Search Results - "Miot, Françoise"

NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation by Ameziane-El-Hassani, Rabii, Talbot, Monique, de Souza Dos Santos, Maria Carolina, Al Ghuzlan, Abir, Hartl, Dana, Bidart, Jean-Michel, De Deken, Xavier, Miot, Françoise, Diallo, Ibrahima, de Vathaire, Florent, Schlumberger, Martin, Dupuy, Corinne

“…Ionizing radiation (IR) causes not only acute tissue damage, but also late effects in several cell generations after the initial exposure. The thyroid gland is…”
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Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ by Driessens, Natacha, Versteyhe, Soetkin, Ghaddhab, Chiraz, Burniat, Agnès, De Deken, Xavier, Van Sande, Jacqueline, Dumont, Jacques-Emile, Miot, Françoise, Corvilain, Bernard

“…DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer but their induction by hydrogen peroxide (H2O2) is still controversial…”
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Functional model of rat thyroid follicles cultured in Matrigel by Khoruzhenko, Antonina, Miot, Françoise, Massart, Claude, Van Sande, Jacqueline, Dumont, Jacques Emile, Beauwens, Renaud, Boom, Alain

“…Background Long-term maintenance of functional activity of thyroid cells is an essential requirement for basic in vitro studies on the physiology and pathology…”
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Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes by Hadad, Ielham, Veithen, Alex, Springael, Jean-Yves, Sotiropoulou, Panagiota A, Mendes Da Costa, Agnès, Miot, Françoise, Naeije, Robert, De Deken, Xavier, Entee, Kathleen Mc

“…Stroma cell-derived factor-1α (SDF-1α) is a cardioprotective chemokine, acting through its G-protein coupled receptor CXCR4. In experimental acute myocardial…”
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Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family by De Deken, Xavier, Wang, Dantong, Many, Marie-Christine, Costagliola, Sabine, Libert, Frédérick, Vassart, Gilbert, Dumont, Jacques E., Miot, Françoise

“…Two cDNAs encoding NADPH oxidases and constituting the thyroid H2O2 generating system have been cloned. The strategy of cloning was based on the functional…”
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DUOX Defects and Their Roles in Congenital Hypothyroidism by De Deken, Xavier, Miot, Françoise

“…Extracellular hydrogen peroxide is required for thyroperoxidase-mediated thyroid hormone synthesis in the follicular lumen of the thyroid gland. Among the…”
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Commentary: Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture by Kyrilli, Aglaia, Paternot, Sabine, Miot, Françoise, Corvilain, Bernard, Vassart, Gilbert, Roger, Pierre P, Dumont, Jacques E

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Characterization of ThOX Proteins as Components of the Thyroid H2O2-Generating System by De Deken, Xavier, Wang, Dantong, Dumont, Jacques E., Miot, Françoise

“…We have recently cloned two thyroid-specific cDNAs encoding new members of the NADPH oxidase family. ThOX1 and ThOX2 proteins are colocalized with…”
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Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling by De Deken, Xavier, Corvilain, Bernard, Dumont, Jacques Emile, Miot, Françoise

“…Among the NADPH oxidases, the dual oxidases, DUOX1 and DUOX2, constitute a distinct subfamily initially called thyroid oxidases, based on their high level of…”
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The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model by Poncelet, Louise, Dumont, Jacques-Emile, Miot, Françoise, De Deken, Xavier

“…Thyroid hormone synthesis requires H2O2, produced by two NADPH oxidases, Duox1 and Duox2. To be fully active at the apical pole of the thyrocytes, these…”
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Murine Thyroid IL-4 Expression Worsens Hypothyroidism on Iodine Restriction and Mitigates Graves Disease Development by Merakchi, Karima, Djerbib, Sami, Soleimani, Manoocher, Dumont, Jacques-Emile, Miot, Françoise, De Deken, Xavier

“…Cytokines are known to perturb thyroid function and the role of interleukin-4 (IL-4) in the pathogenesis of Graves disease (GD) remains controversial. In our…”
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Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation by Rigutto, Sabrina, Hoste, Candice, Grasberger, Helmut, Milenkovic, Milutin, Communi, David, Dumont, Jacques E, Corvilain, Bernard, Miot, Françoise, De Deken, Xavier

“…Dual oxidases were initially identified as NADPH oxidases producing H(2)O(2) necessary for thyroid hormone biosynthesis. The crucial role of Duox2 has been…”
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IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response by Fink, Karin, Martin, Lydie, Mukawera, Esperance, Chartier, Stéfany, De Deken, Xavier, Brochiero, Emmanuelle, Miot, Françoise, Grandvaux, Nathalie

“…Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and…”
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Activation of Dual Oxidases Duox1 and Duox2 by Rigutto, Sabrina, Hoste, Candice, Grasberger, Helmut, Milenkovic, Milutin, Communi, David, Dumont, Jacques E., Corvilain, Bernard, Miot, Françoise, De Deken, Xavier

“…Dual oxidases were initially identified as NADPH oxidases producing H2O2 necessary for thyroid hormone biosynthesis. The crucial role of Duox2 has been…”
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Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2 by Raad, Houssam, Eskalli, Zineb, Corvilain, Bernard, Miot, Françoise, De Deken, Xavier

“…The dual oxidases (DUOX) 1 and 2 constitute the major components of the thyroid H(2)O(2)-generating system required for thyroid hormone synthesis. With their…”
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Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H₂O₂-generating enzyme DUOX2 associated with transient congenital hypothyroidism by Hoste, Candice, Rigutto, Sabrina, Van Vliet, Guy, Miot, Françoise, De Deken, Xavier

“…Dual oxidases (DUOX) 1 and 2 are components of the thyroid H₂O₂-generating system. H₂O₂ is used by thyroperoxidase to oxidize iodide for thyroid…”
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Factors contributing to the resistance of the thyrocyte to hydrogen peroxide by Ghaddhab, Chiraz, Kyrilli, Aglaia, Driessens, Natacha, Van Den Eeckhaute, Emmanuel, Hancisse, Olivier, De Deken, Xavier, Dumont, Jacques-Emile, Detours, Vincent, Miot, Françoise, Corvilain, Bernard

“…We studied the mechanism that may explain the relative resistance of thyrocytes to H2O2 compared to other cell types. Ability to degrade H2O2, glutathione…”
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The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA by Hoste, Candice, Dumont, Jacques Emile, Miot, Françoise, De Deken, Xavier

“…A deliberate generation of ROS is now recognized to be achieved by specific NADPH oxidases (NOX). Dual oxidases (DUOXs) are Ca2+-activated NOXs and operate as…”
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The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling by Kwon, Jaeyul, Shatynski, Kristen E, Chen, Haiyan, Morand, Stanislas, de Deken, Xavier, Miot, Françoise, Leto, Thomas L, Williams, Mark S

“…Production of reactive oxygen species, often by NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidases, plays a role in the signaling…”
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Expression, Localization, and Regulation of the Sodium Bicarbonate Cotransporter NBCe1 in the Thyroid by Virreira, Myrna, Jin, Ling, Djerbib, Sami, De Deken, Xavier, Miot, Françoise, Massart, Claude, Svoboda, Michal, Van Sande, Jacqueline, Beauwens, Renaud, Dumont, Jacques-Emile, Boom, Alain

“…The intrafollicular space of thyroid follicles is the storage compartment for thyroid hormones. Its pH has been established at around 7.6 at least after…”
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