Search Results - "Mironov, S L"

Bound Ca2+ moves faster and farther from single open channels than free Ca2 by Mironov, S. L.

“…A concept of Ca 2+ nanodomains established in the cytoplasm after opening single-calcium channels helps mechanistically understand the physiological mechanisms…”
Get full text

Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice by Mironov, S. L.

“…Respiration in vertebrates is generated by a compact network which is located in the lower brainstem but cellular mechanisms which underlie persistent…”
Get full text

Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering by Mironov, S. L., Skorova, E., Hartelt, N., Mironova, L. A., Hasan, M. T., Kügler, S.

“…Rett syndrome caused by MeCP2 mutations is a devastating neurodevelopmental disorder accompanied by severe breathing irregularities. Using transduction of…”
Get full text

Imaging cytoplasmic cAMP in mouse brainstem neurons by Mironov, S L, Skorova, E, Taschenberger, G, Hartelt, N, Nikolaev, V O, Lohse, M J, Kügler, S

“…cAMP is an ubiquitous second messenger mediating various neuronal functions, often as a consequence of increased intracellular Ca2+ levels. While imaging of…”
Get full text

Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBötzinger complex) by Mironov, S. L.

“…Key points •  Rhythmic network activity can be controlled by intracellular signalling pathways but their possible role is largely not yet elucidated. •  This…”
Get full text

Oscillations and hypoxic changes of mitochondrial variables in neurons of the brainstem respiratory centre of mice by Mironov, S. L., Richter, D. W.

“…We studied the functions of mitochondria and their hypoxic modulation in the brainstem slices of neonatal mice (postnatal day (P)6-11). The measurements were…”
Get full text

Spontaneous and evoked neuronal activities regulate movements of single neuronal mitochondria by Mironov, S.L.

“…Mitochondria produce ATP and act as internal Ca2+ storage sites in neurons. Their localization at active synapses can be beneficial both for the maintenance of…”
Get full text

Single KATP channel opening in response to stimulation of AMPA/kainate receptors is mediated by Na+ accumulation and submembrane ATP and ADP changes by Mollajew, R., Toloe, J., Mironov, S. L.

“…Key points •  KATP channels can suppress overexcitation of CNS neurons after activation of glutamatergic receptors (GluRs), and we examined this functional…”
Get full text

L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia by Mironov, S. L., Richter, D. W.

“…Whole-cell ( I Ca ) and single Ca 2+ channel currents were measured in inspiratory neurones of neonatal mice (4–12 days old). During whole-cell recordings, I…”
Get full text

A1 Adenosine Receptors Modulate Respiratory Activity of the Neonatal Mouse Via the cAMP-Mediated Signaling Pathway by Mironov, S. L, Langohr, K, Richter, D. W

“…S. L. Mironov , K. Langohr , and D. W. Richter II Department of Physiology, University of Göttingen, 37073 Göttingen, Germany Mironov, S. L., K. Langohr, and…”
Get full text

Metabolic differences in hippocampal ‘Rett’ neurons revealed by ATP imaging by Toloe, J., Mollajew, R., Kügler, S., Mironov, S.L.

“…Understanding metabolic control of neuronal function requires detailed knowledge of ATP handling in living neurons. We imaged ATP in organotypic hippocampal…”
Get full text

Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice by Mironov, S. L., Langohr, K., Haller, M., Richter, D. W.

“…The respiratory centre of neonatal mice (4 to 12 days old) was isolated in 700 μm thick brainstem slices. Whole-cell K + currents and single ATP-dependent…”
Get full text

Intrinsic Optical Signals in Respiratory Brain Stem Regions of Mice: Neurotransmitters, Neuromodulators, and Metabolic Stress by Haller, M, Mironov, S. L, Richter, D. W

“…Physiologisches Institut, Georg-August-Universität Göttingen, D-37073 Gottingen, Germany Haller, M., S. L. Mironov, and D. W. Richter. Intrinsic Optical…”
Get full text

Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome by Mironov, S.L., Skorova, E.Y., Kügler, S.

“…Rett Syndrome (RTT) is a neurodevelopmental disease thought to be caused by deficits in synaptogenesis and neuronal circuitry. cAMP is one of the key factors…”
Get full text

Ethanol actions on the mechanisms of Ca2+ mobilization in rat hippocampal cells are mediated by protein kinase C by MIRONOV, S. L, HERMANN, A

“…The effects of ethanol on intracellular free Ca(2+) concentration, [Ca](i), were studied in cultured rat hippocampal neurons using fluo-3 and confocal…”
Get full text

Dynamic activation of KATP channels in rhythmically active neurons by Haller, M., Mironov, S. L., Karschin, A., Richter, D. W.

“…The respiratory centre within the brainstem is one of the most active neuronal networks that generates ongoing rhythmic activity. Stabilization of such vital…”
Get full text

Cytoskeleton mediates inhibition of the fast Na+ current in respiratory brainstem neurons during hypoxia by Mironov, S. L., Richter, D. W.

“…Whole‐cell Na+ currents (INa) were recorded in inspiratory neurons in a medullary slice preparation from neonatal mouse that contains the functional…”
Get full text

Imaging of respiratory network topology in living brainstem slices by Hartelt, N., Skorova, E., Manzke, T., Suhr, M., Mironova, L., Kügler, S., Mironov, S.L.

“…Topology of neuronal networks contributes to their functioning but the structure–function relationships are not yet understood. In order to reveal the spatial…”
Get full text

Bound Ca 2+ moves faster and farther from single open channels than free Ca 2 by Mironov, S L

“…A concept of Ca nanodomains established in the cytoplasm after opening single-calcium channels helps mechanistically understand the physiological mechanisms of…”
Get full text

Cytoplasmic alkalinization increases high-threshold calcium current in chick dorsal root ganglion neurones by MIRONOV, S. L, LUX, H. D

“…Changes of calcium currents with intracellular pH (pHi) were investigated in chick dorsal root ganglion (DRG) neurones. High-threshold calcium currents…”
Get full text