Search Results - "Miralles, Raquel M"

Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy by Thompson, Jeremy A., Miralles, Raquel M., Wengert, Eric R., Wagley, Pravin K., Yu, Wenxi, Wenker, Ian C., Patel, Manoj K.

“…Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain‐of‐function mutations in the voltage‐gated sodium channel Nav1.6. The disorder…”
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Somatostatin-Positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy by Wengert, Eric R, Miralles, Raquel M, Wedgwood, Kyle C A, Wagley, Pravin K, Strohm, Samantha M, Panchal, Payal S, Idrissi, Abrar Majidi, Wenker, Ian C, Thompson, Jeremy A, Gaykema, Ronald P, Patel, Manoj K

“…epileptic encephalopathy is a devastating epilepsy syndrome caused by mutant , which encodes the voltage-gated sodium channel Na 1.6. To date, it is unclear if…”
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It Takes Two to Tango: Channel Interplay Leads to Paradoxical Hyperexcitability in a Loss-of-Function Epilepsy Variant by Miralles, Raquel M., Patel, Manoj K.

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Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy by Miralles, Raquel M, Boscia, Alexis R, Kittur, Shrinidhi, Hanflink, Jessica C, Panchal, Payal S, Yorek, Matthew S, Deutsch, Tyler C J, Reever, Caeley M, Vundela, Shreya R, Wengert, Eric R, Patel, Manoj K

“…SCN8A developmental and epileptic encephalopathy (DEE) is a severe epilepsy syndrome resulting from mutations in the voltage-gated sodium channel Nav1.6,…”
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