Search Results - "Miranda, Noel F. C. C."

The Variable Genomic Landscape During Osteosarcoma Progression: Insights From a Longitudinal WGS Analysis by Meijer, Debora M., Ruano, Dina, Briaire‐de Bruijn, Inge H., Wijers‐Koster, Pauline M., Sande, Michiel A. J., Gelderblom, Hans, Cleton‐Jansen, Anne‐Marie, Miranda, Noel F. C. C., Kuijjer, Marieke L., Bovée, Judith V. M. G.

“…ABSTRACT Osteosarcoma is a primary bone tumor that exhibits a complex genomic landscape characterized by gross chromosomal abnormalities. Osteosarcoma patients…”
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Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4 by van den Bulk, Jitske, Verdegaal, Els M E, Ruano, Dina, Ijsselsteijn, Marieke E, Visser, Marten, van der Breggen, Ruud, Duhen, Thomas, van der Ploeg, Manon, de Vries, Natasja L, Oosting, Jan, Peeters, Koen C M J, Weinberg, Andrew D, Farina-Sarasqueta, Arantza, van der Burg, Sjoerd H, de Miranda, Noel F C C

“…The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch…”
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PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors by Beyrend, Guillaume, van der Gracht, Esmé, Yilmaz, Ayse, van Duikeren, Suzanne, Camps, Marcel, Höllt, Thomas, Vilanova, Anna, van Unen, Vincent, Koning, Frits, de Miranda, Noel F C C, Arens, Ramon, Ossendorp, Ferry

“…The clinical benefit of immunotherapeutic approaches against cancer has been well established although complete responses are only observed in a minority of…”
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Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients by Kenkhuis, Boyd, Somarakis, Antonios, de Haan, Lorraine, Dzyubachyk, Oleh, IJsselsteijn, Marieke E, de Miranda, Noel F C C, Lelieveldt, Boudewijn P F, Dijkstra, Jouke, van Roon-Mom, Willeke M C, Höllt, Thomas, van der Weerd, Louise

“…Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown…”
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Mismatch repair deficiency is rare in bone and soft tissue tumors by Lam, Suk Wai, Kostine, Marie, Miranda, Noel F C C, Schöffski, Patrick, Lee, Che‐Jui, Morreau, Hans, Bovée, Judith V M G

“…Introduction There has been an increased demand for mismatch repair (MMR) status testing in sarcoma patients after the success of immune checkpoint inhibition…”
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Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data by Ijsselsteijn, Marieke E., Somarakis, Antonios, Lelieveldt, Boudewijn P. F., Höllt, Thomas, Miranda, Noel F. C. C.

“…Imaging mass cytometry (IMC) allows the detection of multiple antigens (approximately 40 markers) combined with spatial information, making it a unique tool…”
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Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation by Guo, Nannan, Li, Na, Jia, Li, Jiang, Qinyue, Schreurs, Mette, van Unen, Vincent, de Sousa Lopes, Susana M. Chuva, Vloemans, Alexandra A., Eggermont, Jeroen, Lelieveldt, Boudewijn, Staal, Frank J. T., de Miranda, Noel F. C. C., Pascutti, M. Fernanda, Koning, Frits

“…The intestine represents the largest immune compartment in the human body, yet its development and organisation during human foetal development is largely…”
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Germline variant affecting p53β isoforms predisposes to familial cancer by Schubert, Stephanie A., Ruano, Dina, Joruiz, Sebastien M., Stroosma, Jordy, Glavak, Nikolina, Montali, Anna, Pinto, Lia M., Rodríguez-Girondo, Mar, Barge-Schaapveld, Daniela Q. C. M., Nielsen, Maartje, van Nesselrooij, Bernadette P. M., Mensenkamp, Arjen R., van Leerdam, Monique E., Sharp, Thomas H., Morreau, Hans, Bourdon, Jean-Christophe, de Miranda, Noel F. C. C., van Wezel, Tom

“…Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53…”
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Digenic inheritance of MSH6 and MUTYH variants in familial colorectal cancer by Schubert, Stephanie A., Ruano, Dina, Tiersma, Yvonne, Drost, Mark, Wind, Niels, Nielsen, Maartje, Hest, Liselotte P., Morreau, Hans, Miranda, Noel F. C. C., Wezel, Tom

“…We describe a family severely affected by colorectal cancer (CRC) where whole‐exome sequencing identified the coinheritance of the germline variants encoding…”
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The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer by Trimaglio, Giulia, Sneperger, Tamara, Raymond, Benjamin B. A., Gilles, Nelly, Näser, Emmanuelle, Locard-Paulet, Marie, Ijsselsteijn, Marieke E., Brouwer, Thomas P., Ecalard, Romain, Roelands, Jessica, Matsumoto, Naoki, Colom, André, Habch, Myriam, de Miranda, Noel F. C. C., Vergnolle, Nathalie, Devaud, Christel, Neyrolles, Olivier, Rombouts, Yoann

“…Development and progression of malignancies are accompanied and influenced by alterations in the surrounding immune microenvironment. Understanding the…”
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Mass Cytometric Analysis of Early-Stage Mycosis Fungoides by Guo, Nannan, Jia, Li, Out-Luiting, Coby, Miranda, Noel F C C de, Willemze, Rein, Koning, Frits, Vermeer, Maarten, Quint, Koen

“…Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. Early-stage disease is characterized by superficial infiltrates of small- to…”
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A pre‐existing coordinated inflammatory microenvironment is associated with complete response of vulvar high‐grade squamous intraepithelial lesions to different forms of immunotherapy by Abdulrahman, Ziena, Miranda, Noel F. C. C., Hellebrekers, Bart W. J., Vos van Steenwijk, Peggy J., Esch, Edith M. G., Burg, Sjoerd H., Poelgeest, Mariette I. E.

“…Immunotherapy of vulvar high‐grade squamous intraepithelial lesion (vHSIL) is investigated as an alternative for surgery, because of high comorbidity and risk…”
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Advancing cancer immunotherapy: a vision for the field by de Miranda, Noel F C C, Trajanoski, Zlatko

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Advancing multiplexed imaging for enhanced tissue complexity analysis by Ijsselsteijn, Marieke E., de Miranda, Noel F. C. C.

“…Multiplexed spatial immunophenotyping has advanced our understanding of tissues in the context of homeostasis and disease. Two studies now provide additional…”
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Memory CD4+ T cells are generated in the human fetal intestine by Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin, McLaren, James E., Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F. C. C., Chudakov, Dmitriy M., Price, David A., Lelieveldt, Boudewijn P. F., Koning, Frits

“…The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO + T cells reside in the fetal intestine. Here we combined functional assays…”
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Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling by Nunes, Joana B., Ijsselsteijn, Marieke E., Abdelaal, Tamim, Ursem, Rick, van der Ploeg, Manon, Giera, Martin, Everts, Bart, Mahfouz, Ahmed, Heijs, Bram, de Miranda, Noel F. C. C.

“…The integration of spatial omics technologies can provide important insights into the biology of tissues. Here we combined mass spectrometry imaging-based…”
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Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial by Verschoor, Yara L., van de Haar, Joris, van den Berg, José G., van Sandick, Johanna W., Kodach, Liudmila L., van Dieren, Jolanda M., Balduzzi, Sara, Grootscholten, Cecile, IJsselsteijn, Marieke E., Veenhof, Alexander A. F. A., Hartemink, Koen J., Vollebergh, Marieke A., Jurdi, Adham, Sharma, Shruti, Spickard, Erik, Owers, Emilia C., Bartels-Rutten, Annemarieke, den Hartog, Peggy, de Miranda, Noel F. C. C., van Leerdam, Monique E., Haanen, John B. A. G., Schumacher, Ton N., Voest, Emile E., Chalabi, Myriam

“…Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite recent advancements, most patients die of their disease. Although…”
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Germline NPAT inactivating variants as cause of hereditary colorectal cancer by Terradas, Mariona, Schubert, Stephanie A, Viana-Errasti, Julen, Ruano, Dina, Aiza, Gemma, Nielsen, Maartje, Marciel, Paula, Tops, Carli M, Parra, Genís, Morreau, Hans, Torrents, David, van Leerdam, Monique E, Capellá, Gabriel, de Miranda, Noel F C C, Valle, Laura, van Wezel, Tom

“…Two independent exome sequencing initiatives aimed to identify new genes involved in the predisposition to nonpolyposis colorectal cancer led to the…”
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Author Correction: Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial by Verschoor, Yara L., van de Haar, Joris, van den Berg, José G., van Sandick, Johanna W., Kodach, Liudmila L., van Dieren, Jolanda M., Balduzzi, Sara, Grootscholten, Cecile, IJsselsteijn, Marieke E., Veenhof, Alexander A. F. A., Hartemink, Koen J., Vollebergh, Marieke A., Jurdi, Adham, Sharma, Shruti, Spickard, Erik, Owers, Emilia C., Bartels-Rutten, Annemarieke, den Hartog, Peggy, de Miranda, Noel F. C. C., van Leerdam, Monique E., Haanen, John B. A. G., Schumacher, Ton N., Voest, Emile E., Chalabi, Myriam

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Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model by Kumar, Sumit, Schoonderwoerd, Mark J A, Kroonen, Jessie S, de Graaf, Ilona J, Sluijter, Marjolein, Ruano, Dina, González-Prieto, Román, Verlaan-de Vries, Matty, Rip, Jasper, Arens, Ramon, de Miranda, Noel F C C, Hawinkels, Lukas J A C, van Hall, Thorbald, Vertegaal, Alfred C O

“…Pancreatic ductal adenocarcinoma (PDAC) has the characteristics of high-density desmoplastic stroma, a distinctive immunosuppressive microenvironment and is…”
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