A Comparison Of The Inhibitory Activity Of Selective PDE4 Inhibitors On Eosinophil Recruitment In Guinea Pig Skin

The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in...

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Bibliographic Details
Published in:	Memórias do Instituto Oswaldo Cruz Vol. 92; no. suppl. 2; pp. 193 - 196
Main Authors:	Teixeira, Mauro M, Miotla, J.M, Cooper, N, Gristwood, R.W, Hellewell, P.G
Format:	Journal Article
Language:	English
Published:	Brazil Fundação Oswaldo Cruz, Fiocruz 1997
Subjects:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Animals Cyclic Nucleotide Phosphodiesterases, Type 4 Eosinophils - drug effects eosinophils - phosphodiesterase inhibitors - rolipram - allergic inflammation Guinea Pigs Hypersensitivity - immunology Phosphodiesterase Inhibitors - pharmacology Pyrrolidinones - pharmacology Rolipram Skin - immunology
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Summary:	The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1678-8060 0074-0276
DOI:	10.1590/s0074-02761997000800025