Ghazal, Shahnawaz, Mohammad, Singer, Wolfgang, Kremer, Philip, Groeneveld, Geert Jan, Yu, Hui Jing, Dodart, Jean-Cosme

“…Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson’s disease…”
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Insights into the Genesis of Light Chain Amyloid Assembly by Misra, Pinaki P., Blancas-Mejia, Luis M., Ramirez-Alvarado, Marina

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A comprehensive Analysis of Bovine αα-Lactalbumin Molten Globule in Presence of Surfactants: Biophysical Correlates by Misra, Pinaki Pramathadhip, Kishore, Nand

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