Search Results - "Misek, D. E."

Identification of novel targets for cancer therapy using expression proteomics by HANASH, S. M, MADOZ-GURPIDE, J, MISEK, D. E

“…Although most drugs target proteins, the proteome has remained largely untapped for the discovery of drug targets. The sequencing of the human genome has had a…”
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Arcuate Nucleus Transcriptome Profiling Identifies Ankyrin Repeat and Suppressor of Cytokine Signalling Box-Containing Protein 4 as a Gene Regulated by Fasting in Central Nervous System Feeding Circuits by Li, J.-Y., Kuick, R., Thompson, R. C., Misek, D. E., Lai, Y.-M., Liu, Y.-Q., Chai, B.-X., Hanash, S. M., Gantz, I.

“…The arcuate nucleus of the hypothalamus is a primary site for sensing blood borne nutrients and hormonal messengers that reflect caloric status. To identify…”
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An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl-phosphatidylinositol mimics some of the metabolic actions of insulin by MISEK, D. E, SALTIEL, A. R

“…Some of the acute actions of insulin may be mediated by an enzyme-modulating inositol phosphate glycan, produced by the insulin-sensitive hydrolysis of…”
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Proteomics-based Identification of RS/DJ-1 as a Novel Circulating Tumor Antigen in Breast Cancer by Le Naour, F, Misek, D E, Krause, M C, Deneux, L, Giordano, T J, Scholl, S, Hanash, S M

“…Purpose: We used a proteomics-based approach to identify tumor proteins that elicit a humoral response in breast carcinoma and that may occur as circulating…”
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Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis by RICKMAN, David S, BOBEK, Miroslav P, MISEK, David E, KUICK, Rork, BLAIVAS, Mila, KURNIT, David M, TAYLOR, Jeremy, HANASH, Samir M

“…Astrocytomas are heterogeneous intracranial glial neoplasms ranging from the highly aggressive malignant glioblastoma multiforme (GBM) to the indolent,…”
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Profiling Changes in Gene Expression during Differentiation and Maturation of Monocyte-derived Dendritic Cells Using Both Oligonucleotide Microarrays and Proteomics by Le Naour, François, Hohenkirk, Lyndon, Grolleau, Annabelle, Misek, David E., Lescure, Pascal, Geiger, James D., Hanash, Samir, Beretta, Laura

“…Dendritic cells (DCs) are antigen-presenting cells that play a major role in initiating primary immune responses. We have utilized two independent approaches,…”
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Analysis of a 43-kDa glycoprotein from the intracellular parasitic nematode Trichinella spiralis by Vassilatis, D.K. (Merck Sharp and Dohme Research Laboratories, Rahway, NJ), Despommier, D, Misek, D.E, Polvere, R.I, Gold, A.M, Ploeg, L.H.T. van der

“…The L1 larvae of the parasitic nematode Trichinella spiralis invade skeletal muscle and initiate a process that has been interpreted to represent skeletal…”
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An Immune Response Manifested by the Common Occurrence of Annexins I and II Autoantibodies and High Circulating Levels of IL-6 in Lung Cancer by Brichory, Franck M., Misek, David E., Yim, Anne-Marie, Krause, Melissa C., Giordano, Thomas J., Beer, David G., Hanash, Samir M.

“…The identification of circulating tumor antigens or their related autoantibodies provides a means for early cancer diagnosis as well as leads for therapy. The…”
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Isoelectric Focusing Nonporous RP HPLC:  A Two-Dimensional Liquid-Phase Separation Method for Mapping of Cellular Proteins with Identification Using MALDI-TOF Mass Spectrometry by Wall, Daniel B, Kachman, Maureen T, Gong, Siyuan, Hinderer, Robert, Parus, Steven, Misek, David E, Hanash, Samir M, Lubman, David M

“…A novel two-dimensional liquid-phase separation method was developed that is capable of resolving large numbers of cellular proteins. The proteins are…”
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Protein based microarrays: A tool for probing the proteome of cancer cells and tissues by Madoz-Gúrpide, Juan, Wang, Hong, Misek, David E., Brichory, Franck, Hanash, Sam M.

“…A novel proteomic approach for probing cell and tissue proteome, which combines liquid phase protein separations with microarray technology has been developed…”
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Microtubules and Actin Filaments Are Not Critically Involved in the Biogenesis of Epithelial Cell Surface Polarity by Pedro J. I. Salas, Misek, David E., Vega-Salas, Dora E., Gundersen, Doris, Cereijido, Marcelino, Rodriguez-Boulan, Enrique

“…We have studied the role of microtubules and actin filaments in the biogenesis of epithelial cell surface polarity, using influenza hemagglutinin and vesicular…”
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Organ-Specific Molecular Classification of Primary Lung, Colon, and Ovarian Adenocarcinomas Using Gene Expression Profiles by Giordano, Thomas J., Shedden, Kerby A., Schwartz, Donald R., Kuick, Rork, Taylor, Jeremy M.G., Lee, Nana, Misek, David E., Greenson, Joel K., Kardia, Sharon L.R., Beer, David G., Rennert, Gad, Cho, Kathleen R., Gruber, Stephen B., Fearon, Eric R., Hanash, Samir

“…Molecular classification of tumors based on their gene expression profiles promises to significantly refine diagnosis and management of cancer patients. The…”
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Biogenesis of epithelial cell polarity: intracellular sorting and vectorial exocytosis of an apical plasma membrane glycoprotein by Misek, D E, Bard, E, Rodriguez-Boulan, E

“…To study the biogenetic pathway of influenza hemagglutinin (HA), a model apical glycoprotein, in polarized epithelial MDCK cells, anti-HA antibodies were added…”
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DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes by EHRLICH, Melanie, BUCHANAN, Kent L, TOMMERUP, Niels, MISEK, David E, ROUILLARD, Jean-Marie, KUICK, Rork, HANASH, Samir M, TSIEN, Fern, GUANCHAO JIANG, BAODONG SUN, UICKER, William, WEEMAES, Corry M. R, SMEETS, Dominique, SPERLING, Karl, BELOHRADSKY, Bernd H

“…ICF (immunodeficiency, centromeric region instability and facial anomalies) is a recessive disease caused by mutations in the DNA methyltransferase 3B gene…”
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Identification of β-Tubulin Isoforms as Tumor Antigens in Neuroblastoma by PRASANNAN, Latha, MISEK, David E, HINDERER, Robert, MICHON, Jean, GEIGER, James D, HANASH, Samir M

“…There is currently substantial interest in the identification of human tumor antigens for diagnosis and immunotherapy of cancer. We have implemented a…”
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The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas by RICKMAN, David S, TYAGI, Rachana, KISH, Phillip E, HANASH, Samir M, ZHU, Xiao-Xiang, BOBEK, Miroslav P, SONG, Suzan, BLAIVAS, Mila, MISEK, David E, ISRAEL, Mark A, KURNIT, David M, ROSS, Donald A

“…The human TAX-1 gene encodes a Mr 135,000 glycoprotein that is transiently expressed on the surface of a subset of neurons during development and is involved…”
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Mouse Model of Human Ovarian Endometrioid Adenocarcinoma Based on Somatic Defects in the Wnt/β-Catenin and PI3K/Pten Signaling Pathways by Wu, Rong, Hendrix-Lucas, Neali, Kuick, Rork, Zhai, Yali, Schwartz, Donald R., Akyol, Aytekin, Hanash, Samir, Misek, David E., Katabuchi, Hidetaka, Williams, Bart O., Fearon, Eric R., Cho, Kathleen R.

“…One histologic subtype of ovarian carcinoma, ovarian endometrioid adenocarcinoma (OEA), frequently harbors mutations that constitutively activate…”
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Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer by LOGSDON, Craig D, SIMEONE, Diane M, BINKLEY, Charles, ARUMUGAM, Thiruvengadam, GREENSON, Joel K, GIORDANO, Thomas J, MISEK, David E, HANASH, Samir

“…The molecular basis of pancreatic cancer is not understood. Previous attempts to determine the specific genes expressed in pancreatic cancer have been hampered…”
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Podocyte hypertrophy, adaptation, and decompensation associated with glomerular enlargement and glomerulosclerosis in the aging rat : Prevention by calorie restriction by WIGGINS, Jocelyn E, GOYAL, Meera, SANDEN, Silja K, WHARRAM, Bryan L, SHEDDEN, Kerby A, MISEK, David E, KUICK, Rork D, WIGGINS, Roger C

“…Whether podocyte depletion could cause the glomerulosclerosis of aging in Fischer 344 rats at ages 2, 6, 17, and 24 mo was evaluated. Ad libitum-fed rats…”
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Molecular classification of papillary thyroid carcinoma : distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis by GIORDANO, Thomas J, KUICK, Rork, GAUGER, Paul, DOHERTY, Gerard, THOMPSON, Norman W, HANASH, Samir, KOENIG, Ronald J, NIKIFOROV, Yuri E, THOMAS, Dafydd G, MISEK, David E, VINCO, Michelle, SANDERS, Donita, ZHAOWEN ZHU, CIAMPI, Raffaele, ROH, Michael, SHEDDEN, Kerby

“…Thyroid cancer poses a significant clinical challenge, and our understanding of its pathogenesis is incomplete. To gain insight into the pathogenesis of…”
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