Search Results - "Mink, Daniel"

Production of the sesquiterpenoid (+)-nootkatone by metabolic engineering of Pichia pastoris by Wriessnegger, Tamara, Augustin, Peter, Engleder, Matthias, Leitner, Erich, Müller, Monika, Kaluzna, Iwona, Schürmann, Martin, Mink, Daniel, Zellnig, Günther, Schwab, Helmut, Pichler, Harald

“…The sesquiterpenoid (+)-nootkatone is a highly demanded and highly valued aroma compound naturally found in grapefruit, pummelo or Nootka cypress tree…”
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Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio‐ and Stereoselective Hydration of Oleic Acid Derivatives by Engleder, Matthias, Strohmeier, Gernot A., Weber, Hansjörg, Steinkellner, Georg, Leitner, Erich, Müller, Monika, Mink, Daniel, Schürmann, Martin, Gruber, Karl, Pichler, Harald

“…The addition of water to non‐activated carbon–carbon double bonds catalyzed by fatty acid hydratases (FAHYs) allows for highly regio‐ and stereoselective…”
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Dispelling the Myths: Biocatalysis in Industrial Synthesis by Schoemaker, Hans E., Mink, Daniel, Wubbolts, Marcel G.

“…Biocatalysis has emerged as an important tool in the industrial synthesis of bulk chemicals, pharmaceutical and agrochemical intermediates, active…”
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Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia meningoseptica by Engleder, Matthias, Pavkov-Keller, Tea, Emmerstorfer, Anita, Hromic, Altijana, Schrempf, Sabine, Steinkellner, Georg, Wriessnegger, Tamara, Leitner, Erich, Strohmeier, Gernot A., Kaluzna, Iwona, Mink, Daniel, Schürmann, Martin, Wallner, Silvia, Macheroux, Peter, Gruber, Karl, Pichler, Harald

“…Hydratases provide access to secondary and tertiary alcohols by regio‐ and/or stereospecifically adding water to carbon‐carbon double bonds. Thereby, hydroxy…”
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A Biocatalytic Henry Reaction-The Hydroxynitrile Lyase from Hevea brasiliensis Also Catalyzes Nitroaldol Reactions by Purkarthofer, Thomas, Gruber, Karl, Gruber-Khadjawi, Mandana, Waich, Kerstin, Skranc, Wolfgang, Mink, Daniel, Griengl, Herfried

“…Novel enzyme activity: Biocatalytic Henry reactions with nitromethane and nitroethane yielded the corresponding nitroalcohols with good enantio‐ and…”
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Exploring Castellaniella defragrans Linalool (De)hydratase-Isomerase for Enzymatic Hydration of Alkenes by Engleder, Matthias, Müller, Monika, Kaluzna, Iwona, Mink, Daniel, Schürmann, Martin, Leitner, Erich, Pichler, Harald, Emmerstorfer-Augustin, Anita

“…Acyclic monoterpenes constitute a large and highly abundant class of secondary plant metabolites and are, therefore, attractive low-cost raw materials for the…”
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Recombinant expression, purification and biochemical characterization of kievitone hydratase from Nectria haematococca by Engleder, Matthias, Horvat, Melissa, Emmerstorfer-Augustin, Anita, Wriessnegger, Tamara, Gabriel, Stefanie, Strohmeier, Gernot, Weber, Hansjörg, Müller, Monika, Kaluzna, Iwona, Mink, Daniel, Schürmann, Martin, Pichler, Harald

“…Kievitone hydratase catalyzes the addition of water to the double bond of the prenyl moiety of plant isoflavonoid kievitone and, thereby, forms the tertiary…”
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The crystal structure of D-threonine aldolase from Alcaligenes xylosoxidans provides insight into a metal ion assisted PLP-dependent mechanism by Uhl, Michael K, Oberdorfer, Gustav, Steinkellner, Georg, Riegler-Berket, Lina, Mink, Daniel, van Assema, Friso, Schürmann, Martin, Gruber, Karl

“…Threonine aldolases catalyze the pyridoxal phosphate (PLP) dependent cleavage of threonine into glycine and acetaldehyde and play a major role in the…”
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Threonine aldolases—an emerging tool for organic synthesis by Steinreiber, Johannes, Fesko, Kateryna, Reisinger, Christoph, Schürmann, Martin, van Assema, Friso, Wolberg, Michael, Mink, Daniel, Griengl, Herfried

“…In a systematic study, 21 ring-substituted benzaldehydes were reacted with glycine under catalysis with a l-threonine aldolase ( lTA) from Pseudomonas putida…”
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Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase by Jennewein, Stefan, Schürmann, Martin, Wolberg, Michael, Hilker, Iris, Luiten, Ruud, Wubbolts, Marcel, Mink, Daniel

“…Aldolases are emerging as powerful and cost efficient tools for the industrial synthesis of chiral molecules. They catalyze enantioselective carbon‐carbon bond…”
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Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD(P)(+) Regeneration in Biocatalytic Oxidations by Petschacher, Barbara, Staunig, Nicole, Müller, Monika, Schürmann, Martin, Mink, Daniel, De Wildeman, Stefaan, Gruber, Karl, Glieder, Anton

“…Soluble water-forming NAD(P)H oxidases constitute a promising NAD(P)(+) regeneration method as they only need oxygen as cosubstrate and produce water as sole…”
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Overcoming Thermodynamic and Kinetic Limitations of Aldolase-Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations by Steinreiber, Johannes, Schürmann, Martin, Wolberg, Michael, van Assema, Friso, Reisinger, Christoph, Fesko, Kateryna, Mink, Daniel, Griengl, Herfried

“…Dynamic and successful: The asymmetric synthesis of 2‐amino‐1‐phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes…”
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Natural products analogs as scaffolds for supramolecular and combinatorial chemistry by Mink, Daniel, Mecozzi, Sandro, Rebek, Julius

“…A new class of analogs of natural products useful for supramolecular and combinatorial chemistry is presented. Starting from the structure of natural…”
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Lysosomally cleavable peptide-containing polymersomes modified with anti-EGFR antibody for systemic cancer chemotherapy by Lee, Jung S, Groothuis, Tom, Cusan, Claudia, Mink, Daniel, Feijen, Jan

“…Abstract Polymersomes (Ps) based on a biodegradable and biocompatible block copolymer of methoxy poly(ethylene glycol) (mPEG) and poly( d , l -lactide) (PDLLA)…”
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Process development for oxidations of hydrophobic compounds applying cytochrome P450 monooxygenases in-vitro by Brummund, Jan, Müller, Monika, Schmitges, Thomas, Kaluzna, Iwona, Mink, Daniel, Hilterhaus, Lutz, Liese, Andreas

“…•Cofactor regeneration system using glucose dehydrogenase successfully implemented.•Addition of low surfactant and co-solvent amounts enhanced reaction…”
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Enabling Selective and Sustainable P450 Oxygenation Technology. Production of 4‑Hydroxy-α-isophorone on Kilogram Scale by Kaluzna, Iwona, Schmitges, Thomas, Straatman, Harrie, van Tegelen, Dennis, Müller, Monika, Schürmann, Martin, Mink, Daniel

“…The development of P450 platform technology has enabled the sustainable production of an oxygenated intermediate, 4-hydroxy-α-isophorone, on kilogram scale…”
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A future perspective on the role of industrial biotechnology for chemicals production by Woodley, John M., Breuer, Michael, Mink, Daniel

“…•State-of-the-art in industrial biotechnology for chemicals production.•Drivers for the implementation of industrial biotechnology.•Key challenges for further…”
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Enhancing cytochrome P450-mediated conversions in P. pastoris through RAD52 over-expression and optimizing the cultivation conditions by Wriessnegger, Tamara, Moser, Sandra, Emmerstorfer-Augustin, Anita, Leitner, Erich, Müller, Monika, Kaluzna, Iwona, Schürmann, Martin, Mink, Daniel, Pichler, Harald

“…[Display omitted] •Transcriptome response to plant terpenoid biosynthesis evaluated in Pichia pastoris.•RAD52 upregulation in minimal media, pH 8, boosted…”
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Semi-rational engineering of cytochrome CYP153A from Marinobacter aquaeolei for improved ω-hydroxylation activity towards oleic acid by Duan, Yan, Ba, Lina, Gao, Jianwei, Gao, Xianxing, Zhu, Dunming, de Jong, René M., Mink, Daniel, Kaluzna, Iwona, Lin, Zhanglin

“…ω-Hydroxy oleic acid is an important intermediate for the synthesis of certain polyesters and polyamides. In this study, a functional CYP153A/putidaredoxin…”
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Semi-rational engineering of cytochrome CYP153A from Marinobacter aquaeolei for improved [omega]-hydroxylation activity towards oleic acid by Duan, Yan, Ba, Lina, Gao, Jianwei, Gao, Xianxing, Zhu, Dunming, de Jong, Rene M, Mink, Daniel, Kaluzna, Iwona, Lin, Zhanglin

“…[omega]-Hydroxy oleic acid is an important intermediate for the synthesis of certain polyesters and polyamides. In this study, a functional…”
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