Search Results - "Minze, Laurie J."

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation by Deng, Tuo, Lyon, Christopher J., Minze, Laurie J., Lin, Jianxin, Zou, Jia, Liu, Joey Z., Ren, Yuelan, Yin, Zheng, Hamilton, Dale J., Reardon, Patrick R., Sherman, Vadim, Wang, Helen Y., Phillips, Kevin J., Webb, Paul, Wong, Stephen T.C., Wang, Rong-fu, Hsueh, Willa A.

“…Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. Here, we describe…”
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Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells by Xing, Junji, Zhang, Ao, Du, Yong, Fang, Mingli, Minze, Laurie J., Liu, Yong-Jun, Li, Xian Chang, Zhang, Zhiqiang

“…Innate immune cells are critical in protective immunity against viral infections, involved in sensing foreign viral nucleic acids. Here we report that the…”
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TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus by Xing, Junji, Zhang, Ao, Minze, Laurie J, Li, Xian Chang, Zhang, Zhiqiang

“…The innate immunity is critically important in protection against virus infections, and in the case of RNA viral infections, the signaling mechanisms that…”
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TRIM18 is a critical regulator of viral myocarditis and organ inflammation by Fang, Mingli, Zhang, Ao, Du, Yong, Lu, Wenting, Wang, Junying, Minze, Laurie J, Cox, Timothy C, Li, Xian Chang, Xing, Junji, Zhang, Zhiqiang

“…Background Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as myocarditis, pneumonia and…”
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OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression by Ding, Zonghui, Liu, Yue, Rubio, Valentina, He, Jinjie, Minze, Laurie J., Shi, Zheng-Zheng

“…OLA1, an Obg-family GTPase, has been implicated in eukaryotic initiation factor 2 (eIF2)-mediated translational control, but its physiological functions remain…”
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Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3 by Liu, Yianzhu, Minze, Laurie J., Mumma, Lindsay, Li, Xian C., Ghobrial, Rafik M, Kloc, Malgorzata

“…The macrophages have different subtypes with different functions in immune response and disease. It has been generally accepted that M1 macrophages are…”
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Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells by Chu, Xiufeng, Xiao, Xiang, Wang, Guangchuan, Uosef, Ahmed, Lou, Xiaohua, Arnold, Preston, Wang, Yixuan, Kong, Gangcheng, Wen, Mou, Minze, Laurie J., Li, Xian C.

“…Gasdermin D (GSDMD) is a critical mediator of pyroptosis, which consists of a N-terminal pore-forming domain and a C-terminal autoinhibitory domain. Its…”
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Osteocalcin Protects Against Nonalcoholic Steatohepatitis in a Mouse Model of Metabolic Syndrome by Gupte, Anisha A, Sabek, Omaima M, Fraga, Daniel, Minze, Laurie J, Nishimoto, Satoru K, Liu, Joey Z, Afshar, Solmaz, Gaber, Lillian, Lyon, Christopher J, Gaber, A. Osama, Hsueh, Willa A

“…Nonalcoholic fatty liver disease, particularly its more aggressive form, nonalcoholic steatohepatitis (NASH), is associated with hepatic insulin resistance…”
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Myeloid Deletion of Nuclear Factor Erythroid 2−Related Factor 2 Increases Atherosclerosis and Liver Injury by Collins, Alan R, Gupte, Anisha A, Ji, Ruirui, Ramirez, Maricela R, Minze, Laurie J, Liu, Joey Z, Arredondo, Magda, Ren, Yuelan, Deng, Tuo, Wang, Jun, Lyon, Christopher J, Hsueh, Willa A

“…OBJECTIVE—To determine the impact of hematopoietic deletion of nuclear factor− (erythroid-derived 2) like 2 factor (Nrf2) on the development of atherosclerosis…”
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Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts by Liu, Yianzhu, MS, Chen, Wenhao, MD, PhD, Wu, Chenglin, MS, Minze, Laurie J., BS, Kubiak, Jacek Z., PhD, Li, Xian C., MD, PhD, Kloc, Malgorzata, PhD, DSc, Ghobrial, Rafik M., MD, PhD

“…Background The cellular and molecular mechanisms of chronic rejection of transplanted organs remain obscure; however, macrophages are known to play a critical…”
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OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation by Chen, Huarong, Song, Renduo, Wang, Guohui, Ding, Zonghui, Yang, Chunying, Zhang, Jiawei, Zeng, Zihua, Rubio, Valentina, Wang, Luchang, Zu, Nancy, Weiskoff, Amanda M., Minze, Laurie J., Jeyabal, Prince V.S., Mansour, Oula C., Bai, Li, Merrick, William C., Zheng, Shu, Shi, Zheng-Zheng

“…Translation is a fundamental cellular process and its dysregulation can contribute to human diseases such as cancer. During translation initiation the…”
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Rosiglitazone attenuates age‐ and diet‐associated nonalcoholic steatohepatitis in male low‐density lipoprotein receptor knockout mice by Gupte, Anisha A., Liu, Joey Z., Ren, Yuelan, Minze, Laurie J., Wiles, Jessica R., Collins, Alan R., Lyon, Christopher J., Pratico, Domenico, Finegold, Milton J., Wong, Stephen T., Webb, Paul, Baxter, John D., Moore, David D., Hsueh, Willa A.

“…Nonalcoholic fatty liver disease (NAFLD) is a common complication of obesity that can progress to nonalcoholic steatohepatitis (NASH), a serious liver…”
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TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions by Lou, Xiaohua, Ma, Binbin, Zhuang, Yuan, Xiao, Xiang, Minze, Laurie J., Xing, Junji, Zhang, Zhiqiang, Li, Xian C.

“…Protein ubiquitination is a post-translation modification mediated by E3 ubiquitin ligases. The RING domain E3 ligases are the largest family of E3 ubiquitin…”
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Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex by Lou, Xiaohua, Ma, Binbin, Zhuang, Yuan, Xiao, Xiang, Minze, Laurie J., Xing, Junji, Zhang, Zhiqiang, Li, Xian C.

“…[Display omitted] Protein ubiquitination plays a vital role in controlling the degradation of intracellular proteins and in regulating cell signaling pathways…”
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DHX15 is required to control RNA virus-induced intestinal inflammation by Xing, Junji, Zhou, Xiaojing, Fang, Mingli, Zhang, Evan, Minze, Laurie J., Zhang, Zhiqiang

“…RNA helicases play critical roles in various biological processes, including serving as viral RNA sensors in innate immunity. Here, we find that RNA helicase…”
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Mechanisms involved in controlling RNA virus-induced intestinal inflammation by Zhang, Evan, Fang, Mingli, Jones, Colette, Minze, Laurie J., Xing, Junji, Zhang, Zhiqiang

“…Gastroenteritis is inflammation of the lining of stomach and intestines and causes significant morbidity and mortality worldwide. Many viruses, especially RNA…”
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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction by Wu, Jie, Zhang, Hedong, Shi, Xiaomin, Xiao, Xiang, Fan, Yihui, Minze, Laurie J., Wang, Jin, Ghobrial, Rafik M., Xia, Jiahong, Sciammas, Roger, Li, Xian C., Chen, Wenhao

“…CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains…”
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The clock gene, brain and muscle Arnt‐like 1, regulates adipogenesis via Wnt signaling pathway by Guo, Bingyan, Chatterjee, Somik, Li, Lifei, Kim, Ji M., Lee, Jeongkyung, Yechoor, Vijay K., Minze, Laurie J., Hsueh, Willa, Ma, Ke

“…ABSTRACT Circadian clocks in adipose tissue are known to regulate adipocyte biology. Although circadian dysregulation is associated with development of…”
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Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer by Zou, Dawei, Zhang, Xiaolong, Li, Shuang, Xiao, Xiang, Gonzalez, Nancy M., Minze, Laurie J., Li, Xian C., Chen, Wenhao

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CD4+ T cell immunity is dependent on an intrinsic stem-like program by Zou, Dawei, Yin, Zheng, Yi, Stephanie G., Wang, Guohua, Guo, Yang, Xiao, Xiang, Li, Shuang, Zhang, Xiaolong, Gonzalez, Nancy M., Minze, Laurie J., Wang, Lin, Wong, Stephen T. C., Osama Gaber, A., Ghobrial, Rafik M., Li, Xian C., Chen, Wenhao

“…CD4 + T cells are central to various immune responses, but the molecular programs that drive and maintain CD4 + T cell immunity are not entirely clear. Here we…”
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