Search Results - "Miratul M. K. Muqit"

PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease by Kazlauskaite, Agne, Muqit, Miratul M. K

“…The discovery of mutations in genes encoding protein kinase PTEN‐induced kinase 1 (PINK1) and E3 ubiquitin ligase Parkin in familial Parkinson's disease and…”
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Expanding insights of mitochondrial dysfunction in Parkinson's disease by Wood, Nicholas W, Abou-Sleiman, Patrick M, Muqit, Miratul M. K

“…The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily influenced by the genes associated with the disease. The…”
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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 by Valente, Enza Maria, Abou-Sleiman, Patrick M., Caputo, Viviana, Miratul M. K. Muqit, Harvey, Kirsten, Gispert, Suzana, Ali, Zeeshan, Del Turco, Domenico, Bentivoglio, Anna Rita, Healy, Daniel G., Albanese, Alberto, Nussbaum, Robert, González-Maldonado, Rafael, Deller, Thomas, Salvi, Sergio, Cortelli, Pietro, Gilks, William P., Latchman, David S., Harvey, Robert J., Dallapiccola, Bruno, Auburger, Georg, Wood, Nicholas W.

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. We previously mapped a…”
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 by Kondapalli, Chandana, Kazlauskaite, Agne, Zhang, Ning, Woodroof, Helen I., Campbell, David G., Gourlay, Robert, Burchell, Lynn, Walden, Helen, Macartney, Thomas J., Deak, Maria, Knebel, Axel, Alessi, Dario R., Muqit, Miratul M. K.

“…Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that…”
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Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization by Osgerby, Laura, Lai, Yu-Chiang, Thornton, Peter J, Amalfitano, Joseph, Le Duff, Cécile S, Jabeen, Iqra, Kadri, Hachemi, Miccoli, Ageo, Tucker, James H. R, Muqit, Miratul M. K, Mehellou, Youcef

“…Since loss of function mutations of PINK1 lead to early onset Parkinson’s disease, there has been growing interest in the discovery of small molecules that…”
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Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans by Lenka, Dipti Ranjan, Dahe, Shakti Virendra, Antico, Odetta, Sahoo, Pritiranjan, Prescott, Alan R, Muqit, Miratul M K, Kumar, Atul

“…Loss-of-function Parkin mutations lead to early-onset of Parkinson's disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation…”
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Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity by Kazlauskaite, Agne, Kelly, Van, Johnson, Clare, Baillie, Carla, Hastie, C. James, Peggie, Mark, Macartney, Thomas, Woodroof, Helen I., Alessi, Dario R., Pedrioli, Patrick G. A., Muqit, Miratul M. K.

“…Mutations in PINK1 and Parkin are associated with early-onset Parkinson's disease. We recently discovered that PINK1 phosphorylates Parkin at serine65 (Ser65)…”
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A heterozygous effect for PINK1 mutations in Parkinson's disease? by Abou-Sleiman, Patrick M., Muqit, Miratul M. K., McDonald, Neil Q., Yang, Yan Xiang, Gandhi, Sonia, Healy, Daniel G., Harvey, Kirsten, Harvey, Robert J., Deas, Emma, Bhatia, Kailash, Quinn, Niall, Lees, Andrew, Latchman, David S., Wood, Nicholas W.

“…Objective To investigate the significance of PINK1 mutations in sporadic Parkinson's disease (PD). Methods We determined the frequency of PINK1 mutations by…”
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TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency by Flinn, Laura J., Keatinge, Marcus, Bretaud, Sandrine, Mortiboys, Heather, Matsui, Hideaki, De Felice, Elena, Woodroof, Helen I., Brown, Lucy, McTighe, Aimee, Soellner, Rosemarie, Allen, Claire E., Heath, Paul R., Milo, Marta, Muqit, Miratul M. K., Reichert, Andreas S., Köster, Reinhard W., Ingham, Philip W., Bandmann, Oliver

“…Objective Loss of function mutations in PINK1 typically lead to early onset Parkinson disease (PD). Zebrafish (Danio rerio) are emerging as a powerful new…”
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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress by Muqit, Miratul M. K., Abou‐Sleiman, Patrick M., Saurin, Adrian T., Harvey, Kirsten, Gandhi, Sonia, Deas, Emma, Eaton, Simon, Payne Smith, Martin D., Venner, Kerrie, Matilla, Antoni, Healy, Daniel G., Gilks, William P., Lees, Andrew J., Holton, Janice, Revesz, Tamas, Parker, Peter J., Harvey, Robert J., Wood, Nicholas W., Latchman, David S.

“…Following our identification of PTEN‐induced putative kinase 1 (PINK1) gene mutations in PARK6‐linked Parkinson's disease (PD), we have recently reported that…”
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The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons by Iovino, Mariangela, Pfisterer, Ulrich, Holton, Janice L., Lashley, Tammaryn, Swingler, Robert J., Calo, Laura, Treacy, Rebecca, Revesz, Tamas, Parmar, Malin, Goedert, Michel, Muqit, Miratul M. K., Spillantini, Maria Grazia

“…Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language…”
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Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog by Rogerson, Daniel T, Sachdeva, Amit, Wang, Kaihang, Haq, Tamanna, Kazlauskaite, Agne, Hancock, Susan M, Huguenin-Dezot, Nicolas, Muqit, Miratul M K, Fry, Andrew M, Bayliss, Richard, Chin, Jason W

“…A newly engineered phosphoserine synthetase/tRNA pair allows quantitative insertion of phosphoserine or, when coupled with metabolic rewiring, a…”
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mito-QC illuminates mitophagy and mitochondrial architecture in vivo by McWilliams, Thomas G, Prescott, Alan R, Allen, George F G, Tamjar, Jevgenia, Munson, Michael J, Thomson, Calum, Muqit, Miratul M K, Ganley, Ian G

“…Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential quality-control (QC) mechanism of pathophysiological relevance in…”
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Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations by Woodroof, Helen I., Pogson, Joe H., Begley, Mike, Cantley, Lewis C., Deak, Maria, Campbell, David G., van Aalten, Daan M. F., Whitworth, Alexander J., Alessi, Dario R., Muqit, Miratul M. K.

“…Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-recessive Parkinson's disease. To date, little is…”
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Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation by Pao, Kuan-Chuan, Stanley, Mathew, Han, Cong, Lai, Yu-Chiang, Murphy, Paul, Balk, Kristin, Wood, Nicola T, Corti, Olga, Corvol, Jean-Christophe, Muqit, Miratul M K, Virdee, Satpal

“…Probes of E3 ligase transthiolation activity reveal the hierarchy of phosphorylation events leading to cellular parkin activation and show that disease-linked…”
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PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72 by Vieweg, Sophie, Mulholland, Katie, Bräuning, Bastian, Kachariya, Nitin, Lai, Yu-Chiang, Toth, Rachel, Singh, Pawan Kishor, Volpi, Ilaria, Sattler, Michael, Groll, Michael, Itzen, Aymelt, Muqit, Miratul M K

“…Loss of function mutations in the PTEN-induced kinase 1 (PINK1) kinase are causal for autosomal recessive Parkinson's disease (PD) whilst gain of function…”
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The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1 by Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef, Muqit, Miratul M. K.

“…Mutations in PINK1, which impair its catalytic kinase activity, are causal for autosomal recessive early‐onset Parkinson's disease (PD). Various studies have…”
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation by Kazlauskaite, Agne, Martínez-Torres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan MF, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul MK

“…Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that…”
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UCHL-1 is not a Parkinson's disease susceptibility gene by Healy, Daniel G., Abou-Sleiman, Patrick M., Casas, Juan P., Ahmadi, Kourosh R., Lynch, Timothy, Gandhi, Sonia, Muqit, Miratul M. K., Foltynie, Thomas, Barker, Roger, Bhatia, Kailash P., Quinn, Niall P., Lees, Andrew J., Gibson, J. Mark, Holton, Janice L., Revesz, Tamas, Goldstein, David B., Wood, Nicholas W.

“…Objective The UCHL‐1 gene is widely cited as a susceptibility factor for sporadic Parkinson's disease (PD). The strongest evidence comes from a meta‐analysis…”
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Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies? by Kunath, Tilo, Natalwala, Ammar, Chan, Claire, Chen, Yixi, Stecher, Benjamin, Taylor, Martin, Khan, Sadaquate, Muqit, Miratul M. K.

“…Parkinson's is a heterogeneous, complex condition. Stratification of Parkinson's subtypes will be essential to identify those that will benefit most from a…”
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