Search Results - "Mishra, Arjun K"

Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing by Mishra, Arjun K, Mariuzza, Roy A

“…Affinity maturation is the process whereby the immune system generates antibodies of higher affinities during a response to antigen. It is unique in being the…”
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Cloning and characterization of thermo-alkalistable and surfactant stable endoglucanase from Puga hot spring metagenome of Ladakh (J&K) by Gupta, Puneet, Mishra, Arjun K., Vakhlu, Jyoti

“…A thermo-alkalistable and surfactant stable endoglucanase (PHS) gene consisting of 554 amino acids was identified from metagenomic library of Puga hot spring…”
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Crystal structure of basal pilin SpaE reveals the molecular basis of its incorporation in the lactobacillar SpaFED pilus by Megta, Abhin Kumar, Mishra, Arjun K., Palva, Airi, von Ossowski, Ingemar, Krishnan, Vengadesan

“…[Display omitted] •L. rhamnosus GG SpaE basal pilin is structurally determined at 1.5 Å resolution.•SpaE is the first basal pilin structure solved from a…”
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Correction: Cutting Edge: LAG3 Dimerization Is Required for TCR/CD3 Interaction and Inhibition of Antitumor Immunity by Adam, Kieran, Lipatova, Zhanna, Abdul Ghafoor Raja, Maria, Mishra, Arjun K, Mariuzza, Roy A, Workman, Creg J, Vignali, Dario A A

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Cutting Edge: LAG3 Dimerization Is Required for TCR/CD3 Interaction and Inhibition of Antitumor Immunity by Adam, Kieran, Lipatova, Zhanna, Abdul Ghafoor Raja, Maria, Mishra, Arjun K, Mariuzza, Roy A, Workman, Creg J, Vignali, Dario A A

“…Lymphocyte activation gene 3 (LAG3) is an inhibitory receptor that plays a critical role in controlling T cell tolerance and autoimmunity and is a major…”
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CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker by Mishra, Arjun K., Shahid, Salman, Karade, Sharanbasappa S., Agnihotri, Pragati, Kolesnikov, Alexander, Hasan, S. Saif, Mariuzza, Roy A.

“…Lymphocyte activation gene 3 protein (LAG3) is an inhibitory receptor that is upregulated on exhausted T cells in tumors. LAG3 is a major target for cancer…”
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Crystal structure and characterization of nucleoside diphosphate kinase from Vibrio cholerae by Agnihotri, Pragati, Shakya, Anil Kumar, Mishra, Arjun K., Pratap, J. Venkatesh

“…Nucleoside diphosphate kinases (NDK) are ubiquitous enzymes that catalyse the transfer of the γ phosphate from nucleoside triphosphates (NTPs) to nucleoside…”
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Epitope Mapping of Therapeutic Antibodies Targeting Human LAG3 by Agnihotri, Pragati, Mishra, Arjun K., Agarwal, Priyanka, Vignali, Kate M., Workman, Creg J., Vignali, Dario A. A., Mariuzza, Roy A.

“…Lymphocyte activation gene 3 protein (LAG3; CD223) is an inhibitory receptor that is highly upregulated on exhausted T cells in tumors and chronic viral…”
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Identification of Novel Inhibitors of Leishmania donovani γ‑Glutamylcysteine Synthetase Using Structure-Based Virtual Screening, Docking, Molecular Dynamics Simulation, and in Vitro Studies by Agnihotri, Pragati, Mishra, Arjun K, Mishra, Shikha, Sirohi, Vijay Kumar, Sahasrabuddhe, Amogh A, Pratap, J. Venkatesh

“…Trypansomatids maintain their redox balance by the trypanothione-based redox system, enzymes of which exhibit differences from mammalian homologues…”
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Novel protein–protein interaction between spermidine synthase and S-adenosylmethionine decarboxylase from Leishmania donovani by Mishra, Arjun K., Agnihotri, Pragati, Srivastava, Vijay Kumar, Pratap, J. Venkatesh

“…•L. donovani spermidine synthase and S-adenosylmethionine decarboxylase have been cloned and purified.•S-adenosylmethionine decarboxylase has autocatalytic…”
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Crystallization and X‐ray diffraction analysis of SpaE, a basal pilus protein from the gut‐adapted Lactobacillus rhamnosus GG by Mishra, Arjun K., Megta, Abhin Kumar, Palva, Airi, von Ossowski, Ingemar, Krishnan, Vengadesan

“…SpaE is the predicted basal pilin subunit in the sortase‐dependent SpaFED pilus from the gut‐adapted and commensal Lactobacillus rhamnosus GG. Thus far,…”
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Discovery of novel inhibitors for Leishmania nucleoside diphosphatase kinase (NDK) based on its structural and functional characterization by Mishra, Arjun K., Singh, Nidhi, Agnihotri, Pragati, Mishra, Shikha, Singh, Saurabh P., Kolli, Bala K., Chang, Kwang Poo, Sahasrabuddhe, Amogh A., Siddiqi, M. I., Pratap, J. Venkatesh

“…Nucleoside diphosphate kinases (NDKs) are ubiquitous enzymes that catalyze the transfer of the γ-phosphate moiety from an NTP donor to an NDP acceptor, crucial…”
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Epitope Mapping of Therapeutic Antibodies Targeting Human Inhibitory Receptor Lymphocyte Activation Gene 3 Protein (LAG3) by Agnihotri, Pragati, Mishra, Arjun K., Agarwal, Priyanka, Vignali, Kate M., Workman, Creg J., Vignali, Dario A.A., Mariuzza, Roy A.

“…LAG3 (CD223) is an inhibitory receptor that is highly upregulated on exhausted T cells in tumors and chronic viral infection. Consequently, LAG3 is now a major…”
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