Search Results - "Miriam Cnop"

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure by Eizirik, Décio L., Pasquali, Lorenzo, Cnop, Miriam

“…Loss of functional β-cell mass is the key mechanism leading to the two main forms of diabetes mellitus — type 1 diabetes mellitus (T1DM) and type 2 diabetes…”
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Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes by Cnop, Miriam

“…The prevalence of Type 2 diabetes is increasing dramatically as a result of the obesity epidemic, and poses a major health and socio-economic burden. Type 2…”
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Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence by Shrestha, Neha, De Franco, Elisa, Arvan, Peter, Cnop, Miriam

“…The notion that in diabetes pancreatic β-cells express endoplasmic reticulum (ER) stress markers indicative of increased unfolded protein response (UPR)…”
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Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells by Cnop, Miriam, Toivonen, Sanna, Igoillo-Esteve, Mariana, Salpea, Paraskevi

“…Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying…”
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The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus by Eizirik, Décio L, Cardozo, Alessandra K, Cnop, Miriam

“…Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis of diabetes, contributing to pancreatic β-cell loss and…”
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Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells by Demine, Stéphane, Schiavo, Andrea Alex, Marín-Cañas, Sandra, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L

“…Adult human pancreatic beta cells are the "gold standard" for studies on diabetes pathogenesis, but their use is limited by insufficient availability and…”
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RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate by CNOP, Miriam, ABDULKARIM, Baroj, BUGLIANI, Marco, LADRIERE, Laurence, MARSELLI, Lorella, MCCARTHY, Mark I, MARCHETTI, Piero, SAMMETH, Michael, EIZIRIK, Décio L, BOTTU, Guy, CUNHA, Daniel A, IGOILLO-ESTEVE, Mariana, MASINI, Matilde, TURATSINZE, Jean-Valery, GRIEBEL, Thasso, VILLATE, Olatz, SANTIN, Izortze

“…Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to…”
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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines by Eizirik, Décio L, Sammeth, Michael, Bouckenooghe, Thomas, Bottu, Guy, Sisino, Giorgia, Igoillo-Esteve, Mariana, Ortis, Fernanda, Santin, Izortze, Colli, Maikel L, Barthson, Jenny, Bouwens, Luc, Hughes, Linda, Gregory, Lorna, Lunter, Gerton, Marselli, Lorella, Marchetti, Piero, McCarthy, Mark I, Cnop, Miriam

“…Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells…”
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Health-related fitness benefits following concurrent high-intensity interval training and resistance training in patients with type-1 diabetes or type-2 diabetes by Scoubeau, Corentin, Klass, Malgorzata, Celie, Bert, Godefroid, Chantal, Cnop, Miriam, Faoro, Vitalie

“…IntroductionCardiorespiratory fitness (CRF), as assessed by VO2peak, along with metabolic and cardiovascular health indices, represents the strongest…”
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YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress by De Franco, Elisa, Lytrivi, Maria, Ibrahim, Hazem, Montaser, Hossam, Wakeling, Matthew N, Fantuzzi, Federica, Patel, Kashyap, Demarez, Céline, Cai, Ying, Igoillo-Esteve, Mariana, Cosentino, Cristina, Lithovius, Väinö, Vihinen, Helena, Jokitalo, Eija, Laver, Thomas W, Johnson, Matthew B, Sawatani, Toshiaki, Shakeri, Hadis, Pachera, Nathalie, Haliloglu, Belma, Ozbek, Mehmet Nuri, Unal, Edip, Yıldırım, Ruken, Godbole, Tushar, Yildiz, Melek, Aydin, Banu, Bilheu, Angeline, Suzuki, Ikuo, Flanagan, Sarah E, Vanderhaeghen, Pierre, Senée, Valérie, Julier, Cécile, Marchetti, Piero, Eizirik, Decio L, Ellard, Sian, Saarimäki-Vire, Jonna, Otonkoski, Timo, Cnop, Miriam, Hattersley, Andrew T

“…Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or impairing β cell function. Understanding the genetic basis of rare…”
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Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity by Oshima, Masaya, Pechberty, Séverine, Bellini, Lara, Göpel, Sven O., Campana, Mélanie, Rouch, Claude, Dairou, Julien, Cosentino, Cristina, Fantuzzi, Federica, Toivonen, Sanna, Marchetti, Piero, Magnan, Christophe, Cnop, Miriam, Le Stunff, Hervé, Scharfmann, Raphaël

“…Aims/hypothesis During the onset of type 2 diabetes, excessive dietary intake of saturated NEFA and fructose lead to impaired insulin production and secretion…”
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Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets by Saponaro, Chiara, Mühlemann, Markus, Acosta-Montalvo, Ana, Piron, Anthony, Gmyr, Valery, Delalleau, Nathalie, Moerman, Ericka, Thévenet, Julien, Pasquetti, Gianni, Coddeville, Anais, Cnop, Miriam, Kerr-Conte, Julie, Staels, Bart, Pattou, François, Bonner, Caroline

“…Studies implicating sodium-glucose cotransporter 2 (SGLT2) inhibitors in glucagon secretion by pancreatic α-cells reported controversial results. We…”
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tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors by Arroyo, Maria Nicol, Green, Jonathan Alex, Cnop, Miriam, Igoillo-Esteve, Mariana

“…The global rise in type 2 diabetes results from a combination of genetic predisposition with environmental assaults that negatively affect insulin action in…”
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Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance by Patel, Kashyap A., Kettunen, Jarno, Laakso, Markku, Stančáková, Alena, Laver, Thomas W., Colclough, Kevin, Johnson, Matthew B., Abramowicz, Marc, Groop, Leif, Miettinen, Päivi J., Shepherd, Maggie H., Flanagan, Sarah E., Ellard, Sian, Inagaki, Nobuya, Hattersley, Andrew T., Tuomi, Tiinamaija, Cnop, Miriam, Weedon, Michael N.

“…Finding new causes of monogenic diabetes helps understand glycaemic regulation in humans. To find novel genetic causes of maturity-onset diabetes of the young…”
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Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes by Marselli, Lorella, Piron, Anthony, Suleiman, Mara, Colli, Maikel L., Yi, Xiaoyan, Khamis, Amna, Carrat, Gaelle R., Rutter, Guy A., Bugliani, Marco, Giusti, Laura, Ronci, Maurizio, Ibberson, Mark, Turatsinze, Jean-Valery, Boggi, Ugo, De Simone, Paolo, De Tata, Vincenzo, Lopes, Miguel, Nasteska, Daniela, De Luca, Carmela, Tesi, Marta, Bosi, Emanuele, Singh, Pratibha, Campani, Daniela, Schulte, Anke M., Solimena, Michele, Hecht, Peter, Rady, Brian, Bakaj, Ivona, Pocai, Alessandro, Norquay, Lisa, Thorens, Bernard, Canouil, Mickaël, Froguel, Philippe, Eizirik, Decio L., Cnop, Miriam, Marchetti, Piero

“…Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress…”
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Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals by Rodriguez, Julie, Neyrinck, Audrey M, Van Kerckhoven, Maxime, Gianfrancesco, Marco A, Renguet, Edith, Bertrand, Luc, Cani, Patrice D, Lanthier, Nicolas, Cnop, Miriam, Paquot, Nicolas, Thissen, Jean-Paul, Bindels, Laure B, Delzenne, Nathalie M

“…Dietary interventions targeting the gut microbiota have been proposed as innovative strategies to improve obesity-associated metabolic disorders. Increasing…”
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The Role of Beta Cell Recovery in Type 2 Diabetes Remission by Suleiman, Mara, Marselli, Lorella, Cnop, Miriam, Eizirik, Decio L, De Luca, Carmela, Femia, Francesca R, Tesi, Marta, Del Guerra, Silvia, Marchetti, Piero

“…Type 2 diabetes (T2D) has been considered a relentlessly worsening disease, due to the progressive deterioration of the pancreatic beta cell functional mass…”
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In vitro use of free fatty acids bound to albumin: A comparison of protocols by Oliveira, Ana F, Cunha, Daniel A, Ladriere, Laurence, Igoillo-Esteve, Mariana, Bugliani, Marco, Marchetti, Piero, Cnop, Miriam

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Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial by Neyrinck, Audrey M., Rodriguez, Julie, Zhang, Zhengxiao, Seethaler, Benjamin, Sánchez, Cándido Robles, Roumain, Martin, Hiel, Sophie, Bindels, Laure B., Cani, Patrice D., Paquot, Nicolas, Cnop, Miriam, Nazare, Julie-Anne, Laville, Martine, Muccioli, Giulio G., Bischoff, Stephan C., Walter, Jens, Thissen, Jean-Paul, Delzenne, Nathalie M.

“…Purpose Inulin-type fructans (ITF) are prebiotic dietary fibre (DF) that may confer beneficial health effects, by interacting with the gut microbiota. We have…”
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A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis by Fjeld, Karianne, Weiss, Frank Ulrich, Lasher, Denise, Rosendahl, Jonas, Chen, Jian-Min, Johansson, Bente B, Kirsten, Holger, Ruffert, Claudia, Masson, Emmanuelle, Steine, Solrun J, Bugert, Peter, Cnop, Miriam, Grützmann, Robert, Mayerle, Julia, Mössner, Joachim, Ringdal, Monika, Schulz, Hans-Ulrich, Sendler, Matthias, Simon, Peter, Sztromwasser, Paweł, Torsvik, Janniche, Scholz, Markus, Tjora, Erling, Férec, Claude, Witt, Heiko, Lerch, Markus M, Njølstad, Pål R, Johansson, Stefan, Molven, Anders

“…Anders Molven and colleagues show that a recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. The…”
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