Search Results - "Mintzer, Robert"

Augmented Whole-Body Scanning via Magnifying PET by Jiang, Jianyong, Samanta, Suranjana, Li, Ke, Siegel, Stefan B., Mintzer, Robert A., Cho, Sanghee, Conti, Maurizio, Schmand, Matthias, O'Sullivan, Joseph, Tai, Yuan-Chuan

“…A novel technique, called augmented whole-body scanning via magnifying PET (AWSM-PET), that improves the sensitivity and lesion detectability of a PET scanner…”
Get full text

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase by Morisaki, J Hiroshi, Smith, Peter A, Date, Shailesh V, Kajihara, Kimberly K, Truong, Chau Linda, Modrusan, Zora, Yan, Donghong, Kang, Jing, Xu, Min, Shah, Ishita M, Mintzer, Robert, Kofoed, Eric M, Cheung, Tommy K, Arnott, David, Koehler, Michael F T, Heise, Christopher E, Brown, Eric J, Tan, Man-Wah, Hazenbos, Wouter L W

“…The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly…”
Get full text

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C by Mintzer, Robert, Ramaswamy, Sreemathy, Shah, Kinjalkumar, Hannoush, Rami N, Pozniak, Christine D, Cohen, Frederick, Zhao, Xianrui, Plise, Emile, Lewcock, Joseph W, Heise, Christopher E

“…Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for…”
Get full text

Automated Least-Squares Calibration of the Coregistration Parameters for a Micro PET-CT System by Bing Feng, Shikui Yan, Mu Chen, Austin, D. W., Junjun Deng, Mintzer, R. A.

“…PET-CT coregistration parameters can be derived from PET and CT images of a four-point-source calibration phantom for a micro PET-CT scanner. An automated…”
Get full text

Tc-99m pyrophosphate imaging of poloxamer-treated electroporated skeletal muscle in an in vivo rat model by Matthews, Kenneth L., Aarsvold, John N., Mintzer, Robert A., Chen, Chin-Tu, Lee, Raphael C.

“…This study investigates whether 99mTc pyrophosphate (PYP) imaging provides a quantitative non-invasive assessment of the extent of electroporation injury, and…”
Get full text

A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase by Seto, Marian, Whitlow, Marc, McCarrick, Margaret A., Srinivasan, Subha, Zhu, Ying, Pagila, Rene, Mintzer, Robert, Light, David, Johns, Anthony, Meurer‐Ogden, Janet A.

“…Sequence profile and fold recognition methods identified mammalian purple acid phosphatase (PAP), a member of a dimetal‐containing phosphoesterase (DMP)…”
Get full text

Holistic evaluation of a machine learning-based timing calibration for PET detectors under varying data sparsity by Naunheim, Stephan, Mueller, Florian, Nadig, Vanessa, Kuhl, Yannick, Breuer, Johannes, Zhang, Nan, Cho, Sanghee, Kapusta, Maciej, Mintzer, Robert, Judenhofer, Martin, Schulz, Volkmar

“…Modern PET scanners offer precise TOF information, improving the SNR of the reconstructed images. Timing calibrations are performed to reduce the worsening…”
Get more information

Intraoperative gamma imaging of axillary sentinel lymph nodes in breast cancer patients by Aarsvod, John N., Greene, Carmen M., Mintzer, Robert A., Grant, Sandra F., Styblo, Toncred M., Alazraki, Naomi P., Patt, Bradley E., Caravaglia, Gina M., Li, Joshua, Iwanczyk, Jan S.

“…Sentinel lymph node (SLN) biopsy is now standard practice in the management of many breast cancer patients. Localization protocols vary in complexity and rates…”
Get full text

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability by Lauffer, Benjamin E.L., Mintzer, Robert, Fong, Rina, Mukund, Susmith, Tam, Christine, Zilberleyb, Inna, Flicke, Birgit, Ritscher, Allegra, Fedorowicz, Grazyna, Vallero, Roxanne, Ortwine, Daniel F., Gunzner, Janet, Modrusan, Zora, Neumann, Lars, Koth, Christopher M., Lupardus, Patrick J., Kaminker, Joshua S., Heise, Christopher E., Steiner, Pascal

“…Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation of their activity has been implicated in a broad range of…”
Get full text

A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase by Mintzer, Robert J, Appell, Kenneth C, Cole, Andrew, Johns, Anthony, Pagila, Rene, Polokoff, Mark A, Tabas, Ira, Snider, R Michael, Meurer-Ogden, Janet A

“…Secreted extracellular acid sphingomyelinase (sASM) activity has been suggested to promote atherosclerosis by enhancing subendothelial aggregation and…”
Get more information

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors by Staben, Steven T, Feng, Jianwen A, Lyle, Karen, Belvin, Marcia, Boggs, Jason, Burch, Jason D, Chua, Ching-ching, Cui, Haifeng, DiPasquale, Antonio G, Friedman, Lori S, Heise, Christopher, Koeppen, Hartmut, Kotey, Adrian, Mintzer, Robert, Oh, Angela, Roberts, David Allen, Rouge, Lionel, Rudolph, Joachim, Tam, Christine, Wang, Weiru, Xiao, Yisong, Young, Amy, Zhang, Yamin, Hoeflich, Klaus P

“…Structure-based methods were used to design a potent and highly selective group II p21-activated kinase (PAK) inhibitor with a novel binding mode, compound 17…”
Get full text

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors by Crawford, James J, Lee, Wendy, Aliagas, Ignacio, Mathieu, Simon, Hoeflich, Klaus P, Zhou, Wei, Wang, Weiru, Rouge, Lionel, Murray, Lesley, La, Hank, Liu, Ning, Fan, Peter W, Cheong, Jonathan, Heise, Christopher E, Ramaswamy, Sreemathy, Mintzer, Robert, Liu, Yanzhou, Chao, Qi, Rudolph, Joachim

“…The p21-activated kinases (PAKs) play important roles in cytoskeletal organization, cellular morphogenesis, and survival and have generated significant…”
Get full text

Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase by Marathe, Sudhir, Schissel, Scott L., Yellin, Michael J., Beatini, Nanda, Mintzer, Robert, Williams, Kevin Jon, Tabas, Ira

“…We recently reported that macrophages and fibroblasts secrete a Zn 2+ -dependent sphingomyelinase (S-SMase), which, like lysosomal SMase, is a product of the…”
Get full text

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors by Lee, Wendy, Crawford, James J., Aliagas, Ignacio, Murray, Lesley J., Tay, Suzanne, Wang, Weiru, Heise, Christopher E., Hoeflich, Klaus P., La, Hank, Mathieu, Simon, Mintzer, Robert, Ramaswamy, Sreemathy, Rouge, Lionel, Rudolph, Joachim

“…[Display omitted] A series of 4-azaindole-containing p21-activated kinase-1 (PAK1) inhibitors was prepared with the goal of improving physicochemical…”
Get full text

Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling by Marathe, S, Schissel, S L, Yellin, M J, Beatini, N, Mintzer, R, Williams, K J, Tabas, I

“…We recently reported that macrophages and fibroblasts secrete a Zn2+-dependent sphingomyelinase (S-SMase), which, like lysosomal SMase, is a product of the…”
Get full text

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates by Liu, Yichin, Beresini, Maureen H, Johnson, Adam, Mintzer, Robert, Shah, Kinjalkumar, Clark, Kevin, Schmidt, Stephen, Lewis, Cristina, Liimatta, Marya, Elliott, Linda O, Gustafson, Amy, Heise, Christopher E

“…Identifying chemical lead matter by high-throughput screening (HTS) has been a common practice in early stage drug discovery. Evolution of small-molecule…”
Get more information

Design and performance of a new pixelated- LSO/PSPMT gamma-ray detector for high resolution PET imaging by Mintzer, R.A., Siegel, S.B.

“…The gamma-ray detector developed for the Siemens Inveontrade small animal PET systems affords improved light collection and reduced number of photodetectors,…”
Get full text

Validation of CT-based attenuation correction for multi-pinhole PSF reconstruction for small-animal SPECT by Austin, D W, Bing Feng, Mintzer, R A, Mu Chen, Gregor, J, Stuckey, A C, Wall, J S

“…We recently reported a numerical ray-tracing algorithm for calculating the point-spread function (PSF) used in 3-D ordered subsets expectation maximization…”
Get full text

Automated least-squares calibration of the coregistration parameters for a micro PET-CT system by Bing Feng, Shikui Yan, Mu Chen, Austin, D W, Junjun Deng, Mintzer, R A

“…A previously developed method derives co-registration parameters from PET and CT images of a four-point-source calibration phantom by manually adjusting the…”
Get full text

Continuously sampled digital pulse processing for inveon small animal PET scanner by McFarland, A.R., Siegel, S., Newport, D.F., Mintzer, R., Atkins, B., Lenox, M.

“…The quicksilver event processing module (EPM) is a key component of a high performance data acquisition platform from Siemens Molecular Imaging (Knoxville, TN)…”
Get full text