Search Results - "Minoru Iwata"

Genome-wide association study identifies three novel loci for type 2 diabetes by Hara, Kazuo, Fujita, Hayato, Johnson, Todd A, Yamauchi, Toshimasa, Yasuda, Kazuki, Horikoshi, Momoko, Peng, Chen, Hu, Cheng, Ma, Ronald C W, Imamura, Minako, Iwata, Minoru, Tsunoda, Tatsuhiko, Morizono, Takashi, Shojima, Nobuhiro, So, Wing Yee, Leung, Ting Fan, Kwan, Patrick, Zhang, Rong, Wang, Jie, Yu, Weihui, Maegawa, Hiroshi, Hirose, Hiroshi, Kaku, Kohei, Ito, Chikako, Watada, Hirotaka, Tanaka, Yasushi, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Jia, Weiping, Chan, Juliana C N, Teo, Yik Ying, Shyong, Tai E, Kamatani, Naoyuki, Kubo, Michiaki, Maeda, Shiro, Kadowaki, Takashi

“…Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified…”
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FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men by Kamura, Yutaka, Iwata, Minoru, Maeda, Shiro, Shinmura, Satomi, Koshimizu, Yukiko, Honoki, Hisae, Fukuda, Kazuhito, Ishiki, Manabu, Usui, Isao, Fukushima, Yasuo, Takano, Atsuko, Kato, Hiromi, Murakami, Shihou, Higuchi, Kiyohiro, Kobashi, Chikaaki, Tobe, Kazuyuki

“…Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However,…”
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Clinical manifestations of a sporadic maturity-onset diabetes of the young (MODY) 5 with a whole deletion of HNF1B based on 17q12 microdeletion by Omura, Yoshiyuki, Yagi, Kunimasa, Honoki, Hisae, Iwata, Minoru, Enkaku, Asako, Takikawa, Akiko, Kuwano, Takahide, Watanabe, Yoshiyuki, Nishimura, Ayumi, Liu, Jianhui, Chujo, Daisuke, Fujisaka, Shiho, Enya, Mayumi, Horikawa, Yukio, Tobe, Kazuyuki

“…We report a sporadic case of maturity-onset diabetes of the young type 5 (MODY5) with a whole-gene deletion of the hepatocyte nuclear factor-1beta (HNF1B)…”
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Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population by Sakai, Kensuke, Imamura, Minako, Tanaka, Yasushi, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Maeda, Shiro

“…East Asian genome-wide association studies (GWAS) for type 2 diabetes identified 8 loci with genome-wide significance, and 2 loci with a borderline…”
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Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese by Ohshige, Toshihiko, Iwata, Minoru, Omori, Shintaro, Tanaka, Yasushi, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Kashiwagi, Atsunori, Kawamori, Ryuzo, Tobe, Kazuyuki, Kadowaki, Takashi, Nakamura, Yusuke, Maeda, Shiro

“…Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative…”
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Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance by Iwata, Minoru, Hara, Kazuo, Kamura, Yutaka, Honoki, Hisae, Fujisaka, Shiho, Ishiki, Manabu, Usui, Isao, Yagi, Kunimasa, Fukushima, Yasuo, Takano, Atsuko, Kato, Hiromi, Murakami, Shihou, Higuchi, Kiyohiro, Kobashi, Chikaaki, Fukuda, Kazuhito, Koshimizu, Yukiko, Tobe, Kazuyuki

“…Among the three adiponectin isoforms, a lower ratio of high molecular weight (HMW) adiponectin to total adiponectin (TA) is well known to cause insulin…”
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Assessing the Clinical Utility of a Genetic Risk Score Constructed Using 49 Susceptibility Alleles for Type 2 Diabetes in a Japanese Population by Imamura, Minako, Shigemizu, Daichi, Tsunoda, Tatsuhiko, Iwata, Minoru, Maegawa, Hiroshi, Watada, Hirotaka, Hirose, Hiroshi, Tanaka, Yasushi, Tobe, Kazuyuki, Kaku, Kohei, Kashiwagi, Atsunori, Kawamori, Ryuzo, Maeda, Shiro

“…Context: Genome-wide association studies (GWASs) have identified over 60 susceptibility loci for type 2 diabetes (T2D). Although the ability of previous…”
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Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients by Iwata, Minoru, Kamura, Yutaka, Honoki, Hisae, Kobayashi, Kaori, Ishiki, Manabu, Yagi, Kunimasa, Fukushima, Yasuo, Takano, Atsuko, Kato, Hiromi, Murakami, Shihou, Higuchi, Kiyohiro, Kobashi, Chikaaki, Fukuda, Kazuhito, Koshimizu, Yukiko, Tobe, Kazuyuki

“…Aims/Introduction The objective of the present study was to clarify the association of the type and number of first‐degree family history of diabetes (FHD)…”
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Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes by Matsuba, Ren, Sakai, Kensuke, Imamura, Minako, Tanaka, Yasushi, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Maeda, Shiro

“…We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified…”
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A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population by Fukuda, Hisashi, Imamura, Minako, Tanaka, Yasushi, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Maeda, Shiro

“…The DUSP9 locus on chromosome X was identified as a susceptibility locus for type 2 diabetes in a meta-analysis of European genome-wide association studies…”
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Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies by Matsuba, Ren, Imamura, Minako, Tanaka, Yasushi, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Maeda, Shiro

“…We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and six susceptibility loci (TMEM154, SSR1, FAF1,…”
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Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits by Fujita, Hayato, Hara, Kazuo, Shojima, Nobuhiro, Horikoshi, Momoko, Iwata, Minoru, Hirota, Yushi, Tobe, Kazuyuki, Seino, Susumu, Kadowaki, Takashi

“…The aim of the present study was to explore the role of variations with modest effects (previously identified by a large-scale meta-analysis in European…”
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Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway by Kobashi, Chikaaki, Asamizu, Sachie, Ishiki, Manabu, Iwata, Minoru, Usui, Isao, Yamazaki, Katusuya, Tobe, Kazuyuki, Kobayashi, Masashi, Urakaze, Masaharu

“…Various cytokines and other compounds are produced in human adipose tissue and might have functions in the adipose tissue. They might be involved in…”
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Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function by Asada, Tomohiko, Iwata, Minoru, Matsuzaki, Shigeru, Hamakawa, Hiroshi, Sengan, Satoru, Noguchi, Toshifumi, Daimon, Kazushi, Matsumura, Naoki, Shibasaki, Morikazu, Tsujimoto, Tetsushi, Ooi, Ken, Fukuyama, Hidenao

“…We present the case of a 55-year-old female patient with alcohol-related liver damage who presented with hypercalcemia and hyperphosphatemia but also showed…”
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Association of serum adiponectin with asthma and pulmonary function in the Japanese population by Hayashikawa, Yasuko, Iwata, Minoru, Inomata, Minehiko, Kawagishi, Yukio, Tokui, Kotaro, Taka, Chihiro, Kambara, Kenta, Okazawa, Seisuke, Yamada, Toru, Hayashi, Ryuji, Kamura, Yutaka, Okazawa, Teruyo, Matsui, Shoko, Kigawa, Mika, Tobe, Kazuyuki

“…Conflicting findings have been reported regarding the role of adiponectin in asthma. The aim of this study was to evaluate the association of adiponectin with…”
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Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin by Takano, Atsuko, Usui, Isao, Haruta, Tetsuro, Kawahara, Junko, Uno, Tatsuhito, Iwata, Minoru, Kobayashi, Masashi

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effects of Ultraviolet Irradiation and Atomic Oxygen Erosion on Total Electron Emission Yield of Polyimide by Jiang Wu, Miyahara, Akira, Khan, Arifur R., Iwata, Minoru, Toyoda, Kazuhiro, Mengu Cho, Xiao Quan Zheng

“…Polymers used on low earth orbit (LEO) spacecraft surface suffer from an ultraviolet (UV) irradiation and orbital atomic oxygen (AO) erosion. These…”
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A Rare Case of Adrenocorticotropic Hormone (ACTH)-independent Macroadrenal Hyperplasia Showing Ectopic Production of ACTH by Iwata, Minoru, Oki, Yutaka, Okazawa, Teruyo, Ishizawa, Shin, Taka, Chihiro, Yamazaki, Katsuya, Tobe, Kazuyuki, Fukuoka, Junya, Sasano, Hironobu, Nishikawa, Tetsuo

“…A 57-year-old Japanese man presented with drug-resistant hypertension without Cushingoid features. Endocrinological tests revealed autonomous secretion of…”
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Secretory units of islets in transplantation index is a useful predictor of insulin requirement in Japanese type 2 diabetic patients by Iwata, Minoru, Matsushita, Yumi, Fukuda, Kazuhito, Wakura, Tatsurou, Okabe, Keisuke, Koshimizu, Yukiko, Fukushima, Yasuo, Kobashi, Chikaaki, Yamazaki, Yu, Honoki, Hisae, Suzuki, Hikari, Kigawa, Mika, Tobe, Kazuyuki

“…Aims/Introduction The objective of the present study was to clarify the validity of β‐cell function‐related parameters for predicting the insulin requirement…”
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Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population by Fukuda, Hisashi, Imamura, Minako, Tanaka, Yasushi, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Maeda, Shiro

“…By an association mapping for the candidate locus in chromosome 21q, rs3746876 within KCNJ15 was shown to be associated with type 2 diabetes in Japanese…”
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