Search Results - "Mishra, Lopa"

EMT, CTCs and CSCs in tumor relapse and drug-resistance by Mitra, Abhisek, Mishra, Lopa, Li, Shulin

“…Tumor relapse and metastasis are the primary causes of poor survival rates in patients with advanced cancer despite successful resection or chemotherapeutic…”
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Technologies for deriving primary tumor cells for use in personalized cancer therapy by Mitra, Abhisek, Mishra, Lopa, Li, Shulin

“…Highlights • Immortalized cancer cell lines cannot meet the needs of personalized medicine. • Primary cells from solid tumors are important in personalized…”
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Cell‐surface Vimentin: A mislocalized protein for isolating csVimentin+CD133− novel stem‐like hepatocellular carcinoma cells expressing EMT markers by Mitra, Abhisek, Satelli, Arun, Xia, Xueqing, Cutrera, Jeffrey, Mishra, Lopa, Li, Shulin

“…Recent advances in cancer stem cell biology have shown that cancer stem‐like cells with epithelial–mesenchymal transition (EMT) phenotypes are more aggressive…”
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IL6‐mediated inflammatory loop reprograms normal to epithelial‐mesenchymal transition+ metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta–deficient β2‐spectrin+/− mice by Mitra, Abhisek, Yan, Jun, Xia, Xueqing, Zhou, Shouhao, Chen, Jian, Mishra, Lopa, Li, Shulin

“…Hepatocellular carcinoma (HCC) is the second‐leading cause of cancer‐related deaths worldwide with a poor survival rate. As many as 40% of HCCs are clonal,…”
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Baseline human gut microbiota profile in healthy people and standard reporting template by King, Charles H, Desai, Hiral, Sylvetsky, Allison C, LoTempio, Jonathan, Ayanyan, Shant, Carrie, Jill, Crandall, Keith A, Fochtman, Brian C, Gasparyan, Lusine, Gulzar, Naila, Howell, Paul, Issa, Najy, Krampis, Konstantinos, Mishra, Lopa, Morizono, Hiroki, Pisegna, Joseph R, Rao, Shuyun, Ren, Yao, Simonyan, Vahan, Smith, Krista, VedBrat, Sharanjit, Yao, Michael D, Mazumder, Raja

“…A comprehensive knowledge of the types and ratios of microbes that inhabit the healthy human gut is necessary before any kind of pre-clinical or clinical study…”
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Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications by Churi, Chaitanya R, Shroff, Rachna, Wang, Ying, Rashid, Asif, Kang, HyunSeon C, Weatherly, Jacqueline, Zuo, Mingxin, Zinner, Ralph, Hong, David, Meric-Bernstam, Funda, Janku, Filip, Crane, Christopher H, Mishra, Lopa, Vauthey, Jean-Nicholas, Wolff, Robert A, Mills, Gordon, Javle, Milind

“…Cholangiocarcinoma (CCA) is clinically heterogeneous; intra and extrahepatic CCA have diverse clinical presentations. Next generation sequencing (NGS)…”
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Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein–Receptor–Related Proteins 5 and 6 by Lai, Keane K.Y, Kweon, Soo-Mi, Chi, Feng, Hwang, Edward, Kabe, Yasuaki, Higashiyama, Reiichi, Qin, Lan, Yan, Rui, Wu, Raymond P, Fujii, Naoaki, French, Samuel, Xu, Jun, Wang, Jian-Ying, Murali, Ramanchadran, Mishra, Lopa, Lee, Ju-Seog, Ntambi, James M, Tsukamoto, Hidekazu

“…Background & Aims Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty acids (MUFAs) and has been associated with the development of metabolic…”
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IL‐30 (IL27p28) attenuates liver fibrosis through inducing NKG2D‐rae1 interaction between NKT and activated hepatic stellate cells in mice by Mitra, Abhisek, Satelli, Arun, Yan, Jun, Xueqing, Xia, Gagea, Mihai, Hunter, Christopher A., Mishra, Lopa, Li, Shulin

“…Chronic hepatic diseases, such as cirrhosis, hepatocellular carcinoma, and virus‐mediated immunopathogenic infections, affect billions of people worldwide…”
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Regulatory T cell: a double-edged sword from metabolic-dysfunction-associated steatohepatitis to hepatocellular carcinoma by Wang, Han, Tsung, Allan, Mishra, Lopa, Huang, Hai

“…Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming a leading cause of end-stage liver disease globally…”
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Cancer stem cells and hepatocellular carcinoma by Yao, Zhixing, Mishra, Lopa

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, with a median survival of 6 to 16 months. Factors responsible for the poor prognosis…”
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Global and targeted serum metabolic profiling of colorectal cancer progression by Long, Yin, Sanchez‐Espiridion, Beatriz, Lin, Moubin, White, Lindsey, Mishra, Lopa, Raju, Gottumakkala S., Kopetz, Scott, Eng, Cathy, Hildebrandt, Michelle A. T., Chang, David W., Ye, Yuanqing, Liang, Dong, Wu, Xifeng

“…BACKGROUND Patients with colorectal adenoma polyps (PLPs) are at higher risk for developing colorectal cancer (CRC). However, the development of improved and…”
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HER2/neu-directed therapy for biliary tract cancer by Javle, Milind, Churi, Chaitanya, Kang, HyunSeon C, Shroff, Rachna, Janku, Filip, Surapaneni, Rakesh, Zuo, Mingxin, Barrera, Christian, Alshamsi, Humaid, Krishnan, Sunil, Mishra, Lopa, Wolff, Robert A, Kaseb, Ahmed O, Thomas, Melanie B, Siegel, Abby B

“…Biliary cancers are highly aggressive tumors that are often diagnosed an advanced disease stage and have a poor outcome with systemic therapy. Recent efforts…”
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Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose by Bloom, Joshua, Pantouris, Georgios, He, Mingzhu, Aljabari, Bayan, Mishra, Lopa, Manjula, Ramu, Parkins, Andrew, Lolis, Elias J, Al-Abed, Yousef

“…Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases,…”
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The somatic mutation landscape of premalignant colorectal adenoma by Lin, Shu-Hong, Raju, Gottumukkala S, Huff, Chad, Ye, Yuanqing, Gu, Jian, Chen, Jiun-Sheng, Hildebrandt, Michelle A T, Liang, Han, Menter, David G, Morris, Jeffery, Hawk, Ernest, Stroehlein, John R, Futreal, Andrew, Kopetz, Scott, Mishra, Lopa, Wu, Xifeng

“…There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma…”
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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression by Wang, Rui-Hong, Li, Cuiling, Xu, Xiaoling, Zheng, Yin, Xiao, Cuiying, Zerfas, Patricia, Cooperman, Sharon, Eckhaus, Michael, Rouault, Tracey, Mishra, Lopa, Deng, Chu-Xia

“…Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the most common genetic disorders among Caucasians. Hepcidin, which is…”
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Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review by Lominadze, Zurabi, Hill, Kareen, Shaik, Mohammed Rifat, Canakis, Justin P, Bourmaf, Mohammad, Adams-Mardi, Cyrus, Abutaleb, Ameer, Mishra, Lopa, Shetty, Kirti

“…The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions…”
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Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis by Thompson, Dane A, Tsaava, Tea, Rishi, Arvind, Nadella, Sandeep, Mishra, Lopa, Tuveson, David A, Pavlov, Valentin A, Brines, Michael, Tracey, Kevin J, Chavan, Sangeeta S

“…Inflammation is an inherently self-amplifying process, resulting in progressive tissue damage when unresolved. A brake on this positive feedback system is…”
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Progenitor/Stem Cells Give Rise to Liver Cancer Due to Aberrant TGF-β and IL-6 Signaling by Tang, Yi, Kitisin, Krit, Jogunoori, Wilma, Li, Cuiling, Deng, Chu-Xia, Mueller, Susette C., Ressom, Habtom W., Rashid, Asif, He, Aiwu Ruth, Mendelson, Jonathan S., Jessup, John M., Shetty, Kirti, Zasloff, Michael, Mishra, Bibhuti, Reddy, E. P., Johnson, Lynt, Mishra, Lopa

“…Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet functional interactions between…”
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Poly-ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis by Zhou, Xin, PhD, Patel, Darshan, BS, Sen, Sabyasachi, MD, Shanmugam, Victoria, MD, Sidawy, Anton, MD, MPH, Mishra, Lopa, MD, Nguyen, Bao-Ngoc, MD

“…Objective Chronic nonhealing wounds are a major health problem for patients in the United States and worldwide. Diabetes and ischemia are two major risk…”
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Identification of microRNAs specifically expressed in hepatitis C virus‐associated hepatocellular carcinoma by Diaz, Giacomo, Melis, Marta, Tice, Ashley, Kleiner, David E., Mishra, Lopa, Zamboni, Fausto, Farci, Patrizia

“…Although several studies have investigated the association of miRNAs with hepatocellular carcinoma (HCC), the data published so far are not concordant. A…”
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