Search Results - "Misono, Kunio S"

Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase by Misono, Kunio S, Philo, John S, Arakawa, Tsutomu, Ogata, Craig M, Qiu, Yue, Ogawa, Haruo, Young, Howard S

“…Atrial natriuretic peptide (ANP) and the homologous B-type natriuretic peptide are cardiac hormones that dilate blood vessels and stimulate natriuresis and…”
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Reversibly bound chloride in the atrial natriuretic peptide receptor hormone‐binding domain: Possible allosteric regulation and a conserved structural motif for the chloride‐binding site by Ogawa, Haruo, Qiu, Yue, Philo, John S., Arakawa, Tsutomu, Ogata, Craig M., Misono, Kunio S.

“…The binding of atrial natriuretic peptide (ANP) to its receptor requires chloride, and it is chloride concentration dependent. The extracellular domain (ECD)…”
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Structure of the dimerized hormone-binding domain of a guanylyl- cyclase-coupled receptor by Miyagi, Masaru, van den Akker, Focco, Zhang, Xiaolun, Yee, Vivien C, Huo, Xuewen, Misono, Kunio S

“…The atrial natriuretic peptide (ANP) hormone is secreted by the heart in response to an increase in blood pressure. ANP exhibits several potent…”
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Natriuretic peptides and their receptors by Misono, Kunio S.

“…Natriuretic peptides secreted by the heart play a major role in the regulation of cardiovascular homeostasis and remodeling. This minireview series discusses…”
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Ligand Binding-Dependent Limited Proteolysis of the Atrial Natriuretic Peptide Receptor:  Juxtamembrane Hinge Structure Essential for Transmembrane Signal Transduction by Huo, Xuewen, Abe, Tetsuaki, Misono, Kunio S

“…The atrial natriuretic peptide (ANP) receptor is a 130-kDa transmembrane protein containing an extracellular ANP-binding domain, a single transmembrane…”
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Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction by Ogawa, Haruo, Qiu, Yue, Ogata, Craig M, Misono, Kunio S

“…A cardiac hormone, atrial natriuretic peptide (ANP), plays a major role in blood pressure and volume regulation. ANP activities are mediated by a single span…”
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Natriuretic peptide receptor: structure and signaling by Misono, Kunio S

“…The ANP receptor is a single-transmembrane sequence receptor coupled to guanylate cyclase (GCase). It belongs to a family of GCase-coupled receptors that share…”
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Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy by Ogawa, Haruo, Qiu, Yue, Huang, Liming, Tam-Chang, Suk-Wah, Young, Howard S, Misono, Kunio S

“…Atrial natriuretic peptide (ANP) plays a major role in blood pressure and volume regulation. ANP activities are mediated by a cell surface, single-span…”
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Structural studies of the natriuretic peptide receptor: A novel hormone-induced rotation mechanism for transmembrane signal transduction by Misono, Kunio S., Ogawa, Haruo, Qiu, Yue, Ogata, Craig M.

“…The atrial natriuretic peptide (ANP) receptor is a single-span transmembrane receptor that is coupled to its intrinsic intracellular guanylate cyclase (GCase)…”
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Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence by Maki, Masatoshi, Takayanagi, Ryoichi, Misono, Kunio S, Pandey, Kailash N, Tibbetts, Clark, Inagami, Tadashi

“…The atrium of the heart contains peptides, termed atrial natriuretic factors ( ANFs ), diuretic and smooth-muscle-relaxing activities. In view of its potent…”
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Constitutive activation and uncoupling of the atrial natriuretic peptide receptor by mutations at the dimer interface. Role of the dimer structure in signalling by Qiu, Yue, Ogawa, Haruo, Miyagi, Masaru, Misono, Kunio S

“…The crystal packing of the extracellular hormone binding domain of the atrial natriuretic peptide (ANP) receptor contains two possible dimer pairs, the…”
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Atrial Natriuretic Factor Binding to Its Receptor Is Dependent on Chloride Concentration: A Possible Feedback-Control Mechanism in Renal Salt Regulation by Misono, Kunio S

“…Although considerable evidence indicates a role for atrial natriuretic factor (ANF) in renal salt regulation, other studies have found a lack of natriuretic…”
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Crystal Structure of Hormone-bound Atrial Natriuretic Peptide Receptor Extracellular Domain by Ogawa, Haruo, Qiu, Yue, Ogata, Craig M., Misono, Kunio S.

“…A cardiac hormone, atrial natriuretic peptide (ANP), plays a major role in blood pressure and volume regulation. ANP activities are mediated by a single span…”
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Constitutive Activation and Uncoupling of the Atrial Natriuretic Peptide Receptor by Mutations at the Dimer Interface by Qiu, Yue, Ogawa, Haruo, Miyagi, Masaru, Misono, Kunio S.

“…The crystal packing of the extracellular hormone binding domain of the atrial natriuretic peptide (ANP) receptor contains two possible dimer pairs, the…”
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Crystallization and preliminary X-ray analysis of the atrial natriuretic peptide (ANP) receptor extracellular domain complex with ANP: use of ammonium sulfate as the cryosalt by Ogawa, Haruo, Zhang, Xiaolun, Qiu, Yue, Ogata, Craig M., Misono, Kunio S.

“…Atrial natriuretic peptide (ANP) plays a major role in blood pressure and volume regulation owing to its natriuretic and vasodilatory activities. The ANP…”
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Expression and Purification of the Extracellular Ligand-Binding Domain of the Atrial Natriuretic Peptide (ANP) Receptor:  Monovalent Binding with ANP Induces 2:2 Complexes by Misono, Kunio S, Sivasubramanian, Natarajan, Berkner, Kathleen, Zhang, Xiaolun

“…The receptor for atrial natriuretic peptide (ANP) is a type-I transmembrane protein containing an extracellular ligand-binding domain, a single transmembrane…”
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Identification of the Vitamin K-Dependent Carboxylase Active Site: Cys-99 and Cys-450 Are Required for Both Epoxidation and Carboxylation by Pudota, B. Nirmala, Miyagi, Masaru, Hallgren, Kevin W., West, Karen A., Crabb, John W., Misono, Kunio S., Berkner, Kathleen L.

“…The vitamin K-dependent carboxylase modifies and renders active vitamin K-dependent proteins involved in hemostasis, cell growth control, and calcium…”
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Characterization of the active site of mouse submaxillary gland renin by Misono, Kunio S, Inagami, Tadashi

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Disulfide bond structure of the atrial natriuretic peptide receptor extracellular domain: conserved disulfide bonds among guanylate cyclase-coupled receptors by Miyagi, Masaru, Misono, Kunio S

“…The disulfide bond structure of the extracellular domain of rat atrial natriuretic peptide (ANP) receptor (NPR-ECD) has been determined by mass spectrometry…”
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High-Yield Affinity Alkylation of the Atrial Natriuretic Factor Receptor Binding Site by He, Xiaolan, Nishio, Koji, Misono, Kunio S

“…To facilitate characterization of the atrial natriuretic factor (ANF) receptor, we have developed an affinity labeling procedure, stepwise affinity labeling,…”
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