Search Results - "Mishima, Yuichi"

Interactions of HP1 Bound to H3K9me3 Dinucleosome by Molecular Simulations and Biochemical Assays by Watanabe, Shuhei, Mishima, Yuichi, Shimizu, Masahiro, Suetake, Isao, Takada, Shoji

“…Heterochromatin protein 1 (HP1), associated with heterochromatin formation, recognizes an epigenetically repressive marker, trimethylated lysine 9 in histone…”
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Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells by Otani, Junji, Kimura, Hironobu, Sharif, Jafar, Endo, Takaho A, Mishima, Yuichi, Kawakami, Toru, Koseki, Haruhiko, Shirakawa, Masahiro, Suetake, Isao, Tajima, Shoji

“…Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance…”
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Synthesis of ubiquitylated histone H3 using a thiirane linker for chemical ligation by Kawakami, Toru, Mishima, Yuichi, Hojo, Hironobu, Suetake, Isao

“…Post‐translational modifications of histone proteins, which form nucleosome cores, play an important role in gene regulation. Ubiquitin modification is one…”
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Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy by Suetake, Isao, Nakazawa, Shigeaki, Sato, Kazunobu, Mutoh, Risa, Mishima, Yuichi, Kawakami, Toru, Takei, Toshiki, Watanabe, Mikio, Sakai, Norio, Fujiwara, Toshimichi, Takui, Takeji, Miyata, Makoto, Shinohara, Akira, Hojo, Hironobu, Arata, Toshiaki

“…The structural dynamics of the chromo-shadow domain (CSD) and chromodomain (CD) of human HP1 proteins essential for heterochromatin formation were investigated…”
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Chemical synthesis of the ubiquitinated form of histone H3 and its effect on DNA methyltransferase 1 by Kawakami, Toru, Mishima, Yuichi, Takazawa, Masaya, Hojo, Hironobu, Suetake, Isao

“…Posttranslational modifications of histone proteins, which form nucleosome cores, play an important role in gene regulation. Ubiquitination is one such…”
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Synthesis of histone proteins by CPE ligation using a recombinant peptide as the C-terminal building block by Kawakami, Toru, Yoshikawa, Ryo, Fujiyoshi, Yuki, Mishima, Yuichi, Hojo, Hironobu, Tajima, Shoji, Suetake, Isao

“…The post-translational modification of histones plays an important role in gene expression. We report herein on a method for synthesizing such modified…”
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Enhanced processivity of Dnmt1 by monoubiquitinated histone H3 by Mishima, Yuichi, Brueckner, Laura, Takahashi, Saori, Kawakami, Toru, Otani, Junji, Shinohara, Akira, Takeshita, Kohei, Garvilles, Ronald Garingalao, Watanabe, Mikio, Sakai, Norio, Takeshima, Hideyuki, Nachtegael, Charlotte, Nishiyama, Atsuya, Nakanishi, Makoto, Arita, Kyohei, Nakashima, Kinichi, Hojo, Hironobu, Suetake, Isao

“…DNA methylation controls gene expression, and once established, DNA methylation patterns are faithfully copied during DNA replication by the maintenance DNA…”
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Characterization of DNA-binding activity in the N-terminal domain of the DNA methyltransferase Dnmt3a by Suetake, Isao, Mishima, Yuichi, Kimura, Hironobu, Lee, Young-Ho, Goto, Yuji, Takeshima, Hideyuki, Ikegami, Takahisa, Tajima, Shoji

“…The Dnmt3a gene, which encodes de novo-type DNA methyltransferase, encodes two isoforms, full-length Dnmt3a and Dnmt3a2, which lacks the N-terminal 219 amino…”
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NMR characterization of the interaction of the endonuclease domain of MutL with divalent metal ions and ATP by Mizushima, Ryota, Kim, Ju Yaen, Suetake, Isao, Tanaka, Hiroaki, Takai, Tomoyo, Kamiya, Narutoshi, Takano, Yu, Mishima, Yuichi, Tajima, Shoji, Goto, Yuji, Fukui, Kenji, Lee, Young-Ho

“…MutL is a multi-domain protein comprising an N-terminal ATPase domain (NTD) and C-terminal dimerization domain (CTD), connected with flexible linker regions,…”
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Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance by Ishiyama, Satoshi, Nishiyama, Atsuya, Saeki, Yasushi, Moritsugu, Kei, Morimoto, Daichi, Yamaguchi, Luna, Arai, Naoko, Matsumura, Rumie, Kawakami, Toru, Mishima, Yuichi, Hojo, Hironobu, Shimamura, Shintaro, Ishikawa, Fuyuki, Tajima, Shoji, Tanaka, Keiji, Ariyoshi, Mariko, Shirakawa, Masahiro, Ikeguchi, Mitsunori, Kidera, Akinori, Suetake, Isao, Arita, Kyohei, Nakanishi, Makoto

“…The proper location and timing of Dnmt1 activation are essential for DNA methylation maintenance. We demonstrate here that Dnmt1 utilizes…”
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Nucleosome compaction facilitates HP1γ binding to methylated H3K9 by Mishima, Yuichi, Jayasinghe, Chanika D, Lu, Kai, Otani, Junji, Shirakawa, Masahiro, Kawakami, Toru, Kimura, Hironobu, Hojo, Hironobu, Carlton, Peter, Tajima, Shoji, Suetake, Isao

“…The α, β and γ isoforms of mammalian heterochromatin protein 1 (HP1) selectively bind to methylated lysine 9 of histone H3 via their chromodomains. Although…”
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A thiirane linker for isopeptide mimetics by peptide ligation by Kawakami, Toru, Mishima, Yuichi, Kinoshita, Misaki, Lee, Young-Ho, Suetake, Isao

“…[Display omitted] •A method for introduction of an isopeptide-mimetic structure is proposed.•2-Aminomethylthiirane can be used as a linker for peptide…”
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Dynamics of the HP1 Hinge Region with DNA Measured by Site-Directed Spin Labeling-EPR Spectroscopy by Suetake, Isao, Sato, Kazunobu, Sugishita, Tomoaki, Mishima, Yuichi, Takei, Toshiki, Fujiwara, Toshimichi, Mutoh, Risa, Shinohara, Akira, Takui, Takeji, Miyata, Makoto, Hojo, Hironobu, Arata, Toshiaki

“…An epigenetic reader, heterochromatin protein 1 (HP1), possesses two conserved domains, the chromoshadow domain (CSD) and chromodomain (CD). The CD and CSD are…”
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Hinge and Chromoshadow of HP1α Participate in Recognition of K9 Methylated Histone H3 in Nucleosomes by Mishima, Yuichi, Watanabe, Makoto, Kawakami, Toru, Jayasinghe, Chanika D., Otani, Junji, Kikugawa, Yusuke, Shirakawa, Masahiro, Kimura, Hiroshi, Nishimura, Osamu, Aimoto, Saburo, Tajima, Shoji, Suetake, Isao

“…The majority of the genome in eukaryotes is packaged into transcriptionally inactive chromatin. Heterochromatin protein 1 (HP1) is a major player in the…”
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RFTS‐dependent negative regulation of Dnmt1 by nucleosome structure and histone tails by Mishima, Yuichi, Brueckner, Laura, Takahashi, Saori, Kawakami, Toru, Arita, Kyohei, Oka, Shota, Otani, Junji, Hojo, Hironobu, Shirakawa, Masahiro, Shinohara, Akira, Watanabe, Mikio, Suetake, Isao

“…DNA methylation in promoter regions represses gene expression and is copied over mitotic divisions by Dnmt1. Dnmt1 activity is regulated by its replication…”
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InGaAs tri-gate MOSFETs with MOVPE regrown source/drain by Mishima, Yuichi, Kanazawa, Toru, Kinoshita, Haruki, Uehara, Eiji, Miyamoto, Yasuyuki

“…InGaAs MOSFETs are attractive candidate for future high-speed and low-power-consumption devices. To enhance the performance of that, we propose a novel device…”
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Hinge and Chromoshadow of HP1[alpha] Participate in Recognition of K9 Methylated Histone H3 in Nucleosomes by Mishima, Yuichi, Watanabe, Makoto, Kawakami, Toru, Jayasinghe, Chanika D, Otani, Junji, Kikugawa, Yusuke, Shirakawa, Masahiro, Kimura, Hiroshi, Nishimura, Osamu, Aimoto, Saburo, Tajima, Shoji, Suetake, Isao

“…The majority of the genome in eukaryotes is packaged into transcriptionally inactive chromatin. Heterochromatin protein 1 (HP1) is a major player in the…”
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NMR Characterization of the Interaction of the Endonuclease Domain of MutL with Divalent Metal Ions and ATP: e98554 by Mizushima, Ryota, Kim, Ju Yaen, Suetake, Isao, Tanaka, Hiroaki, Takai, Tomoyo, Kamiya, Narutoshi, Takano, Yu, Mishima, Yuichi, Tajima, Shoji, Goto, Yuji

“…MutL is a multi-domain protein comprising an N-terminal ATPase domain (NTD) and C-terminal dimerization domain (CTD), connected with flexible linker regions,…”
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Cell Cycle-Dependent Turnover of 5-Hydroxymethyl Cytosine in Mouse Embryonic Stem Cells: e82961 by Otani, Junji, Kimura, Hironobu, Sharif, Jafar, Endo, Takaho A, Mishima, Yuichi, Kawakami, Toru, Koseki, Haruhiko, Shirakawa, Masahiro, Suetake, Isao, Tajima, Shoji

“…Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance…”
Get full text