Search Results - "Mishra, Ribhav"

LISTERIN E3 Ubiquitin Ligase and Ribosome-Associated Quality Control (RQC) Mechanism by Mishra, Ribhav, Bansal, Anurag, Mishra, Amit

“…According to cellular demands, ribosomes synthesize and maintain the desired pool of proteins inside the cell. However, sometimes due to defects in ribosomal…”
Get full text

Discovery of a potent small molecule inhibiting Huntington’s disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein by Khan, Eshan, Mishra, Subodh Kumar, Mishra, Ribhav, Mishra, Amit, Kumar, Amit

“…CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington’s disease (HD) and several spinocerebellar ataxias (SCAs). Although…”
Get full text

E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration by Upadhyay, Arun, Joshi, Vibhuti, Amanullah, Ayeman, Mishra, Ribhav, Arora, Naina, Prasad, Amit, Mishra, Amit

“…Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to…”
Get full text

A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging? by Joshi, Vibhuti, Amanullah, Ayeman, Upadhyay, Arun, Mishra, Ribhav, Kumar, Amit, Mishra, Amit

“…Cells regularly synthesize new proteins to replace old and abnormal proteins for normal cellular functions. Two significant protein quality control pathways…”
Get full text

Resveratrol Promotes LRSAM1 E3 Ubiquitin Ligase-Dependent Degradation of Misfolded Proteins Linked with Neurodegeneration by Dubey, Ankur Rakesh, Mishra, Ribhav, Sundaria, Naveen, Jagtap, Yuvraj Anandrao, Kumar, Prashant, Kinger, Sumit, Choudhary, Akash, Jha, Hem Chandra, Prasad, Amit, Gutti, Ravi Kumar, Mishra, Amit

“…BACKGROUND/AIMS: Cells require regular maintenance of proteostasis. Synthesis of new polypeptides and elimination of damaged or old proteins is an…”
Get full text

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model by Chhangani, Deepak, Endo, Fumito, Amanullah, Ayeman, Upadhyay, Arun, Watanabe, Seiji, Mishra, Ribhav, Yamanaka, Koji, Mishra, Amit

“…Abstract Proteotoxicity of misfolded, disease-causing proteins is deeply implicated in the pathomechanisms for neurodegenerative diseases including copper-zinc…”
Get full text

Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases by Mishra, Ribhav, Upadhyay, Arun, Prajapati, Vijay Kumar, Mishra, Amit

“…Proteins actively participate in a wide range of cellular physiological functions. But aggregation of proteins results in cytotoxicity, and unwanted…”
Get full text

Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation by Joshi, Vibhuti, Mishra, Ribhav, Upadhyay, Arun, Amanullah, Ayeman, Poluri, Krishna Mohan, Singh, Sarika, Kumar, Amit, Mishra, Amit

“…Major neurodegenerative disorders are characterized by the formation of misfolded proteins aggregates inside or outside the neuronal cells. Previous studies…”
Get full text

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration by Amanullah, Ayeman, Upadhyay, Arun, Joshi, Vibhuti, Mishra, Ribhav, Jana, Nihar Ranjan, Mishra, Amit

“…Proteins are ordered useful cellular entities, required for normal health and organism's survival. The proteome is the absolute set of cellular expressed…”
Get full text

Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases by Upadhyay, Arun, Amanullah, Ayeman, Mishra, Ribhav, Kumar, Amit, Mishra, Amit

“…Accumulation of misfolded or aberrant proteins in neuronal cells is linked with neurodegeneration and other pathologies. Which molecular mechanisms fail and…”
Get full text

Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's disease (HD) and spinocerebellar ataxia (SCAs) by Khan, Eshan, Biswas, Soumen, Mishra, Subodh Kumar, Mishra, Ribhav, Samanta, Sampak, Mishra, Amit, Tawani, Arpita, Kumar, Amit

“…Huntington's diseases (HD) is a very devastating disease caused by r(CAG) expansion in HTT gene, encoding the huntingtin protein. r(CAG) expansion causes…”
Get full text

LRSAM1 E3 ubiquitin ligase: molecular neurobiological perspectives linked with brain diseases by Mishra, Ribhav, Upadhyay, Arun, Prajapati, Vijay Kumar, Dhiman, Rohan, Poluri, Krishna Mohan, Jana, Nihar Ranjan, Mishra, Amit

“…Cellular protein quality control (PQC) plays a significant role in the maintenance of cellular homeostasis. Failure of PQC mechanism may lead to various…”
Get full text

Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death by Mishra, Ribhav, Amanullah, Ayeman, Upadhyay, Arun, Dhiman, Rohan, Dubey, Ankur Rakesh, Singh, Sarika, Prasad, Amit, Mishra, Amit

“…[Display omitted] •LRSAM1 can function as a quality control E3 Ubiquitin Ligase.•Recruitment of LRSAM1 towards misfolded proteins.•LRSAM1 levels induced under…”
Get full text

Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Mishra, Ribhav, Mishra, Amit

“…Graphical abstract The theme of “Balancing Acts of Selective Defenders: Emerging Multifaceted E3 Ubiquitin Ligases Determine Precision of Cellular fitness and…”
Get full text

Itraconazole Confers Cytoprotection Against Neurodegenerative Disease-Associated Abnormal Protein Aggregation by Dubey, Ankur Rakesh, Mishra, Ribhav, Jagtap, Yuvraj Anandrao, Kinger, Sumit, Kumar, Prashant, Dhiman, Rohan, Ghosh, Somnath, Singh, Sarika, Prasad, Amit, Jana, Nihar Ranjan, Mishra, Amit

“…Cells perform regular maintenance to avoid the accumulation of misfolded proteins. Prolonged accumulation of these proteotoxic inclusions generates potential…”
Get full text

Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities by Amanullah, Ayeman, Mishra, Ribhav, Upadhyay, Arun, Reddy, Pothula P., Das, Ranabir, Mishra, Amit

“…Non‐steroidal anti‐inflammatory drugs (NSAIDs) are a class of drugs that are mainly used to treat pain, inflammation, and fever via cyclooxygenase‐2 (COX‐2)…”
Get full text

Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Joshi, Vibhuti, Mishra, Ribhav, Mishra, Amit

“…In routine course of life, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed antipyretic, analgesic, and anti-inflammatory drugs. It is a…”
Get full text

Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Mishra, Ribhav, Prasad, Amit, Mishra, Amit

“…In healthy cell, inappropriate accumulation of poor or damaged proteins is prevented by cellular quality control system. Autophagy and ubiquitin proteasome…”
Get full text

LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein by Mishra, Ribhav, Joshi, Vibhuti, Upadhyay, Arun, Amanullah, Ayeman, Dubey, Ankur Rakesh, Singh, Sarika, Dubey, Vikash Kumar, Poluri, Krishna Mohan, Jana, Nihar Ranjan, Mishra, Amit

“…Numerous proteins participate and actively contribute to the various cellular mechanisms, where several of them are crucial for regular metabolism, including…”
Get full text

Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway by Amanullah, Ayeman, Upadhyay, Arun, Chhangani, Deepak, Joshi, Vibhuti, Mishra, Ribhav, Yamanaka, Koji, Mishra, Amit

“…ABSTRACT Diclofenac is the most commonly used phenylacetic acid derivative non‐steroidal anti‐inflammatory drug (NSAID) that demonstrates significant…”
Get full text