Search Results - "Minnie, Simone A"

Autologous Stem Cell Transplantation for Myeloma: Cytoreduction or an Immunotherapy? by Minnie, Simone A, Hill, Geoffrey R

“…The incidence of multiple myeloma (MM), a bone marrow (BM) resident hematological malignancy, is increasing globally. The disease has substantial morbidity and…”
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TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice by Minnie, Simone A, Waltner, Olivia G, Ensbey, Kathleen S, Olver, Stuart D, Collinge, Alika D, Sester, David P, Schmidt, Christine R, Legg, Samuel Rw, Takahashi, Shuichiro, Nemychenkov, Nicole S, Sekiguchi, Tomoko, Driessens, Gregory, Zhang, Ping, Koyama, Motoko, Spencer, Andrew, Holmberg, Leona A, Furlan, Scott N, Varelias, Antiopi, Hill, Geoffrey R

“…Autologous stem cell transplantation (ASCT) with subsequent lenalidomide maintenance is standard consolidation therapy for multiple myeloma, and a subset of…”
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IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling by Wilkinson, Andrew N., Chang, Karshing, Kuns, Rachel D., Henden, Andrea S., Minnie, Simone A., Ensbey, Kathleen S., Clouston, Andrew D., Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Gartlan, Kate H., Hill, Geoffrey R.

“…Graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloSCT) is characterized by interleukin-6 (IL-6) dysregulation. IL-6 can mediate…”
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Oncogenic drivers dictate immune control of acute myeloid leukemia by Austin, Rebecca J., Straube, Jasmin, Halder, Rohit, Janardhanan, Yashaswini, Bruedigam, Claudia, Witkowski, Matthew, Cooper, Leanne, Porter, Amy, Braun, Matthias, Souza-Fonseca-Guimaraes, Fernando, Minnie, Simone A., Cooper, Emily, Jacquelin, Sebastien, Song, Axia, Bald, Tobias, Nakamura, Kyohei, Hill, Geoffrey R., Aifantis, Iannis, Lane, Steven W., Bywater, Megan J.

“…Acute myeloid leukemia (AML) is a genetically heterogeneous, aggressive hematological malignancy induced by distinct oncogenic driver mutations. The effect of…”
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Multiparametric flow cytometry to characterize vaccine-induced polyfunctional T cell responses and T cell/NK cell exhaustion and memory phenotypes in mouse immuno-oncology models by Moi, Davide, Zeng, Bijun, Minnie, Simone A, Bhatt, Rituparna, Wood, Jack, Sester, David P, Mazzieri, Roberta, Dolcetti, Riccardo

“…Suitable methods to assess immunogenicity and therapeutic efficacy of cancer vaccines in preclinical cancer models are critical to overcome current limitations…”
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Immunotherapy of multiple myeloma by Minnie, Simone A, Hill, Geoffrey R

“…Multiple myeloma (MM), a bone marrow-resident hematological malignancy of plasma cells, has remained largely incurable despite dramatic improvements in patient…”
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Peritransplant glucocorticoids redistribute donor T cells to the bone marrow and prevent relapse after haploidentical SCT by Inoue, Takayuki, Koyama, Motoko, Kaida, Katsuji, Ikegame, Kazuhiro, Ensbey, Kathleen S, Samson, Luke, Takahashi, Shuichiro, Zhang, Ping, Minnie, Simone A, Maruyama, Satoshi, Ishii, Shinichi, Daimon, Takashi, Fukuda, Takahiro, Nakamae, Hirohisa, Ara, Takahide, Maruyama, Yumiko, Ishiyama, Ken, Ichinohe, Tatsuo, Atsuta, Yoshiko, Blazar, Bruce R, Furlan, Scott N, Ogawa, Hiroyasu, Hill, Geoffrey R

“…Patients with acute leukemia who are unable to achieve complete remission prior to allogeneic hematopoietic stem cell transplantation (SCT) have dismal…”
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Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD. Reply by Zhang, Ping, Minnie, Simone A, Hill, Geoffrey R

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TIGIT immune checkpoint blockade restores CD8+ T-cell immunity against multiple myeloma by Guillerey, Camille, Harjunpää, Heidi, Carrié, Nadège, Kassem, Sahar, Teo, Tricia, Miles, Kim, Krumeich, Sophie, Weulersse, Marianne, Cuisinier, Marine, Stannard, Kimberley, Yu, Yuan, Minnie, Simone A., Hill, Geoffrey R., Dougall, William C., Avet-Loiseau, Hervé, Teng, Michele W.L., Nakamura, Kyohei, Martinet, Ludovic, Smyth, Mark J.

“…Immune-based therapies hold promise for the treatment of multiple myeloma (MM), but so far, immune checkpoint blockade targeting programmed cell death protein…”
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Myeloma escape after stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade by Minnie, Simone A., Kuns, Rachel D., Gartlan, Kate H., Zhang, Ping, Wilkinson, Andrew N., Samson, Luke, Guillerey, Camille, Engwerda, Christian, MacDonald, Kelli P.A., Smyth, Mark J., Markey, Kate A., Vuckovic, Slavica, Hill, Geoffrey R.

“…Autologous stem cell transplantation (SCT) remains a standard of care for multiple myeloma (MM) patients and prolongs progression-free survival. A small cohort…”
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Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation by Takahashi, Shuichiro, Minnie, Simone A., Ensbey, Kathleen S., Schmidt, Christine R., Sekiguchi, Tomoko, Legg, Samuel R. W., Zhang, Ping, Koyama, Motoko, Olver, Stuart D., Collinge, Alika D., Keshmiri, Sara, Comstock, Melissa L., Varelias, Antiopi, Green, Damian J., Hill, Geoffrey R.

“…•T cells from bone marrow egress to blood during SCM and preferentially home back to marrow after adoptive transfer.•Treg depletion during SCM expands…”
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Bone marrow transplantation generates T cell-dependent control of myeloma in mice by Vuckovic, Slavica, Minnie, Simone A, Smith, David, Gartlan, Kate H, Watkins, Thomas S, Markey, Kate A, Mukhopadhyay, Pamela, Guillerey, Camille, Kuns, Rachel D, Locke, Kelly R, Pritchard, Antonia L, Johansson, Peter A, Varelias, Antiopi, Zhang, Ping, Huntington, Nicholas D, Waddell, Nicola, Chesi, Marta, Miles, John J, Smyth, Mark J, Hill, Geoffrey R

“…Transplantation with autologous hematopoietic progenitors remains an important consolidation treatment for patients with multiple myeloma (MM) and is thought…”
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Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity by Koyama, Motoko, Hippe, Daniel S., Srinivasan, Sujatha, Proll, Sean C., Miltiadous, Oriana, Li, Naisi, Zhang, Ping, Ensbey, Kathleen S., Hoffman, Noah G., Schmidt, Christine R., Yeh, Albert C., Minnie, Simone A., Strenk, Susan M., Fiedler, Tina L., Hattangady, Namita, Kowalsky, Jacob, Grady, Willian M., Degli-Esposti, Mariapia A., Varelias, Antiopi, Clouston, Andrew D., van den Brink, Marcel R.M., Dey, Neelendu, Randolph, Timothy W., Markey, Kate A., Fredricks, David N., Hill, Geoffrey R.

“…Acute graft-versus-host disease (aGVHD) remains a major limitation of allogeneic stem cell transplantation (SCT), and severe intestinal manifestation is the…”
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Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation by Yeh, Albert C, Koyama, Motoko, Waltner, Olivia G, Minnie, Simone A, Boiko, Julie R, Shabaneh, Tamer B, Takahashi, Shuichiro, Zhang, Ping, Ensbey, Kathleen S, Schmidt, Christine R, Legg, Samuel R W, Sekiguchi, Tomoko, Nelson, Ethan, Bhise, Shruti S, Stevens, Andrew R, Goodpaster, Tracy, Chakka, Saranya, Furlan, Scott N, Markey, Kate A, Bleakley, Marie E, Elson, Charles O, Bradley, Philip H, Hill, Geoffrey R

“…Allogeneic T cell expansion is the primary determinant of graft-versus-host disease (GVHD), and current dogma dictates that this is driven by…”
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Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD by Wang, Yewei, Ullah, Md Ashik, Waltner, Olivia G, Bhise, Shruti S, Ensbey, Kathleen S, Schmidt, Christine R, Legg, Samuel Rw, Sekiguchi, Tomoko, Nelson, Ethan L, Kuns, Rachel D, Nemychenkov, Nicole S, Atilla, Erden, Yeh, Albert C, Takahashi, Shuichiro, Boiko, Julie R, Varelias, Antiopi, Blazar, Bruce R, Koyama, Motoko, Minnie, Simone A, Clouston, Andrew D, Furlan, Scott N, Zhang, Ping, Hill, Geoffrey R

“…Calcineurin inhibitors (CNIs) constitute the backbone of modern acute graft-versus-host disease (aGVHD) prophylaxis regimens but have limited efficacy in the…”
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IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation by Zhang, Ping, Fleming, Peter, Andoniou, Christopher E, Waltner, Olivia G, Bhise, Shruti S, Martins, Jose Paulo, McEnroe, Benjamin A, Voigt, Valentina, Daly, Sheridan, Kuns, Rachel D, Ekwe, Adaeze P, Henden, Andrea S, Saldan, Alda, Olver, Stuart, Varelias, Antiopi, Smith, Corey, Schmidt, Christine R, Ensbey, Kathleen S, Legg, Samuel Rw, Sekiguchi, Tomoko, Minnie, Simone A, Gradwell, Mark, Wagenaar, Irma, Clouston, Andrew D, Koyama, Motoko, Furlan, Scott N, Kennedy, Glen A, Ward, E Sally, Degli-Esposti, Mariapia A, Hill, Geoffrey R, Tey, Siok-Keen

“…Endothelial function and integrity are compromised after allogeneic bone marrow transplantation (BMT), but how this affects immune responses broadly remains…”
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Flt-3L Expansion of Recipient CD8α + Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD by Markey, Kate A, Kuns, Rachel D, Browne, Daniel J, Gartlan, Kate H, Robb, Renee J, Martins, J Paulo, Henden, Andrea S, Minnie, Simone A, Cheong, Melody, Koyama, Motoko, Smyth, Mark J, Steptoe, Raymond J, Belz, Gabrielle T, Brocker, Thomas, Degli-Esposti, Mariapia A, Lane, Steven W, Hill, Geoffrey R

“…Allogeneic bone marrow transplantation (BMT) provides curative therapy for leukemia via immunologic graft-versus-leukemia (GVL) effects. In practice, this must…”
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Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity by Minnie, Simone A, Waltner, Olivia G, Ensbey, Kathleen S, Nemychenkov, Nicole S, Schmidt, Christine R, Bhise, Shruti S, Legg, Samuel R W, Campoy, Gabriela, Samson, Luke D, Kuns, Rachel D, Zhou, Ting, Huck, John D, Vuckovic, Slavica, Zamora, Danniel, Yeh, Albert, Spencer, Andrew, Koyama, Motoko, Markey, Kate A, Lane, Steven W, Boeckh, Michael, Ring, Aaron M, Furlan, Scott N, Hill, Geoffrey R

“…Some hematological malignancies such as multiple myeloma are inherently resistant to immune-mediated antitumor responses, the cause of which remains unknown…”
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TIM-3 + CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies by Minnie, Simone A, Waltner, Olivia G, Zhang, Ping, Takahashi, Shuichiro, Nemychenkov, Nicole S, Ensbey, Kathleen S, Schmidt, Christine R, Legg, Samuel R W, Comstock, Melissa, Boiko, Julie R, Nelson, Ethan, Bhise, Shruti S, Wilkens, Alec B, Koyama, Motoko, Dhodapkar, Madhav V, Chesi, Marta, Riddell, Stanley R, Green, Damian J, Spencer, Andrew, Furlan, Scott N, Hill, Geoffrey R

“…Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we identify a CD8 T cell subset in the bone marrow tumor microenvironment…”
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Immunotherapy of multiple myeloma by Minnie, Simone A, Hill, Geoffrey R

“…Multiple myeloma (MM), a bone marrow-resident hematological malignancy of plasma cells, has remained largely incurable despite dramatic improvements in patient…”
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