Search Results - "Miranda, Marcelo Coutinho de"
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Extracellular Vesicles from Adipose-Derived Mesenchymal Stem/Stromal Cells Accelerate Migration and Activate AKT Pathway in Human Keratinocytes and Fibroblasts Independently of miR-205 Activity
Published in Stem cells international (01-01-2017)“…Mesenchymal stem/stromal cells (MSCs) are promising tools in cell therapy. They secrete extracellular vesicles (EVs) that carry different classes of molecules…”
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Neuroprotective Effect of siRNA Entrapped in Hyaluronic Acid-Coated Lipoplexes by Intravitreal Administration
Published in Pharmaceutics (08-06-2021)“…Since the possibility of silencing specific genes linked to retinal degeneration has become a reality with the use of small interfering RNAs (siRNAs), this…”
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Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model
Published in Biomedicine & pharmacotherapy (01-10-2019)“…Long circulating pH-sensitive liposomes have been shown to effectively deliver doxorubicin (DOX) to tumors and reduce its toxic effects. Folic acid receptors…”
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Selection of internalizing RNA aptamers into human breast cancer cells derived from primary sites
Published in Journal of cellular biochemistry (01-04-2024)“…Breast cancer is the most common cancer in women. Although chemotherapy is still broadly used in its treatment, adverse effects remain a challenge. In this…”
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Development of a membrane and a bilayer of chitosan, gelatin, and polyhydroxybutyrate to be used as wound dressing for the regeneration of rat excisional wounds
Published in Journal of biomedical materials research. Part A (01-01-2024)“…The skin is the largest organ in the human body that acts as a protective barrier from the outside environment. Certain dermatological pathologies or…”
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Cobalt‐containing bioactive glass mimics vascular endothelial growth factor A and hypoxia inducible factor 1 function
Published in Journal of biomedical materials research. Part A (01-07-2021)“…Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with…”
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Roles of mesenchymal stromal cells in the head and neck cancer microenvironment
Published in Biomedicine & pharmacotherapy (01-12-2021)“…Head and neck cancer (HNC), a common malignancy worldwide, is associated with high morbidity and mortality rates. Squamous cell carcinoma is the most common…”
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Protection of normal cells from irradiation bystander effects by silica-flufenamic acid nanoparticles
Published in Journal of materials science. Materials in medicine (01-08-2018)“…The development of a myriad of nanoparticles types has opened new possibilities for the diagnostics and treatment of many diseases, especially for cancer…”
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Selection of DNA Aptamers for Differentiation of Human Adipose-Derived Mesenchymal Stem Cells from Fibroblasts
Published in Applied biochemistry and biotechnology (01-11-2021)“…In recent years, stem cell therapy has shown promise in regenerative medicine. The lack of standardized protocols for cell isolation and differentiation…”
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Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance
Published in Science advances (01-12-2023)“…Cancer stem cells (CSCs) drive tumor growth, metastasis, and chemoresistance. While emerging evidence suggests that CSCs have a unique dependency on lipid…”
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Translocation of Epidermal Growth Factor (EGF) to the nucleus has distinct kinetics between adipose tissue-derived mesenchymal stem cells and a mesenchymal cancer cell lineage
Published in Journal of structural biology (01-04-2018)“…Nuclear Epidermal Growth Factor Receptor (EGFR) has been associated with worse prognosis and treatment resistance for several cancer types. After Epidermal…”
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Glyphosate-based herbicide induces toxic effects on human adipose-derived mesenchymal stem cells grown in human plasma
Published in Comparative clinical pathology (01-07-2018)“…Glyphosate (N-phosphonometil-glicine)-based formulations are herbicides widely used in world agriculture as well as in Brazilian territory. Therefore, it is…”
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The basis of nuclear phospholipase C in cell proliferation
Published in Advances in biological regulation (01-12-2021)“…Ca2+ is a highly versatile intracellular signal that regulates many biological processes such as cell death and proliferation. Broad Ca2+-signaling machinery…”
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Adipose-derived stem/stromal cell secretome modulates breast cancer cell proliferation and differentiation state towards aggressiveness
Published in Biochimie (01-12-2021)“…It is becoming increasingly evident that mesenchymal stem/stromal cells are recruited by cancer cells from nearby endogenous host stroma and promote events…”
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Phospholipase C delta 4 (PLCδ4) is a nuclear protein involved in cell proliferation and senescence in mesenchymal stromal stem cells
Published in Cellular signalling (01-09-2018)“…Ca2+ is an important second messenger, and it is involved in many cellular processes such as cell death and proliferation. The rise in intracellular Ca2+…”
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Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4)
Published in The Journal of biological chemistry (08-11-2019)“…Calcium (Ca2+) signaling within the cell nucleus regulates specific cellular events such as gene transcription and cell proliferation. Nuclear and cytosolic…”
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Human adipose‐derived stromal/stem cells are distinct from dermal fibroblasts as evaluated by biological characterization and RNA sequencing
Published in Cell biochemistry and function (01-04-2021)“…Human adipose‐derived stromal/stem cells (ASC) have immunomodulatory properties and the potential to differentiate into several cell lines, important for…”
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