Search Results - "Mirmehrabi, Mahmoud"

Thermodynamic modeling of activity coefficient and prediction of solubility: Part 1. Predictive models by Mirmehrabi, Mahmoud, Rohani, Sohrab, Perry, Luisa

“…A new activity coefficient model was developed from excess Gibbs free energy in the form G(ex) = cA(a) x(1)(b)...x(n)(b). The constants of the proposed model…”
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Supercritical Carbon Dioxide for Pharmaceutical Co-Crystal Production by MacEachern, Lauren, Kermanshahi-pour, Azadeh, Mirmehrabi, Mahmoud

“…Pharmaceuticals in Biopharmaceutics Classification System (BCS) Class II (low solubility, high permeability) are often modified to improve kinetic solubility…”
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Transformation under pressure: Discovery of a novel crystalline form of anthelmintic drug Praziquantel using high-pressure supercritical carbon dioxide by MacEachern, Lauren, Kermanshahi-pour, Azadeh, Mirmehrabi, Mahmoud

“…[Display omitted] •Novel forms of praziquantel found by supercritical CO2 processing.•Novel praziquantel showed 13–20% improved solubility and was stable for…”
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Measurement and Prediction of the Solubility of Stearic Acid Polymorphs by the UNIQUAC Equation by Mirmehrabi, Mahmoud, Rohani, Sohrab

“…The solubility of stearic acid polymorphs B and C in methanol, 2‐butanone, decane and hexane was measured using a precise gravimetric method. Stearic acid is a…”
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Insight into the Formation of Heteromolecular Hydrogen Bonds between Dasatinib and GRAS Molecules by Mondal, Pradip Kumar, Mirmehrabi, Mahmoud, Rohani, Sohrab

“…Purpose: To obtain multicomponent crystals and salts of dasatinib, a weakly basic oral anticancer agent, to improve its solubility and dissolution rate…”
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Co-amorphous solids of dasatinib and olanzapine by saccharin with promising physicochemical properties by Samipillai, Marivel, Mirmehrabi, Mahmoud, Rohani, Sohrab

“…Two co-amorphous compounds of poorly water-soluble drugs dasatinib (DAS) and olanzapine (OLA) were formed, dasatinib-saccharin (DAS-SAC), and…”
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Virtual Multicomponent Crystal Screening: Hydrogen Bonding Revisited by Ahmadi, Soroush, Mondal, Pradip Kumar, Wu, Yuanyi, Gong, Weizhong, Mirmehrabi, Mahmoud, Rohani, Sohrab

“…Pharmaceutical cocrystals, salts, and multicomponent crystals, in general, have increasingly come under the spotlight in recent years. A fast and efficient a…”
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Influence of solvent selection and RESS processing conditions on formation of a praziquantel-malonic acid cocrystal in supercritical CO2 by MacEachern, Lauren A., O’Connor, Grace, Shojaeiarani, Jamileh, Mirmehrabi, Mahmoud, Kermanshahi-pour, Azadeh

“…Praziquantel (PZQ) is an anthelmintic drug with low solubility, therefore cocrystallization and particle size reduction is desirable to improve…”
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Improving the filterability and solid density of ranitidine hydrochloride Form 1 by Mirmehrabi, Mahmoud, Rohani, Sohrab, Murthy, K S Keshava, Radatus, Bruno

“…Ranitidine hydrochloride Form 1 produced by the original method (Price et al., 1978 US patent) has poor filtration and drying characteristics, which make it…”
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Cocrystal formation of niclosamide and urea in supercritical CO2 and impact of cosolvent by MacEachern, L., Kermanshahi-pour, A., Mirmehrabi, Mahmoud, Ajiboye, L., Trivedi, V., Rohani, S., He, Q.

“…A cocrystal of niclosamide and urea was attempted for the first time using a crystallization in supercritical solvent (CSS). Experiments were conducted at…”
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Corrections for "Thermodynamic modeling of activity coefficient and prediction of solubility. Parts 1 and 2," Journal of Pharmaceutical Sciences 95(4) 2006, pp 790-809 by Mirmehrabi, Mahmoud, Rohani, Sohrab

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A novel process for preparation of fatty acid oil mixture in solid form by Kermanshahi pour, Azadeh, MacEachern, Lauren, Mirmehrabi, Mahmoud

“…•A novel process for the precipitation of fatty acids in solid form is developed.•Reaction of oil with a metal base results in formation of powder using…”
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Aminodifluorosulfinium Salts: Selective Fluorination Reagents with Enhanced Thermal Stability and Ease of Handling by L’Heureux, Alexandre, Beaulieu, Francis, Bennett, Christopher, Bill, David R, Clayton, Simon, LaFlamme, François, Mirmehrabi, Mahmoud, Tadayon, Sam, Tovell, David, Couturier, Michel

“…Diethylaminodifluorosulfinium tetrafluoroborate (XtalFluor-E) and morpholinodifluorosulfinium tetrafluoroborate (XtalFluor-M) are crystalline fluorinating…”
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Characterization of new crystalline forms of hydroxyprogesterone caproate by Caplette, Jeffrey, Frigo, Timothy, Jozwiakowski, Michael, Shea, Helene, Mirmehrabi, Mahmoud, Müller, Peter

“…[Display omitted] A systematic polymorph screening process was conducted on the steroid hydroxyprogesterone caproate, which had only one previously described…”
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A novel process for isolation and purification of polyunsaturated fatty acids from a thraustochytrid by Kermanshahi pour, Azadeh, Mirmehrabi, Mahmoud, Brar, Satinder Kaur

“…A novel and scalable process is developed for the extraction and purification of polyunsaturated fatty acids from marine thraustochytrid, consisting of…”
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An approach to solvent screening for crystallization of polymorphic pharmaceuticals and fine chemicals by Mirmehrabi, Mahmoud, Rohani, Sohrab

“…It is desirable to have a systematic approach for predicting or interpreting the effect of the solvents on the production of polymorphs. A method based on the…”
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Polymorphic Generation through Solvent Selection:  Ranitidine Hydrochloride by Trifkovic, Milana, Rohani, Sohrab, Mirmehrabi, Mahmoud

“…The fundamental processes of crystal nucleation and growth are strongly dependent on the solvents used in the crystallization process. Consequently, the…”
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Thermodynamic modeling of activity coefficient and prediction of solubility: Part 2. Semipredictive or semiempirical models by Mirmehrabi, Mahmoud, Rohani, Sohrab, Perry, Luisa

“…The solubility of stearic acid, ranitidine hydrochloride, and stavudine were predicted in selected organic solvents. The experimental solubility data of…”
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Predicting Solubilities of Pharmaceutical Compounds by Rohani, Sohrab, Mirmehrabi, Mahmoud

“…Figures 1 and 2 illustrate the experimental solubility data along with the predicted results. The [Hildebrand] equation resulted in a very large number for the…”
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Polymorphic Behavior and Crystal Habit of an Anti-Viral/HIV Drug:  Stavudine by Mirmehrabi, Mahmoud, Rohani, Sohrab, Murthy, K. S. Keshava, Radatus, Bruno

“…Different characterization methods (optical microscopy, Karl Ficher titration (KF), XRPD, and solid-state FTIR) were used to identify the two polymorphs and…”
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