Search Results - "Misiak, Alicja"

IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice by Misiak, Alicja, Wilk, Mieszko M, Raverdeau, Mathilde, Mills, Kingston H G

“…γδ T cells play a role in protective immunity to infection at mucosal surface, but also mediate pathology in certain autoimmune diseases through innate IL-17…”
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Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis by Wilk, Mieszko M, Misiak, Alicja, McManus, Róisín M, Allen, Aideen C, Lynch, Marina A, Mills, Kingston H G

“…Th1 and Th17 cells have an established role in protective immunity to , but this evidence is based largely on peripheral T cells. There is emerging evidence…”
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Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine by Ross, Pádraig J, Sutton, Caroline E, Higgins, Sarah, Allen, Aideen C, Walsh, Kevin, Misiak, Alicja, Lavelle, Ed C, McLoughlin, Rachel M, Mills, Kingston H G

“…Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One…”
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Caspase-11 promotes allergic airway inflammation by Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.

“…Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits…”
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Immunization with whole cell but not acellular pertussis vaccines primes CD4 TRM cells that sustain protective immunity against nasal colonization with Bordetella pertussis by Wilk, Mieszko M., Borkner, Lisa, Misiak, Alicja, Curham, Lucy, Allen, Aideen C., Mills, Kingston H. G.

“…Protective immunity wanes rapidly after immunization of children with acellular pertussis (aP) vaccines and these vaccines do not prevent nasal colonization or…”
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A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis , Including Pertactin Deficient Strains by Zurita, María Eugenia, Wilk, Mieszko M, Carriquiriborde, Francisco, Bartel, Erika, Moreno, Griselda, Misiak, Alicja, Mills, Kingston H G, Hozbor, Daniela

“…Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell…”
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A semi high-throughput whole blood-based flow cytometry assay to detect and monitor Bordetella pertussis -specific Th1, Th2 and Th17 responses by Corbière, Véronique, Lambert, Eleonora E, Rodesch, Marine, van Gaans-van den Brink, Jacqueline A M, Misiak, Alicja, Simonetti, Elles, Van Praet, Anne, Godefroid, Audrey, Diavatopoulos, Dimitri A, van Els, Cécile A C M, Mascart, Françoise

“…The characterization of (Bp) antigen-specific CD4 T cell cytokine responses should be included in the evaluation of immunogenicity of pertussis vaccines but is…”
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Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory by Borkner, Lisa, Misiak, Alicja, Wilk, Mieszko M, Mills, Kingston H G

“…Treatment with the macrolide antibiotic azithromycin (AZM) is an important intervention for controlling infection of children with and as a prophylaxis for…”
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Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T RM cells by Allen, Aideen C, Wilk, Mieszko M, Misiak, Alicja, Borkner, Lisa, Murphy, Dearbhla, Mills, Kingston H G

“…Current acellular pertussis (aP) vaccines induce strong antibody and Th2 responses but fail to protect against nasal colonization and transmission of…”
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Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells by Allen, Aideen C., Wilk, Mieszko M., Misiak, Alicja, Borkner, Lisa, Murphy, Dearbhla, Mills, Kingston H. G.

“…Current acellular pertussis (aP) vaccines induce strong antibody and Th2 responses but fail to protect against nasal colonization and transmission of…”
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Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation by Mielke, Lisa A, Jones, Sarah A, Raverdeau, Mathilde, Higgs, Rowan, Stefanska, Anna, Groom, Joanna R, Misiak, Alicja, Dungan, Lara S, Sutton, Caroline E, Streubel, Gundula, Bracken, Adrian P, Mills, Kingston H G

“…Retinoic acid (RA), a vitamin A metabolite, modulates mucosal T helper cell responses. Here we examined the role of RA in regulating IL-22 production by γδ T…”
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Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model by Dyck, Lydia, Wilk, Mieszko M., Raverdeau, Mathilde, Misiak, Alicja, Boon, Louis, Mills, Kingston H. G.

“…The co-inhibitory molecule PD-1 suppresses T cell responses and has been targeted in the treatment of cancer. Here, we examined the role of PD-1 in regulating…”
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Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model by Misiak, Alicja, Leuzzi, Rosanna, Allen, Aideen C., Galletti, Bruno, Baudner, Barbara C., D'Oro, Ugo, O'Hagan, Derek T., Pizza, Mariagrazia, Seubert, Anja, Mills, Kingston H.G.

“…•Adresses protection of adjuvanted acellular pertussis vaccines in the mouse model.•Alum-TLR7a adjuvant induces Th1/Th17 profile and higher IgG2a/b…”
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Retinoic acid suppresses IL‐17 production and pathogenic activity of γδ T cells in CNS autoimmunity by Raverdeau, Mathilde, Breen, Conor J, Misiak, Alicja, Mills, Kingston HG

“…Retinoic acid (RA) in the steady state enhances induction of Foxp3+ regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby…”
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Retinoic acid‐induced autoantigen‐specific type 1 regulatory T cells suppress autoimmunity by Raverdeau, Mathilde, Christofi, Maria, Malara, Anna, Wilk, Mieszko M, Misiak, Alicja, Kuffova, Lucia, Yu, Tian, McGinley, Aoife M, Quinn, Shauna M, Massilamany, Chandirasegaran, Reddy, Jay, Forrester, John V, Mills, Kingston HG

“…Regulatory T (Treg) cells help to maintain tolerance and prevent the development of autoimmune diseases. Retinoic acid (RA) can promote peripheral conversion…”
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Retinoic acid suppresses IL-17 production and pathogenic activity of [gamma][delta] T cells in CNS autoimmunity by Raverdeau, Mathilde, Breen, Conor J, Misiak, Alicja, Mills, Kingston Hg

“…Retinoic acid (RA) in the steady state enhances induction of Foxp3+ regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby…”
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IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory gamma delta T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice by Misiak, Alicja, Wilk, Mieszko M, Raverdeau, Mathilde, Mills, Kingston HG

“…gamma delta T cells play a role in protective immunity to infection at mucosal surface, but also mediate pathology in certain autoimmune diseases through…”
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Anti-PD-1 inhibits Foxp3^sup +^ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model by Dyck, Lydia, Wilk, Mieszko M, Raverdeau, Mathilde, Misiak, Alicja, Boon, Louis, Mills, Kingston H; G

“…The co-inhibitory molecule PD-1 suppresses T cell responses and has been targeted in the treatment of cancer. Here, we examined the role of PD-1 in regulating…”
Get full text

Anti-PD-1 inhibits Foxp3 super(+) Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model by Dyck, Lydia, Wilk, Mieszko M, Raverdeau, Mathilde, Misiak, Alicja, Boon, Louis, Mills, Kingston HG

“…The co-inhibitory molecule PD-1 suppresses T cell responses and has been targeted in the treatment of cancer. Here, we examined the role of PD-1 in regulating…”
Get full text

Retinoic acid suppresses IL-17 production and pathogenic activity of gamma delta T cells in CNS autoimmunity by Raverdeau, Mathilde, Breen, Conor J, Misiak, Alicja, Mills, Kingston HG

“…Retinoic acid (RA) in the steady state enhances induction of Foxp3 super(+) regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells,…”
Get full text