Search Results - "Mire, Chad"

Post-exposure treatments for Ebola and Marburg virus infections by Cross, Robert W., Mire, Chad E., Feldmann, Heinz, Geisbert, Thomas W.

“…Key Points The filoviruses, Ebola virus and Marburg virus, cause lethal haemorrhagic fever in humans and non-human primates (NHPs), and there are currently no…”
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Current Ebola Virus Vaccine Progress by Marzi, Andrea, Mire, Chad E.

“…Over 40 years since the discovery of Ebola virus, the anti-Ebola virus vaccine efforts of the past 2 decades have culminated in over 12 different vaccine…”
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Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates by Thi, Emily P., Mire, Chad E., Lee, Amy C. H., Geisbert, Joan B., Zhou, Joy Z., Agans, Krystle N., Snead, Nicholas M., Deer, Daniel J., Barnard, Trisha R., Fenton, Karla A., MacLachlan, Ian, Geisbert, Thomas W.

“…Ebola-virus-targeting short interfering RNAs (siRNAs) encapsulated in lipid nanoparticles are adapted to the current outbreak strain of the virus, and the…”
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A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates by Callendret, Benoit, Vellinga, Jort, Wunderlich, Kerstin, Rodriguez, Ariane, Steigerwald, Robin, Dirmeier, Ulrike, Cheminay, Cedric, Volkmann, Ariane, Brasel, Trevor, Carrion, Ricardo, Giavedoni, Luis D, Patterson, Jean L, Mire, Chad E, Geisbert, Thomas W, Hooper, Jay W, Weijtens, Mo, Hartkoorn-Pasma, Jutta, Custers, Jerome, Grazia Pau, Maria, Schuitemaker, Hanneke, Zahn, Roland

“…The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal…”
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Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome by Luthra, Priya, Ramanan, Parameshwaran, Mire, Chad E., Weisend, Carla, Tsuda, Yoshimi, Yen, Benjamin, Liu, Gai, Leung, Daisy W., Geisbert, Thomas W., Ebihara, Hideki, Amarasinghe, Gaya K., Basler, Christopher F.

“…The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces type I IFN responses to control viral replication. The cellular dsRNA…”
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Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever by Mire, Chad E, Cross, Robert W, Geisbert, Joan B, Borisevich, Viktoriya, Agans, Krystle N, Deer, Daniel J, Heinrich, Megan L, Rowland, Megan M, Goba, Augustine, Momoh, Mambu, Boisen, Mathew L, Grant, Donald S, Fullah, Mohamed, Khan, Sheik Humarr, Fenton, Karla A, Robinson, James E, Branco, Luis M, Garry, Robert F, Geisbert, Thomas W

“…Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including…”
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The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses by Pécheur, Eve-Isabelle, Borisevich, Viktoriya, Halfmann, Peter, Morrey, John D, Smee, Donald F, Prichard, Mark, Mire, Chad E, Kawaoka, Yoshihiro, Geisbert, Thomas W, Polyak, Stephen J

“…Arbidol (ARB) is a synthetic antiviral originally developed to combat influenza viruses. ARB is currently used clinically in several countries but not in North…”
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Vesicular stomatitis virus-based vaccines protect nonhuman primates against Bundibugyo ebolavirus by Mire, Chad E, Geisbert, Joan B, Marzi, Andrea, Agans, Krystle N, Feldmann, Heinz, Geisbert, Thomas W

“…Ebola virus (EBOV) causes severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Currently, there are no licensed vaccines or…”
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Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever by Rodriguez, Sergio E., Cross, Robert W., Fenton, Karla A., Bente, Dennis A., Mire, Chad E., Geisbert, Thomas W.

“…Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host…”
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Comparison of Zaire and Bundibugyo Ebolavirus Polymerase Complexes and Susceptibility to Antivirals through a Newly Developed Bundibugyo Minigenome System by Levine, Corri B, Mire, Chad E, Geisbert, Thomas W

“…Members of the genus cause lethal disease in humans, with (EBOV) being the most pathogenic (up to 90% morality) and ebolavirus (BDBV) the least pathogenic…”
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A recombinant vesicular stomatitis virus-based Lassa fever vaccine protects guinea pigs and macaques against challenge with geographically and genetically distinct Lassa viruses by Safronetz, David, Mire, Chad, Rosenke, Kyle, Feldmann, Friederike, Haddock, Elaine, Geisbert, Thomas, Feldmann, Heinz

“…Lassa virus (LASV) is endemic in several West African countries and is the etiological agent of Lassa fever. Despite the high annual incidence and significant…”
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The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for 3 Species of Ebolavirus by Cross, Robert W., Mire, Chad E., Borisevich, Viktoriya, Geisbert, Joan B., Fenton, Karla A., Geisbert, Thomas W.

“…Small-animal models have been developed for several Filoviridae species; however, serial adaptation was required to produce lethal infection. These adapted…”
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The immunomodulating V and W proteins of Nipah virus determine disease course by Satterfield, Benjamin A., Cross, Robert W., Fenton, Karla A., Agans, Krystle N., Basler, Christopher F., Geisbert, Thomas W., Mire, Chad E.

“…The viral determinants that contribute to Nipah virus (NiV)-mediated disease are poorly understood compared with other paramyxoviruses. Here we use recombinant…”
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Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates by Mire, Chad E, Geisbert, Joan B, Agans, Krystle N, Satterfield, Benjamin A, Versteeg, Krista M, Fritz, Elizabeth A, Feldmann, Heinz, Hensley, Lisa E, Geisbert, Thomas W

“…The filoviruses, Marburg virus (MARV) and Ebola virus, causes severe hemorrhagic fever with high mortality in humans and nonhuman primates. A promising…”
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Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease by Mire, Chad E, Geisbert, Joan B, Agans, Krystle N, Versteeg, Krista M, Deer, Daniel J, Satterfield, Benjamin A, Fenton, Karla A, Geisbert, Thomas W

“…Nipah virus (NiV) is a zoonotic pathogen that causes high case-fatality rates (CFRs) in humans. Two NiV strains have caused outbreaks: the Malaysia strain (NiV…”
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An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections by Dang, Ha V., Chan, Yee-Peng, Park, Young-Jun, Snijder, Joost, Da Silva, Sofia Cheliout, Vu, Bang, Yan, Lianying, Feng, Yan-Ru, Rockx, Barry, Geisbert, Thomas W., Mire, Chad E., Broder, Christopher C., Veesler, David

“…Nipah virus (NiV) and Hendra virus (HeV) are zoonotic henipaviruses (HNVs) responsible for outbreaks of encephalitis and respiratory illness with fatality…”
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The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus by Jasenosky, Luke D., Cadena, Cristhian, Mire, Chad E., Borisevich, Viktoriya, Haridas, Viraga, Ranjbar, Shahin, Nambu, Aya, Bavari, Sina, Soloveva, Veronica, Sadukhan, Supriya, Cassell, Gail H., Geisbert, Thomas W., Hur, Sun, Goldfeld, Anne E.

“…Here, we show that the US Food and Drug Administration-approved oral drug nitazoxanide (NTZ) broadly amplifies the host innate immune response to viruses and…”
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Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy by Mire, Chad E., Satterfield, Benjamin A., Geisbert, Joan B., Agans, Krystle N., Borisevich, Viktoriya, Yan, Lianying, Chan, Yee-Peng, Cross, Robert W., Fenton, Karla A., Broder, Christopher C., Geisbert, Thomas W.

“…Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M ) and Bangladesh…”
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The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway by Edwards, Megan R, Johnson, Britney, Mire, Chad E, Xu, Wei, Shabman, Reed S, Speller, Lauren N, Leung, Daisy W, Geisbert, Thomas W, Amarasinghe, Gaya K, Basler, Christopher F

“…Kelch-like ECH-associated protein 1 (Keap1) is a ubiquitin E3 ligase specificity factor that targets transcription factor nuclear factor (erythroid-derived…”
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The Mucin-Like Domain of the Ebola Glycoprotein Does Not Impact Virulence or Pathogenicity in Ferrets by Halfmann, Peter J, Borisevich, Viktoriya, Levine, Corri B, Mire, Chad E, Fenton, Karla A, Geisbert, Thomas W, Kawaoka, Yoshihiro, Cross, Robert W

“…Abstract Background Ebola virus (EBOV) is considered among the most dangerous viruses with case fatality rates approaching 90% depending on the outbreak. While…”
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