Search Results - "Miraghazadeh, Bahar"

Nuclear Factor-kappaB in Autoimmunity: Man and Mouse by Miraghazadeh, Bahar, Cook, Matthew C

“…NF-κB (nuclear factor-kappa B) is a transcription complex crucial for host defense mediated by innate and adaptive immunity, where canonical NF-κB signaling,…”
Get full text

Gain-of-function IKBKB mutation causes human combined immune deficiency by Cardinez, Chelisa, Miraghazadeh, Bahar, Tanita, Kay, da Silva, Elizabeth, Hoshino, Akihiro, Okada, Satoshi, Chand, Rochna, Asano, Takaki, Tsumura, Miyuki, Yoshida, Kenichi, Ohnishi, Hidenori, Kato, Zenichiro, Yamazaki, Masahide, Okuno, Yusuke, Miyano, Satoru, Kojima, Seiji, Ogawa, Seishi, Andrews, T Daniel, Field, Matthew A, Burgio, Gaetan, Morio, Tomohiro, Vinuesa, Carola G, Kanegane, Hirokazu, Cook, Matthew C

“…Genetic mutations account for many devastating early onset immune deficiencies. In contrast, less severe and later onset immune diseases, including in patients…”
Get full text

IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model by Cardinez, Chelisa, Hao, Yuwei, Kwong, Kristy, Davies, Ainsley R., Downes, Morgan B., Roberts, Nadia A., Price, Jason D., Hernandez, Raquel A., Lovell, Jessica, Chand, Rochna, Feng, Zhi-Ping, Enders, Anselm, Vinuesa, Carola G., Miraghazadeh, Bahar, Cook, Matthew C.

“…Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3+ regulatory T cells (Tregs). By contrast, we know very…”
Get full text

Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease by Dorjbal, Batsukh, Stinson, Jeffrey R., Ma, Chi A., Weinreich, Michael A., Miraghazadeh, Bahar, Hartberger, Julia M., Frey-Jakobs, Stefanie, Weidinger, Stephan, Moebus, Lena, Franke, Andre, Schäffer, Alejandro A., Bulashevska, Alla, Fuchs, Sebastian, Ehl, Stephan, Limaye, Sandhya, Arkwright, Peter D., Briggs, Tracy A., Langley, Claire, Bethune, Claire, Whyte, Andrew F., Alachkar, Hana, Nejentsev, Sergey, DiMaggio, Thomas, Nelson, Celeste G., Stone, Kelly D., Nason, Martha, Brittain, Erica H., Oler, Andrew J., Veltri, Daniel P., Leahy, T. Ronan, Conlon, Niall, Poli, Maria C., Borzutzky, Arturo, Cohen, Jeffrey I., Davis, Joie, Lambert, Michele P., Romberg, Neil, Sullivan, Kathleen E., Paris, Kenneth, Freeman, Alexandra F., Lucas, Laura, Chandrakasan, Shanmuganathan, Savic, Sinisa, Hambleton, Sophie, Patel, Smita Y., Jordan, Michael B., Theos, Amy, Lebensburger, Jeffrey, Atkinson, T. Prescott, Torgerson, Troy R., Chinn, Ivan K., Milner, Joshua D., Grimbacher, Bodo, Cook, Matthew C., Snow, Andrew L.

“…Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold protein in lymphocytes that links antigen receptor engagement with downstream…”
Get full text

L-plastin associated syndrome of immune deficiency and hematologic cytopenia by Hernandez, Raquel A., Hearn, James I., Bhoopalan, Vijay, Hamzeh, Abdul Rezzak, Kwong, Kristy, Diamand, Koula, Davies, Ainsley, Li, Fei-Ju, Padmanabhan, Harish, Milne, Rachel, Ballard, Fiona, Spensberger, Dominik, Gardiner, Elizabeth E., Miraghazadeh, Bahar, Enders, Anselm, Cook, Matthew C.

“…LCP1 encodes L-plastin, an actin-bundling protein primarily expressed in hematopoietic cells. In mouse and fish models, LCP1 deficiency has been shown to…”
Get full text

L-plastin associated syndrome of immune deficiency and haematological cytopenia (PASIC) by Hernandez, Raquel A, Hearn, James I, Bhoopalan, Vijay, Hamzeh, Abdul R, Kwong, Kristy, Diamand, Koula, Davies, Ainsley, Li, Fei-Ju, Padmanabhan, Harish, Milne, Rachel, Ballard, Fiona, Spensberger, Dominik, Gardiner, Elizabeth E, Miraghazadeh, Bahar, Enders, Anselm, Cook, Matthew C

“…LCP1 encodes L-plastin, an actin-bundling protein primarily expressed in hematopoietic cells. In mouse and fish models, LCP1 deficiency has been shown to…”
Get full text

CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells by Hao, Yuwei, Miraghazadeh, Bahar, Chand, Rochna, Davies, Ainsley R., Cardinez, Chelisa, Kwong, Kristy, Downes, Morgan B., Sweet, Rebecca A., Cañete, Pablo F., D’Orsogna, Lloyd J., Fulcher, David A., Choo, Sharon, Yip, Desmond, Peters, Geoffrey, Yip, Sonia, Witney, Matthew J., Nekrasov, Maxim, Feng, Zhi-Ping, Tscharke, David C., Vinuesa, Carola G., Cook, Matthew C.

“…As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis of affected patients could yield…”
Get full text

Hypomorphic CARD11 mutations associated with diverse immunologic phenotypes with or without atopic disease by Dorjbal, Batsukh, Stinson, Jeffrey R., Ma, Chi A., Weinreich, Michael A., Miraghazadeh, Bahar, Hartberger, Julia M., Frey-Jakobs, Stefanie, Weidinger, Stephan, Moebus, Lena, Franke, Andre, Schäffer, Alejandro A., Bulashevska, Alla, Fuchs, Sebastian, Ehl, Stephan, Limaye, Sandhya, Arkwright, Peter D., Briggs, Tracy A., Langley, Claire, Bethune, Claire, Whyte, Andrew F., Alachkar, Hana, Nejentsev, Sergey, DiMaggio, Thomas, Nelson, Celeste G., Stone, Kelly D., Nason, Martha, Brittain, Erica H., Oler, Andrew J., Veltri, Daniel P., Leahy, T. Ronan, Conlon, Niall, Poli, Maria C., Borzutzky, Arturo, Cohen, Jeffrey I., Davis, Joie, Lambert, Michele P., Romberg, Neil, Sullivan, Kathleen E., Paris, Kenneth, Freeman, Alexandra F., Lucas, Laura, Chandrakasan, Shanmuganathan, Savic, Sinisa, Hambleton, Sophie, Patel, Smita Y, Jordan, Michael B., Theos, Amy, Lebensburger, Jeffrey, Atkinson, T. Prescott, Torgerson, Troy R., Chinn, Ivan K., Milner, Joshua D., Grimbacher, Bodo, Cook, Matthew C., Snow, Andrew L.

“…This description of a large cohort of patients broadens the spectrum of clinical disease phenotypes linked to CARD11 DN mutations, including atopy, cutaneous…”
Get full text