Search Results - "Mirabella, Fabio"

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target by Fok, Jacqueline H L, Hedayat, Somaieh, Zhang, Lei, Aronson, Lauren I, Mirabella, Fabio, Pawlyn, Charlotte, Bright, Michael D, Wardell, Christopher P, Keats, Jonathan J, De Billy, Emmanuel, Rye, Carl S, Chessum, Nicola E A, Jones, Keith, Morgan, Gareth J, Eccles, Suzanne A, Workman, Paul, Davies, Faith E

“…Myeloma is a plasma cell malignancy characterized by the overproduction of immunoglobulin, and is therefore susceptible to therapies targeting protein…”
Get full text

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma by Kaiser, Martin F., Johnson, David C., Wu, Ping, Walker, Brian A., Brioli, Annamaria, Mirabella, Fabio, Wardell, Christopher P., Melchor, Lorenzo, Davies, Faith E., Morgan, Gareth J.

“…Outcome in multiple myeloma is highly variable and a better understanding of the factors that influence disease biology is essential to understand and predict…”
Get full text

Use of Leaf and Fruit Morphometric Analysis to Identify and Classify White Mulberry (Morus alba L.) Genotypes by Lo Bianco, Riccardo, Mirabella, Fabio

“…Digital image analysis and multivariate data analysis were used in this study to identify a set of leaf and fruit morphometric traits to discriminate white…”
Get full text

Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression by Li, Ni, Johnson, David C., Weinhold, Niels, Studd, James B., Orlando, Giulia, Mirabella, Fabio, Mitchell, Jonathan S., Meissner, Tobias, Kaiser, Martin, Goldschmidt, Hartmut, Hemminki, Kari, Morgan, Gareth J., Houlston, Richard S.

“…Genome-wide association studies have identified several risk loci for multiple myeloma (MM); however, the mechanisms by which they influence MM are unknown…”
Get full text

Improved risk stratification in myeloma using a microRNA‐based classifier by Wu, Ping, Agnelli, Luca, Walker, Brian A., Todoerti, Katia, Lionetti, Marta, Johnson, David C., Kaiser, Martin, Mirabella, Fabio, Wardell, Christopher, Gregory, Walter M., Davies, Faith E., Brewer, Daniel, Neri, Antonino, Morgan, Gareth J.

“…Summary Multiple myeloma (MM) is a heterogeneous disease. International Staging System/fluorescence hybridization (ISS/FISH)‐based model and gene expression…”
Get full text

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress by Zhang, Lei, Fok, Jacqueline J.L, Mirabella, Fabio, Aronson, Lauren I, Fryer, Rosemary A, Workman, Paul, Morgan, Gareth J, Davies, Faith E

“…Abstract Multiple myeloma (MM) cells rely on protein homeostatic mechanisms for survival. These mechanisms could be therapeutically targeted via modulation of…”
Get full text

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex by Mirabella, Fabio, Murison, Alexander, Aronson, Lauren I, Wardell, Christopher P, Thompson, Andrew J, Hanrahan, Sarah J, Fok, Jacqueline H L, Pawlyn, Charlotte, Kaiser, Martin F, Walker, Brian A, Davies, Faith E, Morgan, Gareth J

“…The chromosomal translocation t(4;14) deregulates MMSET (WHSC1/NSD2) expression and is a poor prognostic factor in multiple myeloma (MM). MMSET encodes two…”
Get full text

A Conserved Insulator That Recruits CTCF and Cohesin Exists between the Closely Related but Divergently Regulated Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor Genes by Bowers, Sarion R., Mirabella, Fabio, Calero-Nieto, Fernando J., Valeaux, Stephanie, Hadjur, Suzana, Baxter, Euan W., Merkenschlager, Matthias, Cockerill, Peter N.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma by Walker, Brian A, Boyle, Eileen M, Wardell, Christopher P, Murison, Alex, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Johnson, David C, Kaiser, Martin F, Melchor, Lorenzo, Aronson, Lauren I, Scales, Matthew, Pawlyn, Charlotte, Mirabella, Fabio, Jones, John R, Brioli, Annamaria, Mikulasova, Aneta, Cairns, David A, Gregory, Walter M, Quartilho, Ana, Drayson, Mark T, Russell, Nigel, Cook, Gordon, Jackson, Graham H, Leleu, Xavier, Davies, Faith E, Morgan, Gareth J

“…At the molecular level, myeloma is characterized by copy number abnormalities and recurrent translocations into the immunoglobulin heavy chain locus. Novel…”
Get full text

Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms by Walker, B A, Wardell, C P, Melchor, L, Brioli, A, Johnson, D C, Kaiser, M F, Mirabella, F, Lopez-Corral, L, Humphray, S, Murray, L, Ross, M, Bentley, D, Gutiérrez, N C, Garcia-Sanz, R, San Miguel, J, Davies, F E, Gonzalez, D, Morgan, G J

“…The mechanisms involved in the progression from monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) to malignant multiple…”
Get full text

Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns by Moore, A S, Faisal, A, de Castro, D Gonzalez, Bavetsias, V, Sun, C, Atrash, B, Valenti, M, de Haven Brandon, A, Avery, S, Mair, D, Mirabella, F, Swansbury, J, Pearson, A D J, Workman, P, Blagg, J, Raynaud, F I, Eccles, S A, Linardopoulos, S

“…Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3 -ITD + acute myeloid leukaemia (AML). The paucity of…”
Get full text

The Novel Protein HSF1 Stress Pathway Inhibitor Bisamide CCT361814 Demonstrates Pre-Clinical Anti-Tumor Activity in Myeloma by Menezes, Karen, Aram, Grace, Mirabella, Fabio, Johnson, David C, Sherborne, Amy L, Houlston, Richard S, Cheeseman, Matthew D, Pasqua, Elisa, Clarke, Paul, Workman, Paul, Jones, Keith, Kaiser, Martin F

“…Introduction Multiple myeloma (MM) is a plasma cell malignancy, characterized by the constant production of immunoglobulins (Ig), making the tumor cells…”
Get full text

Abstract 3379: HSF1: Essential for myeloma cell survival and a promising therapeutic target by Fok, Jacqueline H L, Hedayat, Somaieh, Zhang, Lei, Aronson, Lauren I., Mirabella, Fabio, Eccles, Suzanne A., Davies, Faith E.

“…Abstract Heat shock factor 1 (HSF1), a transcription factor known as the “master regulator” of the heat shock response (HSR), is emerging as an exciting…”
Get full text

Inhibition of the Epigenetic Modifier EZH2 Upregulates Cell Cycle Control Genes to Inhibit Myeloma Cell Growth and Overcome High-Risk Disease Features by Pawlyn, Charlotte, Bright, Michael, Buros, Amy, Stein, Caleb K., Walters, Zoe, Aronson, Lauren, Mirabella, Fabio, Kaiser, Martin F, Jones, John R, Walker, Brian A, Jackson, Graham H, Clarke, Paul, Bergsagel, Leif, Workman, Paul, Chesi, Marta, Morgan, Gareth J, Davies, Faith E

“…Introduction High expression of the H3K27 histone methyltransferase EZH2 mRNA in myeloma (MM) patient samples is associated with molecular features of high…”
Get full text

Identifying Ultra-High Risk Myeloma By Integrated Molecular Genetic and Gene Expression Profiling by Sherborne, Amy L, Begum, Dil B, Price, Amy, Johnson, David C, Ellis, Sidra, Smith, Charlotte, Mirabella, Fabio, Menezes, Karen, Kimber, Scott, Jones, John R, Pawlyn, Charlotte, Houlston, Richard S, Russell, Nigel H., Jenner, Matthew W, Cook, Gordon, Striha, Alina, Collett, Corinne, Waterhouse, Anna, Gregory, Walter M, Cairns, David A, Drayson, Mark T, Owen, Roger G, Davies, Faith E, Morgan, Gareth J, Jackson, Graham H, Kaiser, Martin F

“…Introduction A significant proportion of myeloma patients relapse early and show short survival with current therapies. Molecular diagnostic tools are needed…”
Get full text

DNA Methylation Profiling of Myeloma Trial Patients Reveals Specific Epigenetic Changes Associated with Outcome by Johnson, David C, Begum, Dil B, Ellis, Sidra, Sherborne, Amy L, Price, Amy, Smith, Charlotte, Mirabella, Fabio, Menezes, Karen, Kimber, Scott, Jones, John R, Pawlyn, Charlotte, Jenner, Matthew W, Houlston, Richard S, Cook, Gordon, Russell, Nigel H., Striha, Alina, Collett, Corinne, Waterhouse, Anna, Gregory, Walter M, Cairns, David A, Drayson, Mark T, Owen, Roger G, Davies, Faith E, Morgan, Gareth J, Jackson, Graham H, Kaiser, Martin F

“…Introduction Epigenetic dysregulation is a hallmark of cancer and has significant impact on disease biology. The epigenetic structure of myeloma is…”
Get full text

The Human IL-3/Granulocyte-Macrophage Colony-Stimulating Factor Locus Is Epigenetically Silent in Immature Thymocytes and Is Progressively Activated during T Cell Development by Mirabella, Fabio, Baxter, Euan W, Boissinot, Marjorie, James, Sally R, Cockerill, Peter N

“…The closely linked IL-3 and GM-CSF genes are located within a cluster of cytokine genes co-expressed in activated T cells. Their activation in response to TCR…”
Get full text

High-Resolution, Genome Wide Analysis of DNA Methylation Provides Insights Into the Epigenetic Architecture of t(4;14) Myeloma by Kaiser, Martin F, Walker, Brian A, Wardell, Christopher P, Mirabella, Fabio, Fryer, Rosemary A, Johnson, David C, Fenwick, Kerry, Kozarewa, Iwanka, Davies, Faith E., Morgan, Gareth J.

“…Abstract 2385 The t(4;14) group in multiple myeloma (MM) is associated with a significantly impaired prognosis based on the overexpression of MMSET, a histone…”
Get full text

Discovery Of Genome Wide Epigenetic Programming In t(4;14) Multiple Myeloma and In The Progression From Myeloma To Plasma Cell Leukemia Via Methyl Binding Domain Protein Capture and Sequencing by Kaiser, Martin F, Murison, Alexander, Wardell, Christopher P, Johnson, David C, Pawlyn, Charlotte, Mirabella, Fabio, Melchor, Lorenzo, Fenwick, Kerry, Kozarewa, Iwanka, Davies, Faith E, Walker, Brian A, Morgan, Gareth J

“…The t(4;14) translocation in multiple myeloma is associated with aggressive disease behavior and shorter survival despite recent advances in therapy. The…”
Get full text

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients by Boyle, Eileen M, Walker, Brian A, Wardell, Christopher P, Murison, Alexander, Melchor, Lorenzo, Kaiser, Martin F, Begum, Dil, Proszek, Paula, Dahir, Nasrin, Johnson, David C, Pawlyn, Charlotte, Jones, John, Mirabella, Fabio, Brioli, Annamaria, Mikulasova, Aneta, Cairns, David A, Gregory, Walter, Quartilho, Ana, Drayson, Mark T, Russell, Nigel, Cook, Gordon, Jackson, Graham H, Davies, Faith E, Morgan, Gareth J.

“…▪ Background: The main genetic features of myeloma identified so far have been the presence of balanced translocations at the immunoglobulin heavy chain (IGH)…”
Get full text