Search Results - "Miska, Jason"

Targeting fatty acid metabolism in glioblastoma by Miska, Jason, Chandel, Navdeep S

“…Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and resistance to conventional therapies. There have been considerable…”
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GLUT3 regulates alternative macrophage signaling through a glucose transport-independent role by Zhang, Peng, Miska, Jason, Heimberger, Amy B

“…Macrophages are key mediators of innate immunity whose functional state can be regulated by glucose transporters. Although abundantly expressed in macrophages,…”
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STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma by Zhang, Peng, Rashidi, Aida, Zhao, Junfei, Silvers, Caylee, Wang, Hanxiang, Castro, Brandyn, Ellingwood, Abby, Han, Yu, Lopez-Rosas, Aurora, Zannikou, Markella, Dmello, Crismita, Levine, Rebecca, Xiao, Ting, Cordero, Alex, Sonabend, Adam M., Balyasnikova, Irina V., Lee-Chang, Catalina, Miska, Jason, Lesniak, Maciej S.

“…As a key component of the standard of care for glioblastoma, radiotherapy induces several immune resistance mechanisms, such as upregulation of CD47 and PD-L1…”
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HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma by Miska, Jason, Lee-Chang, Catalina, Rashidi, Aida, Muroski, Megan E., Chang, Alan L., Lopez-Rosas, Aurora, Zhang, Peng, Panek, Wojciech K., Cordero, Alex, Han, Yu, Ahmed, Atique U., Chandel, Navdeep S., Lesniak, Maciej S.

“…The mechanisms by which regulatory T cells (Tregs) migrate to and function within the hypoxic tumor microenvironment are unclear. Our studies indicate that…”
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Editorial: Spatiotemporal heterogeneity in CNS tumors by Faisal, Syed M, Ravi, Vidhya M, Miska, Jason M

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FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis by Cordero, Alex, Kanojia, Deepak, Miska, Jason, Panek, Wojciech K., Xiao, Annie, Han, Yu, Bonamici, Nicolas, Zhou, Weidong, Xiao, Ting, Wu, Meijing, Ahmed, Atique U., Lesniak, Maciej S.

“…Overexpression of human epidermal growth factor receptor 2 (HER2) in breast cancer patients is associated with increased incidence of breast cancer brain…”
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Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity by Chia, Tzu-Yi, Zolp, Andrew, Miska, Jason

“…Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the…”
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Understanding the glioblastoma tumor microenvironment: leveraging the extracellular matrix to increase immunotherapy efficacy by Collado, Jimena, Boland, Lauren, Ahrendsen, Jared T, Miska, Jason, Lee-Chang, Catalina

“…Glioblastoma (GBM) accounts for approximately half of all malignant brain tumors, and it remains lethal with a five-year survival of less than 10%. Despite the…”
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Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis by Takata, Nozomu, Miska, Jason M., Morgan, Marc A., Patel, Priyam, Billingham, Leah K., Joshi, Neha, Schipma, Matthew J., Dumar, Zachary J., Joshi, Nikita R., Misharin, Alexander V., Embry, Ryan B., Fiore, Luciano, Gao, Peng, Diebold, Lauren P., McElroy, Gregory S., Shilatifard, Ali, Chandel, Navdeep S., Oliver, Guillermo

“…Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic metabolism in retinal morphogenesis remains unknown. We report that…”
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Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression by Khan, Fatima, Lin, Yiyun, Ali, Heba, Pang, Lizhi, Dunterman, Madeline, Hsu, Wen-Hao, Frenis, Katie, Grant Rowe, R., Wainwright, Derek A., McCortney, Kathleen, Billingham, Leah K., Miska, Jason, Horbinski, Craig, Lesniak, Maciej S., Chen, Peiwen

“…Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule…”
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Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas by Arrieta, Víctor A., Gould, Andrew, Kim, Kwang-Soo, Habashy, Karl J., Dmello, Crismita, Vázquez-Cervantes, Gustavo I., Palacín-Aliana, Irina, McManus, Graysen, Amidei, Christina, Gomez, Cristal, Dhiantravan, Silpol, Chen, Li, Zhang, Daniel Y., Saganty, Ruth, Cholak, Meghan E., Pandey, Surya, McCord, Matthew, McCortney, Kathleen, Castro, Brandyn, Ward, Rachel, Muzzio, Miguel, Bouchoux, Guillaume, Desseaux, Carole, Canney, Michael, Carpentier, Alexandre, Zhang, Bin, Miska, Jason M., Lesniak, Maciej S., Horbinski, Craig M., Lukas, Rimas V., Stupp, Roger, Lee-Chang, Catalina, Sonabend, Adam M.

“…Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we…”
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Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade by Dmello, Crismita, Zhao, Junfei, Chen, Li, Gould, Andrew, Castro, Brandyn, Arrieta, Victor A., Zhang, Daniel Y., Kim, Kwang-Soo, Kanojia, Deepak, Zhang, Peng, Miska, Jason, Yeeravalli, Ragini, Habashy, Karl, Saganty, Ruth, Kang, Seong Jae, Fares, Jawad, Liu, Connor, Dunn, Gavin, Bartom, Elizabeth, Schipma, Matthew J., Hsu, Patrick D., Alghamri, Mahmoud S., Lesniak, Maciej S., Heimberger, Amy B., Rabadan, Raul, Lee-Chang, Catalina, Sonabend, Adam M.

“…Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that…”
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A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress by Katz, Joshua L., Geng, Yuheng, Billingham, Leah K., Sadagopan, Nishanth S., DeLay, Susan L., Subbiah, Jay, Chia, Tzu-yi, McManus, Graysen, Wei, Chao, Wang, Hanxiang, Lin, Hanchen, Silvers, Caylee, Boland, Lauren K., Wang, Si, Wan, Hanxiao, Hou, David, Vázquez-Cervantes, Gustavo Ignacio, Arjmandi, Tarlan, Shaikh, Zainab H., Zhang, Peng, Ahmed, Atique U., Tiek, Deanna M., Lee-Chang, Catalina, Chouchani, Edward T., Miska, Jason

“…Glioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse infiltration, and near-uniform lethality. The underlying mechanisms are…”
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βIII-Tubulin Regulates Breast Cancer Metastases to the Brain by Kanojia, Deepak, Morshed, Ramin A, Zhang, Lingjiao, Miska, Jason M, Qiao, Jian, Kim, Julius W, Pytel, Peter, Balyasnikova, Irina V, Lesniak, Maciej S, Ahmed, Atique U

“…Brain metastases occur in about 10% to 30% of breast cancer patients, which culminates in a poor prognosis. It is, therefore, critical to understand the…”
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IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM by Zannikou, Markella, Duffy, Joseph T, Levine, Rebecca N, Seblani, Maggie, Liu, Qianli, Presser, Aaron, Arrieta, Victor A, Chen, Christopher J, Sonabend, Adam M, Horbinski, Craig M, Lee-Chang, Catalina, Miska, Jason, Lesniak, Maciej S, Gottschalk, Stephen, Balyasnikova, Irina V

“…IntroductionThe immunosuppressive tumor microenvironment (TME) is a major barrier to the efficacy of chimeric antigen receptor T cells (CAR-T cells) in…”
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Next Steps for Immunotherapy in Glioblastoma by Cao, Toni Q, Wainwright, Derek A, Lee-Chang, Catalina, Miska, Jason, Sonabend, Adam M, Heimberger, Amy B, Lukas, Rimas V

“…Outcomes for glioblastoma (GBM) patients undergoing standard of care treatment remain poor. Here we discuss the portfolio of previously investigated…”
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Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era by Larkin, Collin J., Arrieta, Víctor A., Najem, Hinda, Li, Gongbo, Zhang, Peng, Miska, Jason, Chen, Peiwen, James, Charles David, Sonabend, Adam M., Heimberger, Amy B.

“…The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved…”
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Fatty Acid Uptake in T Cell Subsets Using a Quantum Dot Fatty Acid Conjugate by Muroski, Megan E., Miska, Jason, Chang, Alan L., Zhang, Peng, Rashidi, Aida, Moore, Haley, Lopez-Rosas, Aurora, Han, Yu, Lesniak, Maciej S.

“…Fatty acid (FA) metabolism directly influences the functional capabilities of T cells in tumor microenvironments. Thus, developing tools to interrogate…”
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Antigen-presenting B cells promote TCF-1 + PD1 - stem-like CD8 + T-cell proliferation in glioblastoma by Hou, David, Wan, Hanxiao, Katz, Joshua L, Wang, Si, Castro, Brandyn A, Vazquez-Cervantes, Gustavo I, Arrieta, Victor A, Dhiantravan, Silpol, Najem, Hinda, Rashidi, Aida, Chia, Tzu-Yi, Arjmandi, Tarlan, Collado, Jimena, Billingham, Leah, Lopez-Rosas, Aurora, Han, Yu, Sonabend, Adam M, Heimberger, Amy B, Zhang, Peng, Miska, Jason, Lee-Chang, Catalina

“…Understanding the spatial relationship and functional interaction of immune cells in glioblastoma (GBM) is critical for developing new therapeutics that…”
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The CXCL16-CXCR6 axis in glioblastoma modulates T-cell activity in a spatiotemporal context by Chia, Tzu-Yi, Billingham, Leah K, Boland, Lauren, Katz, Joshua L, Arrieta, Victor A, Shireman, Jack, Rosas, Aurora-Lopez, DeLay, Susan L, Zillinger, Kaylee, Geng, Yuheng, Kruger, Jeandre, Silvers, Caylee, Wang, Hanxiang, Vazquez Cervantes, Gustavo Ignacio, Hou, David, Wang, Si, Wan, Hanxiao, Sonabend, Adam, Zhang, Peng, Lee-Chang, Catalina, Miska, Jason

“…Glioblastoma multiforme (GBM) pathobiology is characterized by its significant induction of immunosuppression within the tumor microenvironment, predominantly…”
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