Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration

Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/k...

Full description

Saved in:

Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 132; no. 4; pp. 959 - 962
Main Authors:	Ostrovskaya, R U, Mirsoev, T K, Romanova, G A, Gudasheva, T A, Kravchenko, E V, Trofimov, C C, Voronina, T A, Seredenin, S B
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-10-2001
Subjects:	Administration, Oral Animals Avoidance Learning Dipeptides - administration & dosage Dipeptides - pharmacology Dose-Response Relationship, Drug Learning - drug effects Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Nootropic Agents - administration & dosage Nootropic Agents - pharmacology Proline - chemistry Rats
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/kg. Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed after initial training. In this respect, GVS-111 principally differs from its main metabolite cycloprolylglycine and standard nootropic piracetam.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1013663126973