Search Results - "Miranda, Miguel A."
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Scope and limitations of the TEMPO/EPR method for singlet oxygen detection: the misleading role of electron transfer
Published in Free radical biology & medicine (01-12-2014)“…For many biological and biomedical studies, it is essential to detect the production of 1O2 and quantify its production yield. Among the available methods,…”
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2
Organic Photocatalysts for the Oxidation of Pollutants and Model Compounds
Published in Chemical reviews (14-03-2012)“…A study examined the oxidation of pollutants with organic photocatalysts, focusing on the biodegradation methods and alternatives. Some of these alternatives…”
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3
Lymphatic territories (lymphosomes) in a canine: an animal model for investigation of postoperative lymphatic alterations
Published in PloS one (24-07-2013)“…Lymph node dissection is often performed as a part of surgical treatment for breast cancer and malignant melanoma to prevent malignant cells from traveling via…”
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4
Metal‐Free Photocatalytic Reductive Dehalogenation Using Visible‐Light: A Time‐Resolved Mechanistic Study
Published in European journal of organic chemistry (18-04-2017)“…The reductive dehalogenation of organic bromides has been achieved in the presence of riboflavin (RF) as photocatalyst under visible‐light irradiation…”
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5
Theoretical Study on the Photo-Oxidation and Photoreduction of an Azetidine Derivative as a Model of DNA Repair
Published in Molecules (Basel, Switzerland) (14-05-2021)“…Photocycloreversion plays a central role in the study of the repair of DNA lesions, reverting them into the original pyrimidine nucleobases. Particularly,…”
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6
Seasonal and Nocturnal Activity of Culicoides spp. (Diptera: Ceratopogonidae) Adapted to Different Environments in the Balearic Islands
Published in Diversity (Basel) (20-05-2023)“…Several pathogens are known to be transmitted by arthropods. One of the most relevant, in economic terms, affecting animals is bluetongue virus. Its known…”
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Cellular photo(geno)toxicity of gefitinib after biotransformation
Published in Frontiers in pharmacology (07-06-2023)“…Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer…”
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8
Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses
Published in The Journal of clinical investigation (01-09-2022)“…Immune checkpoint blockade (ICB) has demonstrated clinical success in "inflamed" tumors with substantial T cell infiltrates, but tumors with an immune-desert…”
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Sunscreen-Based Photocages for Topical Drugs: A Photophysical and Photochemical Study of A Diclofenac-Avobenzone Dyad
Published in Molecules (Basel, Switzerland) (16-03-2018)“…Photosensitization by drugs is a problem of increasing importance in modern life. This phenomenon occurs when a chemical substance in the skin is exposed to…”
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10
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer
Published in Nature communications (07-03-2022)“…Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis and is a major challenge to current treatments. Cancer cells…”
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PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
Published in Cancer discovery (02-09-2022)“…Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this complex in PRC2-dependent…”
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12
Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins
Published in Frontiers in pharmacology (16-05-2024)“…The photobiological damage that certain drugs or their metabolites can photosensitize in proteins is generally associated with the nature of the excited…”
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13
Modulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols
Published in Molecules (Basel, Switzerland) (12-02-2022)“…Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of…”
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14
A Three-Pronged Approach to Studying Sublethal Insecticide Doses: Characterising Mosquito Fitness, Mosquito Biting Behaviour, and Human/Environmental Health Risks
Published in Insects (Basel, Switzerland) (11-06-2021)“…Worldwide, pyrethroids are one of the most widely used insecticide classes. In addition to serving as personal protection products, they are also a key line of…”
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15
Environmentally sensitive fluorescence of the topical retinoid adapalene
Published in Frontiers in chemistry (08-07-2024)“…Intrinsic fluorescence of drugs brings valuable information on their localization in the organism and their interaction with key biomolecules. In this work, we…”
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Enhanced Photodegradation of Synthetic Dyes Mediated by Ag3PO4-Based Semiconductors under Visible Light Irradiation
Published in Catalysts (01-07-2020)“…Four silver phosphate-based materials were successfully synthesized, characterized, and evaluated, together with TiO2, in the photodegradation of synthetic…”
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Synthesis and Chemiluminescent Properties of Amino-Acylated luminol Derivatives Bearing Phosphonium Cations
Published in Molecules (Basel, Switzerland) (31-10-2019)“…The monitoring of reactive oxygen species in living cells provides valuable information on cell function and performance. Lately, the development of…”
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Repair of a Dimeric Azetidine Related to the Thymine-Cytosine (6-4) Photoproduct by Electron Transfer Photoreduction
Published in Angewandte Chemie International Edition (10-05-2016)“…Photolyases are intriguing enzymes that take advantage of sunlight to restore lesions like cyclobutane pyrimidine dimers or (6‐4) photoproducts. This work…”
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Protein Binding of Lapatinib and Its N- and O-Dealkylated Metabolites Interrogated by Fluorescence, Ultrafast Spectroscopy and Molecular Dynamics Simulations
Published in Frontiers in pharmacology (30-10-2020)“…Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological…”
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Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse
Published in Angewandte Chemie International Edition (17-06-2013)“…A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5‐methyl‐2‐pyrimidone (see picture), the main chromophore…”
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