Search Results - "Miranti, Cindy K"

The importance of non-nuclear AR signaling in prostate cancer progression and therapeutic resistance by Zarif, Jelani C., Miranti, Cindy K.

“…The androgen receptor (AR) remains the major oncogenic driver of prostate cancer, as evidenced by the efficacy of androgen deprivation therapy (ADT) in naïve…”
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Microfluidic Applications in Prostate Cancer Research by Szewczyk, Kailie, Jiang, Linan, Khawaja, Hunain, Miranti, Cindy K, Zohar, Yitshak

“…Prostate cancer is a disease in which cells in the prostate, a gland in the male reproductive system below the bladder, grow out of control and, among men, it…”
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Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC by Frank, Sander B, Berger, Penny L, Ljungman, Mats, Miranti, Cindy K

“…Many pathways dysregulated in prostate cancer are also involved in epithelial differentiation. To better understand prostate tumor initiation, we sought to…”
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Microfluidic-based human prostate-cancer-on-chip by Jiang, Linan, Khawaja, Hunain, Tahsin, Shekha, Clarkson, Tanjia A, Miranti, Cindy K, Zohar, Yitshak

“…Lack of adequate models significantly hinders advances in prostate cancer treatment, where resistance to androgen-deprivation therapies and bone metastasis…”
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Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1 by Tesfay, Lia, Schulz, Veronique V, Frank, Sander B, Lamb, Laura E, Miranti, Cindy K

“…Matrix adhesion via integrins is required for cell survival. Adhesion of epithelial cells to laminin via integrin α3β1 was previously shown to activate at…”
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The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis by Ganguly, Sourik S, Li, Xiaohong, Miranti, Cindy K

“…Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa deaths are due to osteoblastic bone metastases. What triggers PCa…”
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Disruption of prostate epithelial differentiation pathways and prostate cancer development by Frank, Sander B, Miranti, Cindy K

“…One of the foremost problems in the prostate cancer (PCa) field is the inability to distinguish aggressive from indolent disease, which leads to difficult…”
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Epidermal Growth Factor Receptor-Dependent Regulation of Integrin-Mediated Signaling and Cell Cycle Entry in Epithelial Cells by Bill, Heather M., Knudsen, Beatrice, Moores, Sheri L., Muthuswamy, Senthil K., Rao, Vikram R., Brugge, Joan S., Miranti, Cindy K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism by Xia, Zhengui, Dudek, Henryk, Miranti, Cindy K, Greenberg, Michael E

“…The regulation of gene expression by neurotransmitters is likely to play a key role in neuroplasticity both during development and in the adult animal…”
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Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82 by Bergsma, Alexis, Ganguly, Sourik S, Wiegand, Mollie E, Dick, Daniel, Williams, Bart O, Miranti, Cindy K

“…We used a myeloid-specific Cre to conditionally delete CD82 in mouse osteoclasts and their precursors. In contrast to global loss of CD82 (gKO), conditional…”
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Overexpression of sprouty 2 inhibits HGF SF-mediated cell growth, invasion, migration, and cytokinesis by LEE, Chong-Chou, PUTNAM, Andrew J, MIRANTI, Cindy K, GUSTAFSON, Margaret, WANG, Ling-Mei, VANDE WOUDE, George F, GAO, Chong-Feng

“…A strict regulation of hepatocyte growth factor/scatter factor (HGF/SF)-Met signaling is essential for its appropriate function. Several negative regulators of…”
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Correction: AR loss in prostate cancer stroma mediated by NF-κB and p38-MAPK signaling disrupts stromal morphogen production by Tahsin, Shekha, Sane, Neha S., Cernyar, Brent, Jiang, Linan, Zohar, Yitshak, Lee, Benjamin R., Miranti, Cindy K.

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AR loss in prostate cancer stroma mediated by NF-κB and p38-MAPK signaling disrupts stromal morphogen production by Tahsin, Shekha, Sane, Neha S., Cernyar, Brent, Jiang, Linan, Zohar, Yitshak, Lee, Benjamin R., Miranti, Cindy K.

“…Androgen Receptor (AR) activity in prostate stroma is required to maintain prostate homeostasis. This is mediated through androgen-dependent induction and…”
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Hepcidin regulation in prostate and its disruption in prostate cancer by Tesfay, Lia, Clausen, Kathryn A, Kim, Jin Woo, Hegde, Poornima, Wang, Xiaohong, Miller, Lance D, Deng, Zhiyong, Blanchette, Nicole, Arvedson, Tara, Miranti, Cindy K, Babitt, Jodie L, Lin, Herbert Y, Peehl, Donna M, Torti, Frank M, Torti, Suzy V

“…Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling. Here, we report that prostate…”
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Cancer Cell–Extrinsic Roles for the Androgen Receptor in Prostate Cancer by Hahn, Andrew W, Siddiqui, Bilal A, Leo, Javier, Dondossola, Eleonora, Basham, Kaitlin J, Miranti, Cindy K, Frigo, Daniel E

“…Abstract Given the central role of the androgen receptor (AR) in prostate cancer cell biology, AR-targeted therapies have been the backbone of prostate cancer…”
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Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer by Nollet, Eric A., Cardo-Vila, Marina, Ganguly, Sourik S., Tran, Jack D., Schulz, Veronique V., Cress, Anne, Corey, Eva, Miranti, Cindy K.

“…The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration-resistant disease…”
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A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector by Frank, Sander B, Schulz, Veronique V, Miranti, Cindy K

“…Short hairpin RNA (shRNA) is an established and effective tool for stable knock down of gene expression. Lentiviral vectors can be used to deliver shRNAs,…”
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Notch3 promotes prostate cancer-induced bone lesion development via MMP-3 by Ganguly, Sourik S., Hostetter, Galen, Tang, Lin, Frank, Sander B., Saboda, Kathylynn, Mehra, Rohit, Wang, Lisha, Li, Xiaohong, Keller, Evan T., Miranti, Cindy K.

“…Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with…”
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Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors by Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A.

“…Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive…”
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Sensing the environment: a historical perspective on integrin signal transduction by Brugge, Joan S, Miranti, Cindy K

“…Cell adhesion mediated by integrin receptors has a critical function in organizing cells in tissues and in guiding haematopoietic cells to their sites of…”
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