Search Results - "Misharin, A. Yu"

Oxazoline derivatives of [17(20)E]-21-norpregnene – inhibitors of CYP17A1 activity and proliferation of prostate carcinoma cells by Kostin, V. A., Latysheva, A. S., Zolottsev, V. A., Tkachev, Ya. V., Timofeev, V. P., Kuzikov, A. V., Shumyantseva, V. V., Morozevich, G. E., Misharin, A. Yu

“…Nine new oxazolinyl derivatives of [17(20) E ]-21-norpregnene, differing in the structure of steroid moiety, were investigated for their potency to inhibit the…”
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Synthesis of nitrogen-containing derivatives of 17(20)-pregnenoic, 17β-hydroxypregnanoic, and 17α-hydroxypregnanoic acids as new potential antiandrogens by Zolottsev, V. A., Kostin, V. A., Novikov, R. A., Tkachev, Ya. V., Zavialova, M. G., Taratynova, M. O., Latysheva, A. S., Zazulina, O. V., Timofeev, V. P., Misharin, A. Yu

“…A general scheme for the synthesis of oxazoline and benzoxazole derivatives of [17(20) E ]-21-norpregnene differing in the structure of the steroid moiety as…”
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Interaction of novel oxazoline derivatives of 17(20)E-pregna-5,17(20)-diene with cytochrome P450 17A1 by Stulov, S. V., Dugin, N. O., Zharkova, M. S., Shcherbinin, D. S., Kuzikov, A. V., Shumantseva, V. V., Misharin, A. Yu, Veselovsky, A. V.

“…In order to find novel inhibitors of 17α-hydroxylase-17,20-lyase (cytochrome P450 17A1, CYP17A1), a key enzyme of biosynthesis of androgens, molecular docking…”
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Screening of potential substrates or inhibitors of cytochrome P450 17A1 (CYP17A1) by electrochemical methods by Shumyantseva, V. V., Bulko, T. V., Misharin, A. Yu, Archakov, A. I.

“…The electrochemical redox reactions of the recombinant form of human cytochrome P450 17A1 (CYP17A1) were investigated. The hemoprotein was immobilized on the…”
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Biological activity of phytosterols and their derivatives by Mehtiev, A. R., Misharin, A. Yu

“…This review is devoted to contemporary status of investigation of C-29 and C-28 plant sterols (phytosterols) in relation to their biological activity in…”
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Simulation of EPR spectra of the radical TEMPO in water-lipid systems in different microwave ranges by Timofeev, V. P., Misharin, A. Yu, Tkachev, Ya. V.

“…A novel interpretation of EPR spectra of the TEMPO radical in water-lipid media in terms of the model of two independent movements of nitroxyl is presented. A…”
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Synthesis of steroids with nitrogen-containing substituents in ring D (Review) by Stulov, S. V., Misharin, A. Yu

“…Data published over the last 15 years on the chemical synthesis of biologically active steroids with nitrogen-containing substituents (mostly containing…”
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Interaction of novel oxazoline derivatives of 17(20)e-pregna-5,17(20)-diene with cytochrome P450 17A1 by Stulov, S V, Dugin, N O, Zharkova, M S, Shcherbinin, D S, Kuzikov, A V, Shumyantseva, V V, Misharin, A Yu, Veselovsky, A V

“…In order to find novel inhibitors of 17a-hydroxylase-17,20-lyase (cytochrome P450 17A1, CYP17A1), a key enzyme of biosynthesis of androgens, molecular docking…”
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Molecular modeling of the interaction of 17(20)Z- and 17(20)E-pregna-5,17(20)-dien-21-oyl amides with the nuclear receptor LXRβ by Fedyushkina, I. V., Stulov, S. V., Dugin, N. O., Misharin, A. Yu, Mehtiev, A. R., Morozevich, G. E., Veselovsky, A. V.

“…Eight isomeric 17(20) Z - and 17(20) E -pregna-5,17(20)-dien-21-oyl amides, conformationally rigid oxysterol analogues, differing in the structure of the amide…”
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Molecular modeling of the interaction of 17(20)Z- and 17(20)E-pregna-5,17(20)-dien-21-oyl amides with the nuclear receptor LXR[beta] by Fedyushkina, I V, Stulov, S V, Dugin, N O, Misharin, A Yu, Mehtiev, A R, Morozevich, G E, Veselovsky, A V

“…Eight isomeric 17(20)Z- and 17(20)E-pregna-5,17(20)-dien-21-oyl amides, conformationally rigid oxysterol analogues, differing in the structure of the amide…”
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(22R,23R)-3β-hydroxy-22,23-epoxy-5α-ergost-8(14)-en-15-one: Improved synthesis and toxicity to MCF-7 cells by Mehtiev, A. R., Timofeev, V. P., Misharin, A. Yu

“…The chemical synthesis of (22 R ,23 R )-3β-hydroxy-22,23-epoxy-5α-ergost-8(14)-en-15-one from (22 A )-3β-acetoxy-5α-ergosta-7,14,22-triene was improved. The…”
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(22R,23R)-3b-hydroxy-22,23-epoxy-5a-ergost-8(14)-en-15-one: Improved synthesis and toxicity to MCF-7 cells by Mehtiev, A R, Timofeev, V P, Misharin, A Yu

“…The chemical synthesis of (22R,23R)-3b-hydroxy-22,23-epoxy-5a-ergost-8(14)-en-15-one from (22A)-3b-acetoxy-5a-ergosta-7,14,22-triene was improved. The stages…”
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Regulation of cholesterol biosynthesis and metabolism in Hep G2 cells by [Delta]8(14)-15-ketoergostane derivatives by Mehtiev, A R, Fedchenko, V I, Tkachev, Ya V, Timofeev, V P, Misharin, A Yu

“…The comparative study of effects of 5α-cholest-8(14)-en-15-on-3β-ol (I), (22E)-5α-ergosta-8(14),22-dien-15-on-3β-ol (II),…”
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Regulation of cholesterol biosynthesis and metabolism in Hep G2 cells by Δ8(14)-15-ketoergostane derivatives by Mehtiev, A. R., Fedchenko, V. I., Tkachev, Ya. V., Timofeev, V. P., Misharin, A. Yu

“…The comparative study of effects of 5α-cholest-8(14)-en-15-on-3β-ol ( I ), (22E)-5α-ergosta-8(14),22-dien-15-on-3β-ol ( II ),…”
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Synthesis of secasterol and 24-episecasterol and their toxicity for MCF-7 cells by Khripach, V. A, Zhabinskii, V. N, Gulyakevich, O. V, Konstantinova, O. V, Misharin, A. Yu, Mekhtiev, A. R, Timofeev, V. P, Tkachev, Ya. V

“…The convergent synthesis of biosynthetic precursors of brassinosteroids with a Δ₂-bond in cycle A—secasterol and 24-episecasterol—was performed. The key stages…”
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Independent visualization of receptors for the native and modified low density lipoproteins in cell cultures by Krutov, A. A., Misharin, A. Yu, Tsibutsky, V. P., Bushueva, T. L., Babaev, V. R., Repin, V. S.

“…The method is suggested to prepare cholesteryl esters derivatives containing fluorescent chromophores in acyl chains. The reconstitution of low-density…”
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Cytotoxic derivatives of (22R,23R)-dihydroxystigmastane by Drozdov, F. V., Mekhtiev, A. P., Morozevich, G. E., Timofeev, V. P., Misharin, A. Yu

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Cholesterol effect on Apolipoprotein B secretion and binding of low-density lipoproteins hepatoma HepG2 Cells by Fuki, I. V., Preobrazhensky, S. N., Misharin, A. Yu, Bushmakina, N. G., Menshchikov, G. B., Repin, V. S.

“…The effect of cholesterol, oleic acid and recombinant complexes containing apolipoprotein Al/dimyristoylphosphatidylcholine (apoAl/DMPC) on apolipoprotein B…”
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The effects of (22S,23S)- and (22R,23R)-3[beta]-hydroxy-22,23-oxido-5[alpha]-ergost-8(14)-en-15-ones on biosynthesis of cholesteryl esters and activity of acyl-CoA:Cholesterol acyl transferase in Hep G2 cells by Mehtiev, A R, Kozlova, N I, Skripnik, V V, Misharin, A Yu

“…Novel synthetic oxysterols (22S,23S)-3β-hydroxy-22,23-oxido-5α-ergost-8(14)-en-15-one (I) and (22R,23R)-3β-hydroxy-22,23-oxido-5α-ergost-8(14)-en-15-one (II)…”
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The effects of (22S,23S)- and (22R,23R)-3β-hydroxy-22,23-oxido-5α-ergost-8(14)-en-15-ones on biosynthesis of cholesteryl esters and activity of acyl-CoA:Cholesterol acyl transferase in Hep G2 cells by Mehtiev, A. R., Kozlova, N. I., Skripnik, V. V., Misharin, A. Yu

“…Novel synthetic oxysterols (22S,23S)-3β-hydroxy-22,23-oxido-5α-ergost-8(14)-en-15-one ( I ) and (22R,23R)-3β-hydroxy-22,23-oxido-5α-ergost-8(14)-en-15-one ( II…”
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