Search Results - "Minnick, D T"

Development of a high throughput in vitro toxicity screen predictive of high acute in vivo toxic potential by Evans, S.M, Casartelli, A, Herreros, E, Minnick, D.T, Day, C, George, E, Westmoreland, C

“…At an early stage of drug discovery high throughput screens are an invaluable tool to de-select compounds with undesirable properties. A high throughout in…”
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DNA Replication Fidelity with 8-Oxodeoxyguanosine Triphosphate by Pavlov, Youri I, Minnick, Dana T, Izuta, Shunji, Kunkel, Thomas A

“…Oxidative metabolism is known to generate mutagenic compounds within cells, among which is 8-oxodeoxyguanosine. Here the mutagenic potential of the…”
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Specificity of bischloroethylnitrosourea-induced mutation in a Chinese hamster ovary cell line transformed to express human O6-alkylguanine-DNA alkyltransferase by MINNICK, D. T, GERSON, S. L, DUMENCO, L. L, VEIGL, M. L, SEDWICK, W. D

“…The human O6-alkylguanine-DNA alkyltransferase complementary DNA was transfected into the alkyltransferase-deficient Chinese hamster ovary cell line, D422, in…”
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DNA synthesis errors, mutators and cancer by Minnick, D T, Kunkel, T A

“…To quote Drake et al (1983), "The list of mutagenic mechanisms is long, and it is far more difficult to write the encyclopedia of all possible errors than the…”
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Side Chains That Influence Fidelity at the Polymerase Active Site of Escherichia coli DNA Polymerase I (Klenow Fragment) by Minnick, D T, Bebenek, K, Osheroff, W P, Turner, Jr, R M, Astatke, M, Liu, L, Kunkel, T A, Joyce, C M

“…To investigate the interactions that determine DNA polymerase accuracy, we have measured the fidelity of 26 mutants with amino acid substitutions in the…”
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Discrimination against Purine-Pyrimidine Mispairs in the Polymerase Active Site of DNA Polymerase I: A Structural Explanation by Minnick, Dana T., Liu, Lixing, Nigel D. F. Grindley, Kunkel, Thomas A., Joyce, Catherine M.

“…We previously identified five derivatives of Klenow fragment DNA polymerase that have lower fidelity because of amino acid substitutions in the polymerase…”
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A Thumb Subdomain Mutant of the Large Fragment of Escherichia coli DNA Polymerase I with Reduced DNA Binding Affinity, Processivity, and Frameshift Fidelity by Minnick, D T, Astatke, M, Joyce, C M, Kunkel, T A

“…In Klenow fragment DNA polymerase, a flexible 50-amino acid subdomain at the tip of the thumb which includes two α helices has been suggested to interact with…”
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The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids by Briscoe, Celia P, Tadayyon, Mohammad, Andrews, John L, Benson, William G, Chambers, Jon K, Eilert, Michelle M, Ellis, Catherine, Elshourbagy, Nabil A, Goetz, Aaron S, Minnick, Dana T, Murdock, Paul R, Sauls, Jr, Howard R, Shabon, Usman, Spinage, Lisa D, Strum, Jay C, Szekeres, Philip G, Tan, Kong B, Way, James M, Ignar, Diane M, Wilson, Shelagh, Muir, Alison I

“…GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed…”
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Role of the "Helix Clamp" in HIV-1 Reverse Transcriptase Catalytic Cycling as Revealed by Alanine-scanning Mutagenesis (∗) by Beard, William A., Minnick, Dana T., Wade, Cheryl L., Prasad, Rajendra, Won, Ran L., Kumar, Amalendra, Kunkel, Thomas A., Wilson, Samuel H.

“…Residues 259-284 of HIV-1 reverse transcriptase exhibit sequence homology with other nucleic acid polymerases and have been termed the “helix clamp” (Hermann,…”
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The fidelity of the human leading and lagging strand DNA replication apparatus with 8-oxodeoxyguanosine triphosphate by Minnick, Dana T., Pavlov, Youri I., Kunkel, Thomas A.

“…A product of oxidatlve metabolism, 8-oxodeoxyguanosine triphosphate (8-O-dGTP), readily pairs with adenlne during DNA replication, ultimately causing A.T→C.G…”
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Sequencing of double-stranded polymerase chain reaction products for mutation analysis by Anderson, R D, Bao, C Y, Minnick, D T, Baxter, J, Veigl, M L, Sedwick, W D

“…This report describes a reproducible, straightforward approach to sequencing double-stranded DNA products from the polymerase chain reaction (PCR) for analysis…”
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Mutational specificity of 1,3-bis-(2-chloroethyl)-1-nitrosourea in a Chinese hamster ovary cell line by Minnick, D T, Veigl, M L, Sedwick, W D

“…The mutational specificity of the alkylating agent 1-3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) was analyzed at the endogenous hemizygous adenine…”
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Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments by Lenhard, James M., Croom, Dallas K., Minnick, Dana T.

“…Dipeptidyl peptidase-IV (DPP-IV) regulates metabolism by degrading incretins involved in nutritional regulation. Metformin and pioglitazone improve insulin…”
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Mutational specificity of 1,3-bis-(2-chloroethyl)-1-nitrosourea in a Chinese hamster ovary cell line by MINNICK, D. T, VEIGL, M. L, DAVID SEDWICK, W

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