Metabolic and histological parameters of silver catfish ( Rhamdia quelen) exposed to commercial formulation of 2,4-dichlorophenoxiacetic acid (2,4-D) herbicide

The objective of this study was to investigate the effects of commercial formulation of herbicide 2,4-D on metabolic parameters, acetylcholinesterase (AChE) activity and liver histological evaluation of silver catfish ( Rhamdia quelen) exposed for 96 h. AChE activity increased in brain (600 and 700...

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Published in:	Pesticide biochemistry and physiology Vol. 92; no. 3; pp. 133 - 137
Main Authors:	Cattaneo, R., Loro, V.L., Spanevello, R., Silveira, F.A., Luz, L., Miron, D.S., Fonseca, M.B., Moraes, B.S., Clasen, B.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-11-2008 Elsevier
Subjects:	2,4-D AChE Biological and medical sciences blood plasma catfish Chemical control enzyme activity fish Fundamental and applied biological sciences. Psychology glycogen Histology lethal concentration 50 liver Metabolic response metabolism muscles Parasitic plants. Weeds physiological response Phytopathology. Animal pests. Plant and forest protection Rhamdia quelen Silver catfish toxicity testing Weeds AChE Histology 2,4-D Metabolic response Silver catfish Enzyme Pesticides Esterases Systemic Acetylcholinesterase Metabolism Herbicide Carboxylic ester hydrolases Response Silver Group IB metal Vertebrata Formulation Pisces Hydrolases Parameter Phytohormone
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Summary:	The objective of this study was to investigate the effects of commercial formulation of herbicide 2,4-D on metabolic parameters, acetylcholinesterase (AChE) activity and liver histological evaluation of silver catfish ( Rhamdia quelen) exposed for 96 h. AChE activity increased in brain (600 and 700 mg L −1) and decreased in all concentrations tested in muscle tissue. Hepatic glycogen was reduced after 2,4-D exposure ranging from 47.67% (400 mg L −1) until 59.3% (700 mg L −1). Hepatic tissue showed lactate reduction at all 2,4-D concentrations tested and glucose was reduced only at 700 mg L −1. In the highest concentration tested hepatic glycogen and glucose reduced instead plasma glucose levels increased. White muscle tissue showed glycogen reduction in fingerlings exposed to all herbicide concentrations and glucose reduction at 700 mg L −1. Muscle lactate levels increase at all 2,4-D concentrations tested. Vacuolation of hepatocytes and changes in its arrangement cords were observed by histologic analysis in group treated with 700 mg/L of 2,4-D. These results suggest that silver catfish exposed to concentrations of 2,4-D near of CL 50 showed metabolic and histological response to compensate some stress caused by herbicide exposure. Taken together parameters measured can be used as biomarkers to monitor herbicide contaminated water.
Bibliography:	http://dx.doi.org/10.1016/j.pestbp.2008.07.004 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0048-3575 1095-9939
DOI:	10.1016/j.pestbp.2008.07.004