Search Results - "Miracle Nayagam, Sharon"

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc by Rajasekaran, Shanmuganathan, Soundararajan, Dilip Chand Raja, Tangavel, Chitraa, K S, Sri Vijay Anand, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Muthurajan, Raveendran, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, Dharmalingam, K

“…Profiling proteins expressed in the nucleus pulposus of fetal intervertebral disc (IVD). To evaluate the molecular complexity of fetal IVDs not exposed to…”
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Subclinical infection can be an initiator of inflammaging leading to degenerative disk disease: evidence from host-defense response mechanisms by Rajasekaran, S., Chitraa, Tangavel, Dilip Chand Raja, S., Raveendran, M., Sharon Miracle, Nayagam, Sri Vijayanand, K. S., Ajoy Prasad, Shetty, Rishi Mugesh, Kanna

“…Purpose There is considerable controversy on the role of genetics, mechanical and environmental factors, and, recently, on subclinical infection in triggering…”
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Profiling extra cellular matrix associated proteome of human fetal nucleus pulposus in search for regenerative targets by Rajasekaran, Shanmuganathan, Thangavel, Chitra, Djuric, Niek, Raveendran, Muthurajan, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Sri Vijay Anand, K. S., Venkateshwaran, Krishna

“…Degeneration of the intervertebral disc is associated with a decrease in extra-cellular matrix (ECM) content due to an imbalance in anabolic and catabolic…”
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Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs by Rajasekaran, Shanmuganathan, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Tangavel, Chitraa, Raveendran, Muthuraja, K S, Sri Vijay Anand, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh

“…Profiling proteins expressed in the nucleus pulposus (NP) of intervertebral discs (IVDs) in five different biological states. To evaluate the molecular…”
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Comparative metagenomic analysis of human intervertebral disc nucleus pulposus and cartilaginous end plates by Shanmuganathan, Rajasekaran, Tangavel, Chitraa, K S, Sri Vijay Anand, Muthurajan, Raveendran, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Rajendran, Sunmathi, Kanna, Rishi Mugesh, Shetty, Ajoy Prasad

“…Study designThe diversity of microflora inhabiting endplate (EP) and nucleus pulposus (NP) tissues of human intervertebral disc (IVD) was profiled through…”
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Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma by Rajasekaran, Shanmuganathan, Tangavel, Chitraa, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Muthurajan, Raveendran, Anand, K.S. Sri Vijay, Rajendran, Sunmathi, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, Kuppamuthu, Dharmalingam

“…Objective To catalog and characterize the proteome of normal human intervertebral disc (IVD). Methods Nine magnetic resonance imaging (MRI) normal IVDs were…”
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Does the gut microbiome influence disc health and disease? The interplay between dysbiosis, pathobionts, and disc inflammation: a pilot study by Rajasekaran, Shanmuganathan, Vasudevan, Gowdaman, Tangavel, Chitraa, Ramachandran, Karthik, Nayagam, Sharon Miracle, Muthurajan, Raveendran, Gopalakrishnan, Chellappa, Anand, Sri Vijay, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh

“…Gut microbiome alterations resulting in inflammatory responses have been implicated in many distant effects on different organs. However, its influence on disc…”
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Human intervertebral discs harbour a unique microbiome and dysbiosis determines health and disease by Rajasekaran, Shanmuganathan, Soundararajan, Dilip Chand Raja, Tangavel, Chitraa, Muthurajan, Raveendran, Sri Vijay Anand, K. S., Matchado, Monica Steffi, Nayagam, Sharon Miracle, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, Dharmalingam, K.

“…Background To document the role of sub-clinical infections in disc disorders and investigate the existence of microbiome in intervertebral discs (IVD). Methods…”
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Elucidating the immunomodulatory role of endocannabinoids in intervertebral disc degeneration by Vasudevan, Gowdaman, Ramachandran, Karthik, Tangavel, Chitraa, Nayagam, Sharon Miracle, Gopalakrishnan, Chellappa, Muthurajan, Raveendran, Sri Vijay Anand, K. S., Rajasekaran, Shanmuganathan

“…The endocannabinoid system (ECS) has been well-established to play a crucial role in the regulation of several physiological processes as well as many…”
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Bacteria in human lumbar discs – subclinical infection or contamination? Metabolomic evidence for colonization, multiplication, and cell-cell cross-talk of bacteria by Rajasekaran, Shanmuganathan, Tangavel, Chitraa, Vasudevan, Gowdaman, Easwaran, Murugesh, Muthurajan, Raveendran, K S, Sri Vijay Anand, Murugan, Chandhan, Nayagam, Sharon Miracle, Kanna, Rishi Mugesh, Shetty, Ajoy Prasad

“…The accumulating evidence associating sub-clinical infection with disc degeneration (DD) and the controversy of contamination versus infection mandates a…”
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Modic changes are associated with activation of intense inflammatory and host defense response pathways – molecular insights from proteomic analysis of human intervertebral discs by Rajasekaran, S, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Tangavel, Chitraa, Raveendran, M, Thippeswamy, Pushpa Bhari, Djuric, Niek, Anand, Sri Vijay, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh

“…Patients with modic changes (MC) form a distinct clinical subset with reports of higher intensity of pain, poor clinical and surgical outcomes and higher…”
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ISSLS PRIZE IN CLINICAL SCIENCE 2017: Is infection the possible initiator of disc disease? An insight from proteomic analysis by Rajasekaran, S., Tangavel, Chitraa, Aiyer, Siddharth N., Nayagam, Sharon Miracle, Raveendran, M., Demonte, Naveen Luke, Subbaiah, Pramela, Kanna, Rishi, Shetty, Ajoy Prasad, Dharmalingam, K.

“…Study design Proteomic and 16S rDNA analysis of disc tissues obtained in vivo. Objective To address the controversy of infection as an aetiology for disc…”
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Identification of extracellular matrix proteins in plasma as a potential biomarker for intervertebral disc degeneration by Nayagam, Sharon Miracle, Ramachandran, Karthik, Selvaraj, Ganesh, Sunmathi, R., Easwaran, Murugesh, Palraj, Narmatha Devi, Anand K. S., Sri Vijay, Muthurajan, Raveendran, Tangavel, Chitraa, Rajasekaran, S.

“…Purpose Recently, there has been significant focus on extracellular matrix proteolysis due to its importance in the pathological progression of intervertebral…”
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Inflammaging determines health and disease in lumbar discs—evidence from differing proteomic signatures of healthy, aging, and degenerating discs by Rajasekaran, S., Tangavel, Chitraa, K.S., Sri Vijay Anand, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Raveendran, M, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, Dharmalingam, K.

“…The true understanding of aging and disc degeneration (DD) is still elusive. MRI has not helped our attempts to understand the health and disease status of the…”
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Part 1: profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets by Rajasekaran, Shanmuganathan, Tangavel, Chitraa, Djuric, Niek, Raveendran, Muthurajan, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Anand, K. S. Sri Vijay

“…Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) due to an imbalance in anabolic and catabolic pathways. Identifying…”
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Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small leucine-rich proteoglycans hold the key? by Rajasekaran, Shanmuganathan, Soundararajan, Dilip Chand Raja, Tangavel, Chitraa, Nayagam, Sharon Miracle, K S, Sri Vijayanand, R, Sunmathi, Matchado, Monica Steffi, Muthurajan, Raveendran, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, K, Dharmalingam

“…Small leucine-rich proteoglycans (SLRPs) play an essential role in extracellular matrix (ECM) organization and function. Recently, dysregulation of SLRPs has…”
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Influence of endplate avulsion and Modic changes on the inflammation profile of herniated discs: a proteomic and bioinformatic approach by Djuric, Niek, Rajasekaran, Shanmuganathan, Tangavel, Chitra, Raveendran, Muthurajan, Soundararajan, Dilip Chand Raja, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Anand, K. S. Sri Vijay, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh

“…Purpose The aim of this observational radiographic and proteomic study is to explore the influence of both Modic change (MC) and endplate avulsion (EPA) on the…”
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Modic changes are associated with activation of intense inflammatory and host defense response pathways -- molecular insights from proteomic analysis of human intervertebral discs by Rajasekaran, S., Chand Raja, Dilip, Miracle Nayagam, Sharon, Tangavel, Chitraa, Raveendran, M., Bhari Thippeswamy, Pushpa, Djuric, Niek, Sri Vijay Anand, KS, Mugesh Kanna, Rishi, Prasad, Shetty Ajoy

“…Patients with Modic changes form a distinct clinical subset with reports of higher intensity of pain, poor clinical and surgical outcomes and higher incidence…”
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Inflammaging determines health and disease in lumbar discs: evidence from differing proteomic signatures of healthy, aging and degenerating discs by Rajasekaran, S., Tangavel, Chitraa, Anand, Sri Vijay, Raja, Dilip Chand, Nayagam, Sharon Miracle, Matchado, Monica Steffi, Raveendran, M., Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, Dharmalingam, K.

“…The true understanding of aging and disc degeneration (DD) is still elusive. MRI has not helped our attempts to understand the health and disease status of the…”
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The Spine Journal Outstanding Paper Awards Presentations Outstanding Paper: Basic Science Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small leucine-rich proteoglycans hold the key? by Rajasekaran, S., Raja, Dilip Chand, Tangavel, Chitraa, Nayagam, Sharon Miracle, Sri Vijay Anand, K S, Sunmathi, R., Matchado, Monica Steffi, Raveendran, M., Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, Dharmalingam, K.

“…Small leucine-rich proteoglycans (SLRPs) play an essential role in extracellular matrix (ECM) organization and function. Recently, dysregulation of SLRPs has…”
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