UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case

UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case

Drug delivery systems based on calcium phosphate (CaP) coatings have been recently recognized as beneficial drug delivery systems in complex cases of bone diseases for admission of drugs in the localized area, simultaneously inducing osteoinduction because of the bioavailable Ca and P ions. However,...

Full description

Saved in:
Bibliographic Details
Published in:Materials Vol. 15; no. 13; p. 4643
Main Authors: Prosolov, Konstantin A., Komarova, Ekaterina G., Kazantseva, Ekaterina A., Lozhkomoev, Aleksandr S., Kazantsev, Sergei O., Bakina, Olga V., Mishina, Marina V., Zima, Anastasia P., Krivoshchekov, Sergei V., Khlusov, Igor A., Sharkeev, Yurii P.
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-07-2022
MDPI
Subjects:
5-fluorouracil
Antibiotics
Antiinfectives and antibacterials
Arc deposition
Bioavailability
Biodegradation
Biomedical materials
calcium phosphate coating
Calcium phosphates
Cancer therapies
Cavitation
Coatings
drug delivery
Drug delivery systems
Drugs
Electrolytes
Infections
Interferon
interferon α-2b
Oxidation
Phosphate coatings
Porosity
Toxicity
Transplants & implants
Tumors
Ultrasonic testing
ultrasound-assisted micro-arc oxidation (UMAO)
Vancomycin
United States > US
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Drug delivery systems based on calcium phosphate (CaP) coatings have been recently recognized as beneficial drug delivery systems in complex cases of bone diseases for admission of drugs in the localized area, simultaneously inducing osteoinduction because of the bioavailable Ca and P ions. However, micro-arc oxidation (MAO) deposition of CaP does not allow for the formation of a coating with sufficient interconnected porosity for drug delivery purposes. Here, we report on the method to deposit CaP-based coatings using a new hybrid ultrasound-assisted MAO (UMAOH) method for deposition of coatings for drug delivery that could carry various types of drugs, such as cytostatic, antibacterial, or immunomodulatory compositions. Application of UMAOH resulted in coatings with an Ra roughness equal to 3.5 µm, a thickness of 50–55 µm, and a combination of high values of internal and surface porosity, 39 and 28%, respectively. The coating is represented by the monetite phase that is distributed in the matrix of amorphous CaP. Optimal conditions of coating deposition have been determined and used for drug delivery by impregnation with Vancomycin, 5-Fluorouracil, and Interferon-α-2b. Cytotoxicity and antimicrobial activity of the manufactured drug-carrying coatings have been studied using the three different cell lines and methicillin-resistant S. aureus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1996-1944
1996-1944
DOI:10.3390/ma15134643