Search Results - "Mirzaie, Sako"

Inhibitors of SARS-CoV‑2 Entry: Current and Future Opportunities by Xiu, Siyu, Dick, Alexej, Ju, Han, Mirzaie, Sako, Abdi, Fatemeh, Cocklin, Simon, Zhan, Peng, Liu, Xinyong

“…Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2…”
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In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands by Stefanucci, Azzurra, Iobbi, Valeria, Della Valle, Alice, Scioli, Giuseppe, Pieretti, Stefano, Minosi, Paola, Mirzaie, Sako, Novellino, Ettore, Mollica, Adriano

“…The kappa opioid receptor (KOR) represents an attractive target for the development of drugs as potential antidepressants, anxiolytics and analgesics. A robust…”
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Novel potential inhibitor discovery against tyrosyl-tRNA synthetase from Staphylococcus aureus by virtual screening, molecular dynamics, MMPBSA and QMMM simulations by Farshadfar, Chiako, Mollica, Adriano, Rafii, Fatemeh, Noorbakhsh, Akbar, Nikzad, Mozhgan, Seyedi, Seyed Hamid, Abdi, Fatemeh, Verki, Somayeh Abbasi, Mirzaie, Sako

“…The abuse and overuse of antibiotics is the main responsible for the raising antibiotic resistance among bacteria and as a consequence the of diseases severity…”
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Generation of Fam83h knockout mice by CRISPR/Cas9‐mediated gene engineering by Nasseri, Sherko, Nikkho, Bahram, Parsa, Sara, Ebadifar, Asghar, Soleimani, Farzad, Rahimi, Karim, Vahabzadeh, Zakaria, Khadem‐Erfan, Mohammad Bagher, Rostamzadeh, Jalal, Baban, Babak, Banafshi, Omid, Assadollahi, Vahideh, Mirzaie, Sako, Fathi, Fardin

“…Family with sequence similarity 83 member H (FAM83H) protein‐coding geneplay an essential role in the structural organization, calcification of developing…”
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“Smart” Matrix Microneedle Patch Made of Self‐Crosslinkable and Multifunctional Polymers for Delivering Insulin On‐Demand by Liu, Jackie Fule, GhavamiNejad, Amin, Lu, Brian, Mirzaie, Sako, Samarikhalaj, Melisa, Giacca, Adria, Wu, Xiao Yu

“…Abstract A transdermal patch that delivers insulin at high glucose concentrations can offer tremendous advantages to ease the concern of safety and improve the…”
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Discovery of Serine/Threonine-Protein Kinase 4 Inhibitor by Molecular Docking and Molecular Dynamics Studies for Treatment of Diabetes by Abdi, Fatemeh, Movahedi, Monireh, Alavi Nikje, Mir Mohammad, Mirzaie, Sako

“…Background and Aim: Nowadays, diabetes mellitus is a major challenge for human health. Serine/threonine-protein kinase 4 (STK4) is a main regulator of…”
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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads: Experimental studies and molecular dynamics analysis by Lugtu-Pe, Jamie Anne, Zhang, Xuning, Mirzaie, Sako, Chang, Hao Han R., AL-Mousawi, Nour, Chen, Kuan, Li, Yongqiang, Kane, Anil, Bar-Shalom, Daniel, Wu, Xiao Yu

“…Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However,…”
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Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools by Macedonio, Giorgia, Stefanucci, Azzurra, Maccallini, Cristina, Mirzaie, Sako, Novellino, Ettore, Mollica, Adriano

“…The endocannabinoid system (ECS) is activated when natural arachidonic acid derivatives (endogenous cannabinoids or endocannabinoids) bind as lipophilic…”
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Glycyrrhetinic Acid Inhibits Cell Growth and Induces Apoptosis in Ovarian Cancer A2780 Cells by Haghshenas, Venus, Fakhari, Shohreh, Mirzaie, Sako, Rahmani, Mohammadreza, Farhadifar, Fariba, Pirzadeh, Sara, Jalili, Ali

“…Purpose: Accumulating evidence indicates that glycyrrhizin (GZ) and its hydrolyzed metabolite 18-β glycyrrhetinic acid (GA) exhibit anti-inflammatory and…”
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Nicotine inhibition of lycopene cyclase enhances accumulation of carotenoid intermediates by Dunaliella salina CCAP 19/18 by Fazeli, Mohammad Reza, Tofighi, Hossein, Madadkar-Sobhani, Armin, Shahverdi, Ahmad Reza, Nejad-Sattari, Taher, Mirzaie, Sako, Jamalifar, Hossein

“…The effect of nicotine on the regulation of carotenoid production by Dunaliella salina was investigated. Accumulation by the microalga of lycopene, all-trans…”
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Combined virtual screening, MMPBSA, molecular docking and dynamics studies against deadly anthrax: An in silico effort to inhibit Bacillus anthracis nucleoside hydrolase by Karami, Masoumeh, Jalali, Chiya, Mirzaie, Sako

“…Anthrax is a deadly disease caused by Bacillus anthracis, a dangerous biological warfare agent employed for both military and terrorist purposes. A critical…”
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“Smart” Composite Microneedle Patch Stabilizes Glucagon and Prevents Nocturnal Hypoglycemia: Experimental Studies and Molecular Dynamics Simulation by Lu, Brian, GhavamiNejad, Amin, Liu, Jackie Fule, Li, Jason, Mirzaie, Sako, Giacca, Adria, Wu, Xiao Yu

“…Hypoglycemia is a major complication associated with insulin therapy in people with diabetes that could cause life-threatening conditions if untreated…”
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Structure-based virtual screening efforts against HIV-1 reverse transcriptase to introduce the new potent non-nucleoside reverse transcriptase inhibitor by Hosseini, Yaser, Mollica, Adriano, Mirzaie, Sako

“…The human immunodeficiency virus (HIV) which is strictly related to the development of AIDS, is treated by a cocktail of drugs, but due its high propensity…”
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MT2-MMP is differentially expressed in multiple myeloma cells and mediates their growth and progression by Fakhari, Shohreh, Jalili, Ali, Nikkhoo, Bahram, Ghaderi, Bayazid, Boshagh, Mohammad Amin, Mirzaie, Sako, Moradzad, Mohammad

“…Membrane type-matrix metalloproteinases (MT-MMPs) are known as key regulators of cancer progression/metastasis. However, their roles in the growth and…”
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Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies by Ardalan, Noeman, Mirzaie, Sako, Sepahi, Abbas Akhavan, Khavari-Nejad, Ramazan Ali

“…L-Asparaginases (ASNase) belong to a family of amidohydrolases, have both asparaginase and glutaminase activity. Acute lymphocytic leukemia (ALL) is an…”
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Identification and Characterization of Indolebutyroyl Aspartic Acid: A Promising Inhibitor of VIM-2 Metallo-ß-Lactamase Against Carbapenem-Resistant Pseudomonas aeruginosa Strains by Moosavi, Seyedeh Sara, Madani, Mahboobeh, Mirzaie, Sako, Jazani, Nima Hosseini

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Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1 by Bakhtiari, Nuredin, Mirzaie, Sako, Hemmati, Roohullah, Moslemee-jalalvand, Elham, Noori, Ali Reza, Kazemi, Jahanfard

“…Ursolic Acid (UA), a pentacyclic triterpenoid compound, plays a vital role in aging process. However, the role of UA in the regulation of aging and longevity…”
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Selective reduction in glutaminase activity of l‑Asparaginase by asparagine 248 to serine mutation: A combined computational and experimental effort in blood cancer treatment by Aghaeepoor, Mojtaba, Akbarzadeh, Ali, Mirzaie, Sako, Hadian, Asieh, Jamshidi Aval, Sanaz, Dehnavi, Ehsan

“…Type II l‑asparaginase (l‑ASNase) is an FDA approved enzyme drug with extensive applications for treatment of certain blood cancers. However, the therapeutic…”
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Designing new generation of potent inhibitors against membrane-type matrix metalloproteinase-2: a computational effort against multiple myeloma by Fakhari, Shohreh, Stefanucci, Azzurra, Mollica, Adriano, Nikkhoo, Bahram, Tafsiri, Elham, Jalili, Ali, Mirzaie, Sako

“…Matrix metalloproteinases (MMPs) play important roles in cancer progression and, despite their inhibitors have failed in the clinical trials, they have always…”
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Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention by GhavamiNejad, Amin, Lu, Brian, Samarikhalaj, Melisa, Liu, Jackie Fule, Mirzaie, Sako, Pereira, Sandra, Zhou, Liwei, Giacca, Adria, Wu, Xiao Yu

“…Hypoglycemia is a serious and potentially fatal complication experienced by people with insulin-dependent diabetes. The complication is usually caused by…”
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