Search Results - "Minnella, Angela M"

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP by Shen, Yiguo, Kapfhamer, David, Minnella, Angela M., Kim, Ji-Eun, Won, Seok Joon, Chen, Yanting, Huang, Yong, Low, Ley Hian, Massa, Stephen M., Swanson, Raymond A.

“…The innate inflammatory response contributes to secondary injury in brain trauma and other disorders. Metabolic factors such as caloric restriction, ketogenic…”
Get full text

Cofilin-actin rod formation in neuronal processes after brain ischemia by Won, Seok Joon, Minnella, Angela M, Wu, Long, Eun, Claire H, Rome, Eric, Herson, Paco S, Shaw, Alisa E, Bamburg, James R, Swanson, Raymond A

“…Functional impairment after brain ischemia results in part from loss of neuronal spines and dendrites, independent of neuronal death. Cofilin-actin rods are…”
Get full text

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase by Lam, Tina I., Brennan-Minnella, Angela M., Won, Seok Joon, Shen, Yiguo, Hefner, Colleen, Shi, Yejie, Sun, Dandan, Swanson, Raymond A.

“…Sustained activation of N-methyl-d-aspartate (NMDA) -type glutamate receptors leads to excitotoxic neuronal death in stroke, brain trauma, and…”
Get full text

Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage by Cleaver, James E., Brennan-Minnella, Angela M., Swanson, Raymond A., Fong, Ka-wing, Chen, Junjie, Chou, Kai-ming, Chen, Yih-wen, Revet, Ingrid, Bezrookove, Vladimir

“…Significance Mitochondria are often considered a source of reactive oxygen species (ROS) that cause damage to cellular components including nuclear DNA. This…”
Get full text

NR2B Phosphorylation at Tyrosine 1472 Contributes to Brain Injury in a Rodent Model of Neonatal Hypoxia-Ischemia by Knox, Renatta, Brennan-Minnella, Angela M, Lu, Fuxin, Yang, Diana, Nakazawa, Takanobu, Yamamoto, Tadashi, Swanson, Raymond A, Ferriero, Donna M, Jiang, Xiangning

“…BACKGROUND AND PURPOSE—The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y)…”
Get full text

Sources and consequences of oxidative damage from mitochondria and neurotransmitter signaling by Brennan-Minnella, Angela M., Arron, Sarah T., Chou, Kai-ming, Cunningham, Eric, Cleaver, James E.

“…Cancer and neurodegeneration represent the extreme responses of growing and terminally differentiated cells to cellular and genomic damage. The damage…”
Get full text

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration by Ko, Hyo Rim, Kwon, Il-Sun, Hwang, Inwoo, Jin, Eun-Ju, Shin, Joo-Ho, Brennan-Minnella, Angela M, Swanson, Raymond, Cho, Sung-Woo, Lee, Kyung-Hoon, Ahn, Jee-Yin

“…Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered…”
Get full text

NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke by Brennan-Minnella, Angela M, Won, Seok Joon, Swanson, Raymond A

“…Neuronal superoxide production contributes to cell death in both glutamate excitotoxicity and brain ischemia (stroke). NADPH oxidase-2 (NOX2) is the major…”
Get more information

Tat-NR2B9c Prevents Excitotoxic Neuronal Superoxide Production by Chen, Yanting, Brennan-Minnella, Angela M, Sheth, Sunil, El-Benna, Jamel, Swanson, Raymond A

“…The Tat-NR2B9c peptide has shown clinical efficacy as a neuroprotective agent in acute stroke. Tat-NR2B9c is designed to prevent nitric oxide (NO) production…”
Get full text

Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling by Minnella, Angela M., Zhao, Jerry X., Jiang, Xiangning, Jakobsen, Emil, Lu, Fuxin, Wu, Long, El-Benna, Jamel, Gray, John A., Swanson, Raymond A.

“…NMDA-type glutamate receptors (NMDAR) trigger superoxide production by neuronal NADPH oxidase-2 (NOX2), which if sustained leads to cell death. This process…”
Get full text

Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid by Reyes, Reno C., Cittolin-Santos, Giordano Fabricio, Kim, Ji-Eun, Won, Seok Joon, Brennan-Minnella, Angela M., Katz, Maya, Glass, Graham A., Swanson, Raymond A.

“…N -acetyl cysteine (NAC) supports the synthesis of glutathione (GSH), an essential substrate for fast, enzymatically catalyzed oxidant scavenging and protein…”
Get full text

Erratum to: Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid by Reyes, Reno C., Cittolin-Santos, Giordano Fabricio, Kim, Ji-Eun, Won, Seok Joon, Brennan-Minnella, Angela M., Katz, Maya, Glass, Graham A., Swanson, Raymond A.

“…Issue Title: Immunotherapy of Neurolgical Diseases…”
Get full text

Abstract W MP78: Small Changes in Intracellular pH Block Ischemic and Excitotoxic Cell Death by Suppressing Neuronal Superoxide Production by Won, Seok Joon, Lam, Tina, Brennan-Minnella, Angela M, Shi, Yejie, Sun, Dandan, Swanson, Raymond A

“…Abstract only Tissue acidosis has long been recognized as a crucial variable affecting outcome after brain ischemia, with mild acidosis (pH 7.0 - 6.6)…”
Get full text

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase by Lam, Tina I., Brennan-Minnella, Angela M., Won, Seok Joon, Shen, Yiguo, Hefner, Colleen, Shi, Yejie, Sun, Dandan, Swanson, Raymond A.

Get full text