Search Results - "Mishto, M."

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes by Ebstein, F., Textoris-Taube, K., Keller, C., Golnik, R., Vigneron, N., Van den Eynde, B. J., Schuler-Thurner, B., Schadendorf, D., Lorenz, F. K. M., Uckert, W., Urban, S., Lehmann, A., Albrecht-Koepke, N., Janek, K., Henklein, P., Niewienda, A., Kloetzel, P. M., Mishto, M.

“…Proteasome-catalyzed peptide splicing represents an additional catalytic activity of proteasomes contributing to the pool of MHC-class I-presented epitopes. We…”
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Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies by Cevenini, E, Bellavista, E, Tieri, P, Castellani, G, Lescai, F, Francesconi, M, Mishto, M, Santoro, A, Valensin, S, Salvioli, S, Capri, M, Zaikin, A, Monti, D, de Magalhães, J P, Franceschi, C

“…Human aging and longevity are complex and multi-factorial traits that result from a combination of environmental, genetic, epigenetic and stochastic factors,…”
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Association of p53 polymorphisms and colorectal cancer: Modulation of risk and progression by Mammano, E, Belluco, C, Bonafé, M, Olivieri, F, Mugianesi, E, Barbi, C, Mishto, M, Cosci, M, Franceschi, C, Lise, M, Nitti, D

“…Abstract Objectives p53 Gene variants BstUI RFLP at codon 72 in exon 4, 16 bp tandem repeat in intron 3 and MspI RFLP in intron 6, which code for two…”
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Genes, ageing and longevity in humans: problems, advantages and perspectives by Salvioli, S, Olivieri, F, Marchegiani, F, Cardelli, M, Santoro, A, Bellavista, E, Mishto, M, Invidia, L, Capri, M, Valensin, S, Sevini, F, Cevenini, E, Celani, L, Lescai, F, Gonos, E, Caruso, C, Paolisso, G, De Benedictis, G, Monti, D, Franceschi, C

“…Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible…”
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The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death by Bonafé, M, Salvioli, S, Barbi, C, Trapassi, C, Tocco, F, Storci, G, Invidia, L, Vannini, I, Rossi, M, Marzi, E, Mishto, M, Capri, M, Olivieri, F, Antonicelli, R, Memo, M, Uberti, D, Nacmias, B, Sorbi, S, Monti, D, Franceschi, C

“…A common arginine to proline polymorphism is harboured at codon 72 of the human p53 gene. In this investigation, we found that fibroblasts and lymphocytes…”
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Age dependent impact of LMP polymorphisms on TNFα-induced apoptosis in human peripheral blood mononuclear cells by Mishto, M., Bonafè, M., Salvioli, S., Olivieri, F., Franceschi, C.

“…As a consequence of inflammatory stimuli (such as TNFα and IFNγ), some constitutive subunits of the proteasome, the principal mediator of nonlysosomal protein…”
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Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains by Mishto, Michele, Bellavista, Elena, Santoro, Aurelia, Stolzing, Alexandra, Ligorio, Claudia, Nacmias, Benedetta, Spazzafumo, Liana, Chiappelli, Martina, Licastro, Federico, Sorbi, Sandro, Pession, Annalisa, Ohm, Thomas, Grune, Tilman, Franceschi, Claudio

“…In this study, we investigated the presence and role of immunoproteasome and its LMP2 subunit polymorphism at codon 60 in Alzheimer's disease (AD)…”
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Immunoproteasome in cancer and neuropathologies: a new therapeutic target? by Bellavista, Elena, Andreoli, Federico, Parenti, Marco Daniele, Martucci, Morena, Santoro, Aurelia, Salvioli, Stefano, Capri, Miriam, Baruzzi, Agostino, Del Rio, Alberto, Franceschi, Claudio, Mishto, Michele

“…Immunoproteasome is an emerging biological target that constitutes a key element not only in antigen presentation but also in T cell and cytokine regulation as…”
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Immunoproteasomes and immunosenescence by Mishto, Michele, Santoro, Aurelia, Bellavista, Elena, Bonafé, Massimiliano, Monti, Daniela, Franceschi, Claudio

“…Aging is a complex process which is accompanied with the decline and the reshaping of different functions of the body. In particular the immune system is…”
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A Mathematical Model of Protein Degradation by the Proteasome by Luciani, Fabio, Keşmir, Can, Mishto, Michele, Or-Guil, Michal, de Boer, Rob J.

“…The proteasome is the major protease for intracellular protein degradation. The influx rate of protein substrates and the exit rate of the fragments/products…”
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Modeling the in Vitro 20S Proteasome Activity: The Effect of PA28-^a^b and of the Sequence and Length of Polypeptides on the Degradation Kinetics by Mishto, M, Luciani, F, Holzhutter, H G, Bellavista, E, Santoro, A, Textoris-Taube, K, Franceschi, C, Kloetzel, P M, Zaikin, A

“…Proteasomes are fundamental for the degradation of intracellular proteins, having a key role in several important metabolic and signaling pathways, in the cell…”
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A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms by Mishto, Michele, Santoro, Aurelia, Bellavista, Elena, Sessions, Richard, Textoris-Taube, Kathrin, Dal Piaz, Fabrizio, Carrard, Geraldine, Forti, Katia, Salvioli, Stefano, Friguet, Bertrand, Kloetzel, Peter M, Rivett, A Jennifer, Franceschi, Claudio

“…The immunoproteasome subunit low molecular weight protein 2 (LMP2) codon 60 polymorphism has been associated with autoimmune diseases. It has also been…”
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p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes by Bonafè, Massimiliano, Salvioli, Stefano, Barbi, Cristiana, Mishto, Michele, Trapassi, Chiara, Gemelli, Claudia, Storci, Gianluca, Olivieri, Fabiola, Monti, Daniela, Franceschi, Claudio

“…A wide difference in the susceptibility to undergo in vitro apoptosis exists among individuals, and this fact has potential implications in predicting the in…”
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Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells by Mishto, M, Bonafè, M, Salvioli, S, Olivieri, F, Franceschi, C

“…As a consequence of inflammatory stimuli (such as TNFalpha and IFNgamma), some constitutive subunits of the proteasome, the principal mediator of nonlysosomal…”
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Reverse Engineering of Proteasomal Translocation Rates by Goldobin, D. S, Mishto, M, Textoris-Taube, K, Kloetzel, P. M, Zaikin, A

“…We address the problem of proteasomal protein translocation and introduce a new stochastic model of the proteasomal digestion (cleavage) of proteins. In this…”
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