Etablierung Eines Neuen Biomarkers zur Prognosevorhersage des Kolorektalen Karzinoms
ObjectivesThe aim of this work was to analyze different biomarkers regarding their prognostic potential for colorectal carcinoma. In addition, a new biomarker (NCR) was developed. It was hypothesized that the combination of different biomarkers would allow an improved prognosis as well as a more ind...
Saved in:
| Main Author: | |
|---|---|
| Format: | Dissertation |
| Language: | German |
| Published: |
ProQuest Dissertations & Theses
01-01-2022
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | ObjectivesThe aim of this work was to analyze different biomarkers regarding their prognostic potential for colorectal carcinoma. In addition, a new biomarker (NCR) was developed. It was hypothesized that the combination of different biomarkers would allow an improved prognosis as well as a more individualized therapy.The focus was the investigation of NCR, which represents the relationship between inflammation associated blood parameters (albumin, CRP) and nutritional status (BMI). The overall aim of the present work was to establish the NCR long-term as a parameter in tumor diagnostics. In addition, the relevance of the NLR for prognosis of CRC was considered in more detail.Design & MethodsThe study cohort included 159 patients of the Erlangen Colorectal Cancer Registry from 2005-2013. Blood was drawn from the patients preoperatively and various inflammation-associated parameters were measured (LCR, NLR, PLR, ALI). Patient data were subdivided according to clinicopathological characteristics, based on which the measured inflammatory parameters could be evaluated via ROC curve analysis.Observations & ResultsIt was shown that the NCR value had a higher prognostic value than previously accepted markers. This observation was also confirmed for prognosis with respect to tumor location, in the right or left sided colon. Further, NCR could be considered for indication of adjuvant chemotherapy.ConclusionsBecause of its low-cost and largely risk-free sampling, future investigations to further confirm the prognostic adequacy can be performed easily and with little effort. Thus, NCR brings the potential to find wide application as a costeffective and reliable biomarker and to further improve the prognosis of CRC patients. |
|---|---|
| ISBN: | 9798383065242 |