Search Results - "Minniti, Alicia N"

Methionine sulfoxide reductase A expression is regulated by the DAF‐16/FOXO pathway in Caenorhabditis elegans by Minniti, Alicia N., Cataldo, Romina, Trigo, Carla, Vasquez, Luis, Mujica, Patricio, Leighton, Federico, Inestrosa, Nibaldo C., Aldunate, Rebeca

“…Summary The methionine sulfoxide reductase system has been implicated in aging and protection against oxidative stress. This conserved system reverses the…”
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Circadian stress tolerance in adult Caenorhabditis elegans by Simonetta, Sergio H, Romanowski, Andrés, Minniti, Alicia N, Inestrosa, Nibaldo C, Golombek, Diego A

“…Circadian rhythms control several behaviors through neural networks, hormones and gene expression. One of these outputs in invertebrates, vertebrates and…”
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Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease by Morales-Zavala, Francisco, Arriagada, Hector, Hassan, Natalia, Velasco, Carolina, Riveros, Ana, Álvarez, Alejandra R., Minniti, Alicia N., Rojas-Silva, Ximena, Muñoz, Luis L., Vasquez, Rodrigo, Rodriguez, Katherine, Sanchez-Navarro, Macarena, Giralt, Ernest, Araya, Eyleen, Aldunate, Rebeca, Kogan, Marcelo J.

“…The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods…”
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Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification by Minniti, Alicia N, Rebolledo, Daniela L, Grez, Paula M, Fadic, Ricardo, Aldunate, Rebeca, Volitakis, Irene, Cherny, Robert A, Opazo, Carlos, Masters, Colin, Bush, Ashley I, Inestrosa, Nibaldo C

“…Abstract Background The amyloid β-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic…”
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Age-related NMDA signaling alterations in SOD2 deficient mice by Carvajal, Francisco J., Mira, Rodrigo G., Rovegno, Maximiliano, Minniti, Alicia N., Cerpa, Waldo

“…Oxidative stress affects the survival and function of neurons. Hence, they have a complex and highly regulated machinery to handle oxidative changes. The…”
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Surface enhanced fluorescence effect improves the in vivo detection of amyloid aggregates by Cabrera, Pablo, Jara-Guajardo, Pedro, Oyarzún, María Paz, Parra-Muñoz, Nicole, Campos, Aldo, Soler, Mónica, Álvarez, Alejandra, Morales-Zavala, Francisco, Araya, Eyleen, Minniti, Alicia N., Aldunate, Rebeca, Kogan, Marcelo J.

“…The β-amyloid (Aβ) peptide is one of the key etiological agents in Alzheimer's disease (AD). The in vivo detection of Aβ species is challenging in all stages…”
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The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Aβ aggregation and toxicity in vivo by Minniti, Alicia N, Arrazola, Macarena S, Bravo-Zehnder, Marcela, Ramos, Francisca, Inestrosa, Nibaldo C, Aldunate, Rebeca

“…To examine the role of the enzyme methionine sulfoxide reductase A-1 (MSRA-1) in amyloid-β peptide (Aβ)-peptide aggregation and toxicity in vivo, using a…”
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Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis by Minniti, Alicia N., Arriagada, Héctor, Zúñiga, Soledad, Bravo‐Zehnder, Marcela, Alfaro, Iván E., Aldunate, Rebeca

“…The insulin‐IGF‐1/DAF‐2 pathway has a central role in the determination of aging and longevity in Caenorhabditis elegans and other organisms. In this paper, we…”
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Copper reduces Aβ oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis by Rebolledo, Daniela L, Aldunate, Rebeca, Kohn, Rebecca, Neira, Iván, Minniti, Alicia N, Inestrosa, Nibaldo C

“…Alzheimer's disease and inclusion body myositis (IBM) are disorders frequently found in the elderly and characterized by the presence of amyloid-β peptide (Aβ)…”
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Beta-amyloid peptide and synaptic function in Caenorhabditis elegans by Minniti, Alicia N

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Is there a role for copper in neurodegenerative diseases? by Cerpa, Waldo, Varela-Nallar, Lorena, Reyes, Ariel E., Minniti, Alicia N., Inestrosa, Nibaldo C.

“…Copper is an essential metal in living organisms; thus, the maintenance of adequate copper levels is of vital importance and is highly regulated. Dysfunction…”
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Genetic and Molecular Analysis of spe-27, a Gene Required for Spermiogenesis in Caenorhabditis elegans Hermaphrodites by Minniti, A. N, Sadler, C, Ward, S

“…Hermaphrodites with mutations in the spe-27 gene are self-sterile, laying only unfertilized eggs; mutant males are fertile. Hermaphrodites make spermatids that…”
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Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva by Minniti, Alicia N, Labarca, Mariana, Hurtado, Claudia, Brandan, Enrique

“…In Caenorhabditis elegans, the identification of many enzymes involved in the synthesis and modification of glycosaminoglycans (GAGs), essential components of…”
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Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle by Rebolledo, Daniela L., Minniti, Alicia N., Grez, Paula M., Fadic, Ricardo, Kohn, Rebecca, Inestrosa, Nibaldo C.

“…Inclusion body myositis (IBM) is the most common myopathy in people over 50 years of age. It involves an inflammatory process that, paradoxically, does not…”
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spe-12 Encodes a Sperm Cell Surface Protein That Promotes Spermiogenesis in Caenorhabditis elegans by Nance, Jeremy, Minniti, Alicia N, Sadler, Cathryn, Ward, Samuel

“…During spermiogenesis, Caenorhabditis elegans spermatids activate and mature into crawling spermatozoa without synthesizing new proteins. Mutations in the…”
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F1‐01‐03: Beta‐amyloid peptide and synaptic function in Caenorhabditis elegans by Minniti, Alicia N.

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Glutamate receptors may not protect against oxidative stress in C. elegans by Alicia N. Minniti, Eryn Fennelly, Brenna Duffy, Natausha Davis, Elizabeth Chatburn, Nibaldo C. Inestrosa, Rebecca E. Kohn

“…Oxidative stress is considered a significant contributor to cellular damage, which may accumulate and result in cellular and organism senescence and death…”
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Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification by Minniti, Alicia N, Rebolledo, Daniela L, Grez, Paula M, Fadic, Ricardo, Aldunate, Rebeca, Volitakis, Irene, Cherny, Robert A, Opazo, Carlos, Masters, Colin, Bush, Ashley I, Inestrosa, Nibaldo C

“…The amyloid beta-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic aggregates. The…”
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The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin by Varkey, J P, Muhlrad, P J, Minniti, A N, Do, B, Ward, S

“…Six independent mutations in the Caenorhabditis elegans spe-26 gene cause sterility in males and hermaphrodites by disrupting spermatogenesis. Spermatocytes in…”
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The Caenorhabditis elegans spe-6 Gene Is Required for Major Sperm Protein Assembly and Shows Second Site Non-Complementation With an Unlinked Deficiency by Varkey, J. P, Jansma, P. L, Minniti, A. N, Ward, S

“…Caenorhabditis elegans spermatozoa move by crawling. Their motility requires thin cytoskeletal filaments assembled from a unique cytoskeletal protein, the…”
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