Search Results - "Miraglia, Loren J."

SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel by Qiu, Zhaozhu, Dubin, Adrienne E, Mathur, Jayanti, Tu, Buu, Reddy, Kritika, Miraglia, Loren J, Reinhardt, Jürgen, Orth, Anthony P, Patapoutian, Ardem

“…Maintenance of a constant cell volume in response to extracellular or intracellular osmotic changes is critical for cellular homeostasis. Activation of a…”
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Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets by Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

“…A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the…”
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A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells by Zhang, Eric E., Liu, Andrew C., Hirota, Tsuyoshi, Miraglia, Loren J., Welch, Genevieve, Pongsawakul, Pagkapol Y., Liu, Xianzhong, Atwood, Ann, Huss, Jon W., Janes, Jeff, Su, Andrew I., Hogenesch, John B., Kay, Steve A.

“…Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify…”
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A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock by Sato, Trey K., Panda, Satchidananda, Miraglia, Loren J., Reyes, Teresa M., Rudic, Radu D., McNamara, Peter, Naik, Kinnery A., FitzGerald, Garret A., Kay, Steve A., Hogenesch, John B.

“…The mammalian circadian clock plays an integral role in timing rhythmic physiology and behavior, such as locomotor activity, with anticipated daily…”
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Tumor suppressor protein (p)53, is a regulator of NF-κB repression by the glucocorticoid receptor by Murphy, Samantha H, Suzuki, Kotaro, Downes, Michael, Welch, Genevieve L, De Jesus, Paul, Miraglia, Loren J, Orth, Anthony P, Chanda, Sumit K, Evans, Ronald M, Verma, Inder M

“…Glucocorticoids can inhibit inflammation by abrogating the activity of NF-κB, a family of transcription factors that regulates the production of…”
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Seeing the light: luminescent reporter gene assays by Miraglia, Loren J, King, Frederick J, Damoiseaux, Robert

“…The luminescent reporter gene assay (LRGA) is arguably the most prominent type of reporter gene assay used in biomolecular and pharmaceutical development…”
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coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway by Amelio, Antonio L, Miraglia, Loren J, Conkright, Juliana J, Mercer, Becky A, Batalov, Serge, Cavett, Valerie, Orth, Anthony P, Busby, Jennifer, Hogenesch, John B, Conkright, Michael D

“…Signal transduction pathways often use a transcriptional component to mediate adaptive cellular responses. Coactivator proteins function prominently in these…”
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Cofactors Required for TLR7- and TLR9-Dependent Innate Immune Responses by Chiang, Chih-yuan, Engel, Alex, Opaluch, Amanda M., Ramos, Irene, Maestre, Ana M., Secundino, Ismael, De Jesus, Paul D., Nguyen, Quy T., Welch, Genevieve, Bonamy, Ghislain M.C., Miraglia, Loren J., Orth, Anthony P., Nizet, Victor, Fernandez-Sesma, Ana, Zhou, Yingyao, Barton, Gregory M., Chanda, Sumit K.

“…Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded…”
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role for IκB kinase 2 in bipolar spindle assembly by Irelan, Jeffrey T, Murphy, Thomas J, DeJesus, Paul D, Teo, Hsiangling, Xu, DingYue, Gomez-Ferreria, Maria A, Zhou, Yingyao, Miraglia, Loren J, Rines, Daniel R, Verma, Inder M, Sharp, David J, Tergaonkar, Vinay, Chanda, Sumit K

“…IκB kinase 2 (IKK2 or IKKβ) is a component of the IKK complex that coordinates the cellular response to a diverse set of extracellular stimuli, including…”
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A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms by Zhou, Lili, Miller, Caitlyn, Miraglia, Loren J., Romero, Angelica, Mure, Ludovic S., Panda, Satchidananda, Kay, Steve A.

“…The regulatory mechanisms of circadian rhythms have been studied primarily at the level of the transcription–translation feedback loops of protein-coding…”
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Couto, Joana Pinto, Brinkhaus, Heike, Koren, Shany, De Silva, Duvini, Mertz, Kirsten D., Kaup, Daniela, Varga, Zsuzsanna, Voshol, Hans, Vissieres, Alexandra, Leroy, Cedric, Roloff, Tim, Stadler, Michael B., Scheel, Christina H., Miraglia, Loren J., Orth, Anthony P., Bonamy, Ghislain M. C., Reddy, Venkateshwar A., Bentires-Alj, Mohamed

“…Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby…”
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Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells by Ting, Pamela Y., Parker, Albert E., Lee, J. Scott, Trussell, Chris, Sharif, Orzala, Luna, Fabio, Federe, Glenn, Barnes, S. Whitney, Walker, John R., Vance, Julie, Gao, Mu-Yun, Klock, Heath E., Clarkson, Scott, Russ, Carsten, Miraglia, Loren J., Cooke, Michael P., Boitano, Anthony E., McNamara, Peter, Lamb, John, Schmedt, Christian, Snead, Jennifer L.

“…CRISPR–Cas9 screening allows genome-wide interrogation of gene function. Currently, to achieve the high and uniform Cas9 expression desirable for screening,…”
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Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication by König, Renate, Zhou, Yingyao, Elleder, Daniel, Diamond, Tracy L., Bonamy, Ghislain M.C., Irelan, Jeffrey T., Chiang, Chih-yuan, Tu, Buu P., De Jesus, Paul D., Lilley, Caroline E., Seidel, Shannon, Opaluch, Amanda M., Caldwell, Jeremy S., Weitzman, Matthew D., Kuhen, Kelli L., Bandyopadhyay, Sourav, Ideker, Trey, Orth, Anthony P., Miraglia, Loren J., Bushman, Frederic D., Young, John A., Chanda, Sumit K.

“…Human Immunodeficiency Viruses (HIV-1 and HIV-2) rely upon host-encoded proteins to facilitate their replication. Here, we combined genome-wide siRNA analyses…”
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Feedback repression is required for mammalian circadian clock function by Ueda, Hiroki R, Hogenesch, John B, Sato, Trey K, Yamada, Rikuhiro G, Ukai, Hideki, Baggs, Julie E, Miraglia, Loren J, Kobayashi, Tetsuya J, Welsh, David K, Kay, Steve A

“…Direct evidence for the requirement of transcriptional feedback repression in circadian clock function has been elusive. Here, we developed a molecular genetic…”
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An RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation by Wurdak, Heiko, Zhu, Shoutian, Romero, Angelica, Lorger, Mihaela, Watson, James, Chiang, Chih-yuan, Zhang, Jay, Natu, Vanita S., Lairson, Luke L., Walker, John R., Trussell, Christopher M., Harsh, Griffith R., Vogel, Hannes, Felding-Habermann, Brunhilde, Orth, Anthony P., Miraglia, Loren J., Rines, Daniel R., Skirboll, Stephen L., Schultz, Peter G.

“…Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer associated with a very poor prognosis. Recently, the initiation and growth of GBM has…”
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Human RNase III Is a 160-kDa Protein Involved in Preribosomal RNA Processing by Wu, Hongjiang, Xu, Hong, Miraglia, Loren J., Crooke, Stanley T.

“…A human RNase III gene encodes a protein of 160 kDa with multiple domains, a proline-rich, a serine- and arginine-rich, and an RNase III domain. The expressed…”
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Protein kinase C delta is a prosurvival factor in human breast tumor cell lines by McCracken, Meredith A, Miraglia, Loren J, McKay, Robert A, Strobl, Jeannine S

“…Protein kinase C (PKC) promotes cell survival in response to ionizing radiation in a variety of experimental models including human carcinoma, human…”
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ER by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Couto, Joana Pinto, Brinkhaus, Heike, Koren, Shany, De Silva, Duvini, Mertz, Kirsten D, Kaup, Daniela, Varga, Zsuzsanna, Voshol, Hans, Vissieres, Alexandra, Leroy, Cedric, Roloff, Tim, Stadler, Michael B, Scheel, Christina H, Miraglia, Loren J, Orth, Anthony P, Bonamy, Ghislain M. C, Reddy, Venkateshwar A, Bentires-Alj, Mohamed

“…Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-[alpha], thereby…”
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Akt-mediated phosphorylation of Argonaute 2 down-regulates cleavage and up-regulates translational repression of microRNA targets by Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

“…A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the…”
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Tumor suppressor protein (p)53, is a regulator of NF-kgr;B repression by the glucocorticoid receptor by Murphy, Samantha H, Suzuki, Kotaro, Downes, Michael, Welch, Genevieve L, De Jesus, Paul, Miraglia, Loren J, Orth, Anthony P, Chanda, Sumit K, Evans, Ronald M, Verma, Inder M

“…Glucocorticoids can inhibit inflammation by abrogating the activity of NF-...B, a family of transcription factors that regulates the production of…”
Get full text