Search Results - "Mishra, Hemant K"

Revolutionizing Cancer Treatments through Stem Cell-Derived CAR T Cells for Immunotherapy: Opening New Horizons for the Future of Oncology by Mishra, Hemant K, Kalyuzhny, Alex

“…Recent advances in cellular therapies have paved the way for innovative treatments of various cancers and autoimmune disorders. Induced pluripotent stem cells…”
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Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis by Mishra, Hemant K, Ma, Jing, Walcheck, Bruce

“…Neutrophils are specialized at killing bacteria and are recruited from the blood in a rapid and robust manner during infection. A cascade of adhesion events…”
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Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation by Mishra, Hemant K, Dixon, Kate J, Pore, Nabendu, Felices, Martin, Miller, Jeffrey S, Walcheck, Bruce

“…Natural killer (NK) cells are innate cytotoxic lymphocytes that can recognize assorted determinants on tumor cells and rapidly kill these cells. Due to their…”
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Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis by Mishra, Hemant K, Ma, Jing, Mendez, Daniel, Hullsiek, Robert, Pore, Nabendu, Walcheck, Bruce

“…Sepsis is the culmination of hyperinflammation and immune suppression in response to severe infection. Neutrophils are critical early responders to bacterial…”
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Expression of a Recombinant High Affinity IgG Fc Receptor by Engineered NK Cells as a Docking Platform for Therapeutic mAbs to Target Cancer Cells by Snyder, Kristin M, Hullsiek, Robert, Mishra, Hemant K, Mendez, Daniel C, Li, Yunfang, Rogich, Allison, Kaufman, Dan S, Wu, Jianming, Walcheck, Bruce

“…Anti-tumor mAbs are the most widely used and characterized cancer immunotherapy. Despite having a significant impact on some malignancies, most cancer patients…”
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Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy by Wu, Jianming, Mishra, Hemant K, Walcheck, Bruce

“…Human NK cell antitumor activities involve Ab‐dependent cell‐mediated cytotoxicity (ADCC), which is a key mechanism of action for several clinically successful…”
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Prevalence and risk factors of obstructive sleep apnea among middle-aged urban Indians: A community-based study by Reddy, Emmadi V, Kadhiravan, Tamilarasu, Mishra, Hemant K, Sreenivas, Vishnubhatla, Handa, Kumud K, Sinha, Sanjeev, Sharma, Surendra K

“…Abstract Background The epidemiology of obstructive sleep apnea (OSA) and obstructive sleep apnea syndrome (OSAS) is not well studied among Indians. We sought…”
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Clinical Applications of Flow Cytometry in Cancer Immunotherapies: From Diagnosis to Treatments by Mishra, Hemant K

“…The scope of flow cytometry is rapidly expanding in the diagnosis of various cancers, and it is being used routinely as an aid in classifying leukemias and…”
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Interleukin-15 in autoimmunity by Allard-Chamard, Hugues, Mishra, Hemant K., Nandi, Madhuparna, Mayhue, Marian, Menendez, Alfredo, Ilangumaran, Subburaj, Ramanathan, Sheela

“…•IL-15 in implicated in various autoimmune diseases.•IL-15 is a potential immunotherapeutic target in autoimmunity.•Biologics targeting IL-15 or its receptors…”
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Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells by Mishra, Hemant K., Pore, Nabendu, Michelotti, Emil F., Walcheck, Bruce

“…Several clinically successful tumor-targeting mAbs induce NK cell effector functions. Human NK cells exclusively recognize tumor-bound IgG by the FcR CD16A…”
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On the optimal error exponents for classical and quantum antidistinguishability by Mishra, Hemant K., Nussbaum, Michael, Wilde, Mark M.

“…The concept of antidistinguishability of quantum states has been studied to investigate foundational questions in quantum mechanics. It is also called quantum…”
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Regulation of CXCR2 expression and function by a disintegrin and metalloprotease‐17 (ADAM17) by Mishra, Hemant K., Long, Chunmei, Bahaie, Nooshin S., Walcheck, Bruce

“…ADAM17 regulates CXCR2 surface levels in circulating neutrophils and their infiltration into sites of inflammation. The chemokine receptor CXCR2 is expressed…”
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Targeting ADAM17 in leukocytes increases neutrophil recruitment and reduces bacterial spread during polymicrobial sepsis by Mishra, Hemant K, Johnson, Timothy J., Seelig, Davis M., Walcheck, Bruce

“…ADAM17 activity in leukocytes during sepsis tips the balance between efficient and impaired neutrophil migration into sites of infection. A rapid and robust…”
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Corticosteroid therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials by Pulakurthi, Yashwitha Sai, Pederson, John M., Saravu, Kavitha, Gupta, Nitin, Balasubramanian, Prasanth, Kamrowski, Shelby, Schmidt, Megan, Vegivinti, Charan Thej Reddy, Dibas, Mahmoud, Reierson, Natalie L., Pisipati, Sailaja, Joseph, Betsy Ann, Selvan, Pragadeesh Thamarai, Dmytriw, Adam A., Keesari, Praneeth Reddy, Sriram, Varsha, Chittajallu, Spandana, Brinjikji, Waleed, Katamreddy, Rewanth R., Chibbar, Richa, Davis, Amber R., Malpe, Manashree, Mishra, Hemant K., Kallmes, Kevin M., Hassan, Ameer E., Evanson, Kirk W.

“…Corticosteroid treatment is an effective and common therapeutic strategy for various inflammatory lung pathologies and may be an effective treatment for…”
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The effect of natural matrix biopolymer membrane on hard-to-heal venous leg ulcers: a pilot randomised clinical trial by Atias, Ziva, Pederson, John M, Mishra, Hemant K, Greenberger, Shoshana

“…Objective: The aim of this study was to evaluate the therapeutic effects of natural matrix biopolymer membrane (NMBM) in the treatment of venous leg ulcers…”
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Efficacy of convalescent plasma therapy for COVID‐19: A systematic review and meta‐analysis by Vegivinti, Charan T. R., Pederson, John M., Saravu, Kavitha, Gupta, Nitin, Evanson, Kirk W., Kamrowski, Shelby, Schmidt, Megan, Barrett, Averi, Trent, Hannah, Dibas, Mahmoud, Reierson, Natalie L., Mikoff, Nick, Pisipati, Sailaja, Joseph, Betsy A., Selvan, Pragadeesh T., Dmytriw, Adam A., Pulakurthi, Yashwitha S., Keesari, Praneeth R., Sriram, Varsha, Chittajallu, Spandana, Brinjikji, Waleed, Katamreddy, Rewanth R., Chibbar, Richa, Davis, Amber R., Malpe, Manashree, Mishra, Hemant K., Kallmes, Kevin M., Hassan, Ameer E.

“…The purpose of this systematic review and meta‐analysis was to examine clinical outcomes associated with convalescent plasma therapy in COVID‐19 patients. We…”
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Prevalence of extensively drug-resistant tuberculosis among patients with multidrug-resistant tuberculosis: a retrospective hospital-based study by Sharma, Surendra K, George, Ninoo, Kadhiravan, Tamilarasu, Saha, Pradip K, Mishra, Hemant K, Hanif, Mahmud

“…Extensively drug-resistant tuberculosis (XDR-TB) is a difficult-to-treat form of multidrug-resistant tuberculosis (MDR-TB). High rates of XDR-TB have been…”
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Prevalence and risk factors of syndrome Z in urban Indians by Sharma, Surendra K, Reddy, Emmadi V, Sharma, Abhishek, Kadhiravan, Tamilarasu, Mishra, Hridesh K, Sreenivas, Vishnubhatla, Mishra, Hemant K, Lakshmy, Ramakrishnan

“…Abstract Background Syndrome Z is defined as the co-occurrence of obstructive sleep apnea (OSA) and metabolic syndrome. There is a paucity of information on…”
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Stepped approach for prediction of syndrome Z in patients attending sleep clinic: a north Indian hospital-based study by Agrawal, Swastik, Sharma, Surendra Kumar, Sreenivas, Vishnubhatla, Lakshmy, Ramakrishnan, Mishra, Hemant K.

“…Purpose Syndrome Z is the occurrence of metabolic syndrome (MS) with obstructive sleep apnea. Knowledge of its risk factors is useful to screen patients…”
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Majorization in some symplectic weak supermajorizations by Huang, Shaowu, Mishra, Hemant K.

“…Symplectic eigenvalues are known to satisfy analogs of several classic eigenvalue inequalities. Of these is a set of weak supermajorization relations…”
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